Using novel hydrophobic deep eutectic solvents to improve a sustainable carotenoid extraction from orange peels

Viñas-Ospino, Adriana; Panić, Manuela; Redovniković, Ivana Radojčić; Blesa, Jesús; Esteve, María J.

doi:10.1016/j.fbio.2023.102570

Cited by 31 publications

(10 citation statements)

References 41 publications

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“…Despite the limited number of studies available in the literature, the COSMO model has demonstrated promising results in exploring the screening of tailor-made solvents for carotenoid recovery (Rajabi et al 2017;Mussagy et al 2022a;Xu et al 2022;Viñas-Ospino et al 2023b). Predictive tools such as the COSMO model are highly relevant in contributing to the viability of separation processes for valuable products like carotenoids obtained from microbial sources.…”

Section: In Silico Tools For Tailoring Solventsmentioning

confidence: 99%

Tailor-made solvents for microbial carotenoids recovery

Mussagy,

Hucke,

Ramos

et al. 2024

Appl Microbiol Biotechnol

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In recent years, microbial carotenoids have emerged as a promising alternative for the pharmaceutical and food industries, particularly in promoting human health due to their potent antioxidant and antimicrobial properties. Microbial carotenoids, particularly those produced by yeast, bacteria, and microalgae, are synthesized intracellularly, requiring the use of solvents for their effective extraction and recovery. The conventional use of toxic volatile organic solvents (VOCs) like hexane, petroleum ether, and dimethyl sulfoxide in the extraction of microbial carotenoids has been common. However, ongoing research is introducing innovative, non-toxic, environmentally friendly tailor-made solvents, such as ionic liquids (IL) and deep eutectic solvents (DES), indicating a new era of cleaner and biocompatible technologies. This review aims to highlight recent advancements in utilizing IL and DES for obtaining carotenoids from microorganisms. Additionally, we explore the utilization of in silico tools designed to determine the solubilities of microbial carotenoids in tailor-made DES and ILs. This presents a promising alternative for the scientific community, potentially reducing the need for extensive experimental screening of solvents for the recovery of microbial carotenoids in the separation processing. According to our expert perspective, both IL and DES exhibit a plethora of exceptional attributes for the recovery of microbial carotenoids. Nevertheless, the current employment of these solvents for recovery of carotenoids is restricted to scientific exploration, as their feasibility for practical application in industrial settings has yet to be conclusively demonstrated. Key points • ILs and DES share many tailoring properties for the recovery of microbial carotenoids • The use of ILs and DES for microbial carotenoid extraction remains driven by scientific curiosity. • The economic feasibility of ILs and DES is yet to be demonstrated in industrial applications.

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Section: In Silico Tools For Tailoring Solventsmentioning

confidence: 99%

Tailor-made solvents for microbial carotenoids recovery

Mussagy,

Hucke,

Ramos

et al. 2024

Appl Microbiol Biotechnol

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“…, phenolic compounds, carotenoids) from various plant materials, e.g. , pumpkin, 33 ginseng, 48 wine lees, 49 mango peels, 50 apple pomace, 51 mangoes, 52 Cosmos sulphureus , 53 orange peels, 54 Cinnamomum cassia bark 55 and blueberry leaves, 56 whereas the number of studies that use UAE coupled to DESs for such purposes has been steadily increasing. An overview of representative studies is presented in Table 1.…”

Section: Innovative Extraction Techniques Coupled To Dessmentioning

confidence: 99%

Coupling deep eutectic solvents with innovative extraction techniques towards plant derived bioactive compositions

Kyriakoudi,

Radojčić Redovniković,

Vidović

et al. 2024

RSC Sustain.

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“…However, there is a growing trend to modify DESs and their properties. Many researchers focus on hydrophobic DESs, which have a great potential for the extraction of less polar compounds, e.g., carotenoids, sulforaphane, and ginkgolic acids. ,, The other tendency is to prepare ternary DESs and NADESs, composed usually of choline chloride, diol or polyalcohol, and acid, e.g., choline chloride/lactic acid/ethylene glycol or choline chloride/butanediol/citric acid, where the acidity can be tuned by using different amounts of acids. , In addition, the development of switchable systems is receiving more attention. With the use of such a system, an efficient and selective separation of compounds with different polarities is possible.…”

Section: Future Prospectsmentioning

confidence: 99%

“…237−239 Carotenoids are chemicals that are commonly present in edible plants, but due to their hydrophobic nature, the recent literature focuses on applying hydrophobic DESs in their extraction. 240 Table 7 presents a brief review on other chemicals extracted using DESs. such as ethanol, methanol, and acetone 245 and extraction with the aid of stirring and heating, commonly used together with the assistance of ultrasound or microwaves.…”

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

“…Other interesting natural chemicals are alkaloids with potential anti-inflammatory bioactivities. This group of compounds has many possible applications, such as the improvement of immunological defense and the treatment of cardiovascular and liver diseases. − Carotenoids are chemicals that are commonly present in edible plants, but due to their hydrophobic nature, the recent literature focuses on applying hydrophobic DESs in their extraction Table presents a brief review on other chemicals extracted using DESs. ,,− …”

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

See 1 more Smart Citation

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Wawoczny

Gillner

2023

J. Agric. Food Chem.

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There is growing interest in reducing the number of synthetic products or additives and replacing them with natural ones. The pharmaceutical, cosmetic, and food industries are especially focused on natural and bioactive chemicals isolated from plants or microorganisms. The main challenge here is to develop efficient and ecological methods for their isolation. According to the strategies and rules of sustainable development and green chemistry, green solvents and environmentally friendly technologies must be used. The application of deep eutectic solvents as efficient and biodegradable solvents seems to be a promising alternative to traditional methods. They are classified as being green and ecological but, most importantly, very efficient extraction media compared to organic solvents. The aim of this review is to present the recent findings on green extraction, as well as the biological activities and the possible applications of natural plant ingredients, namely, phenolics, flavonoids, terpenes, saponins, and some others. This paper thoroughly reviews modern, ecological, and efficient extraction methods with the use of deep eutectic solvents (DESs). The newest findings, as well as the factors influencing the efficiency of extraction, such as water content, and hydrogen bond donor and acceptor types, as well as the extraction systems, are also discussed. New solutions to the major problem of separating DESs from the extract and for solvent recycling are also presented.

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Using novel hydrophobic deep eutectic solvents to improve a sustainable carotenoid extraction from orange peels

Cited by 31 publications

References 41 publications

Tailor-made solvents for microbial carotenoids recovery

Tailor-made solvents for microbial carotenoids recovery

Coupling deep eutectic solvents with innovative extraction techniques towards plant derived bioactive compositions

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

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