Using phonocardiography to investigate maternal cardiac reserve function in gestational hypertension and pre‐eclampsia

Shao, Yong; Zhang, Yinghong; Liu, Ou Mamie

doi:10.1111/j.1447-0756.2012.01897.x

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…A previous study showed that the D/S is a noninvasive indicator for evaluating cardiac reserve. Application of the D/S to cardiac function assessment in various populations, such as preterm infants, 13 neonates, 14 healthy young people 15 and pregnant women, 16 has been studied. Nevertheless, measurement of the D/S among different CHF phenotypes has not been investigated, and its associations with echocardiography measurements has received little attention and has not previously been revealed.…”

Section: Discussionmentioning

confidence: 99%

Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

Liu¹,

Liao²,

Wang³

et al. 2021

IJGM

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Background This study aimed to investigate the correlation between the ratio of diastolic to systolic durations (D/S) and echocardiographic parameters of patients with chronic heart failure (CHF) and evaluate whether the D/S can be used as a supplementary biomarker for the classification of heart failure (HF) phenotypes. Methods In total, 122 CHF patients with a left ventricular ejection fraction (LVEF) <40%, 40%≤LVEF<50%, or ≥50% were categorized as having HF with a reduced ejection fraction (HFrEF) (N=32), HF with a mid-range ejection fraction (HFmrEF) (N=21) or HF with a preserved ejection fraction (HFpEF) (N=69), respectively. All patients underwent echocardiography for assessment of nineteen structural and functional echocardiographic parameters and digital phonocardiography for the measurement of D/S. Spearman correlation was used to analyse the associations between the D/S and echocardiographic parameters. Multivariate logistic regression analysis was performed to examine the associations between the D/S and HF phenotypes, and receiver operating characteristic (ROC) curve analysis was employed to evaluate the predictive value of the D/S in the classification of HF phenotypes. Results The D/S values of patients with HFrEF, HFmrEF and HFpEF were 1.32±0.06, 1.44±0.11 and 1.54±0.08, respectively, which were significantly different (All P<0.05). A close correlation between the D/S and LVEF was found (r=0.777, P<0.001). The multivariate analysis indicated that the D/S was an independent risk factor for CHF phenotypes (OR=4.927, 95% CI 2.532–9.587; P<0.001). The area under the ROC curve for distinguishing between HFmrEF and HFpEF using the D/S was 0.764 (95% CI 0.707–0.845; P < 0.001) and that for distinguishing between HFmrEF and HFrEF using the D/S was 0.821 (95% CI 0.755–0.882; P < 0.001). Conclusion The D/S was significantly associated with LVEF, and as LVEF decreased, the D/S tended to decrease, which could also serve as a noninvasive supplementary indicator for detecting systolic and diastolic dysfunction.

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Section: Discussionmentioning

confidence: 99%

Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

Liu¹,

Liao²,

Wang³

et al. 2021

IJGM

View full text Add to dashboard Cite

show abstract

“…Our team also studied the application of D/S ratio indicator in other fields, such as in preterm infants [6], in neonates [7], in healthy children aged 1 -18 years [5,8,9], in children with atrial septal defect [10], in coal miners [11], in pregnant women [12][13][14], and in middle-aged and elderly person [15]. The corresponding data of D/S ratio were obtained, which have been used to evaluate cardiac functional status in healthy persons or patients.…”

Section: Applications Of D/s Ratio Indicatormentioning

confidence: 99%

Multi-center pragmatic studies evaluating the time indicator of cardiac perfusion reserve

Xiong¹,

Xiao²,

Zhou³

et al. 2013

JBiSE

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Background: Since the greater part of coronary blood flow takes place during the diastolic phase of each cardiac cycle, a time indicator of myocardial perfusion reserve, the ratio of diastolic to systolic duration (D/S ratio), was presented. The objective of this study was to evaluate the accuracy and precision, the biological implication, and the applications of D/S ratio. Methods: Multi-center pragmatic studies evaluating the time indicator of cardiac perfusion reserve were performed. Related experiments, clinical trials, and surveys were conducted at 5 centers. Results: The results showed that the measurement of D/S ratio is both accurate and precise; the mean values of D/S of all of the 3 species studied (human, rabbit, and rat) were greater than 1. These application studies on D/S ratio showed that a close negative correlation existed between D/S ratio and New York Heart Association Functional Classification (NYHA FC) (r = –0.659, p < 0.01); normal persons were mostly distributed at NYHA FC I and at high value of D/S ratio; the patients with cardiovascular disease were mostly at low value of D/S ratio; the difference of D/S between pregnant women with pre-eclampsia and either normal pregnant women or non-pregnant women were significant (p < 0.05); athletes had higher D/S ratio than non-athletes (2.04 ± 0.33 vs 1.82 ± 0.27, p < 0.01). Conclusions: D/S ratio has important biological implication, which is a safe, easy, reliable, and effective indicator, can be used to evaluate fitness levels, served as a pathophysiological marker for screening of cardiovascular disease (CVD), for predicting risk of cardiac events, and for evaluating the severity and prognosis of CVD.

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Evaluation of Cardiac Reserve Function in Gestational Hypertension

Weng¹

2015

J Neonatal Biol

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Materials and Methods Hypertensive disorders complicating pregnancy(HDCP)is a pregnancy-specific disease. It often occurs after 20 weeks and the incidence was 9.4% in our country while 7%-12% [1] in the foreign reports. Hypertensive disorders in pregnancy is a great harm for maternals which can seriously damage the heart, brain, kidney and other organs of pregnant woman [2,3] and the incidence of premature children, fetal growth restriction, fetal distress are significantly higher. So it is the main cause of maternal and perinatal morbidity and mortality, ranking in the first 5 reasons of maternal death [4,5]. From the study of cardiac reserve function, we can reduce maternal mortality and improve the quality of perinatal care. General information This is a prospective study. Under the inclusion criteria, 112 pregnant women with gestational hypertension who do perinatal care in Department of Women's Health Care Division of Third Affiliated Hospital of Zhengzhou University from January 2009 to December 2012 were selected at random. They aged from 22 to 42 years whose mean age is 28.7 ± 3.8 years old and the gestational age ranged from 20 +1 to 39 weeks. On the other hand, we selected 224 normal pregnant women in the corresponding period who aged from 20 to 39 years (the mean age is 27.3 ± 3.8 years old) and the gestational age from 18 +2 to 40 weeks. All the pregnant women selected in the study had no other pregnancy complications. This study was approved by the Ethic Committee of Third Affiliated Hospital of Zhengzhou University, and informed consent was obtained from all participants. Criteria The diagnostic criteria of hypertensive disorders in pregnancy refer to the sixth edition of Obstetrics and Gynecology in 2004. Gestational hypertension refers to blood pressure elevated during pregnancy for the first time (blood pressure ≥ 140/90 mmHg, measuring 2 times interval of at least 4 hours) and the urine protein was negative, no other pregnancy-related complications (such as intrahepatic, cholestasis of pregnancy, gestational diabetes); no previous significant medical history (heart problems, hypertension or diabetes), and not taking any medication, known to affect heart function. Normal pregnant women refers to at least two blood pressure readings < 130/80 mmHg, no pregnancy-related complications, no significant medical history and not taking any medication known to affect heart function. Methods Collect the heart sound signals of the pregnant women with Cardiac Contractility Monitor (CCM, Bojing Medical Informatics Institute of Chongqing University model, patent number 01256971.2). This was the same device and specificity as used in the study by Xie et al and Shao et al. Then measure the amplitude and time of ingredients about heart sound and calculate S1/S2,D/S and HR. Statistical analysis Using SPSS 17.0 statistical software for statistical analysis. The index can be represented by x s ± , using group design. Statistical comparisons between groups were performed with a t-test, α=0.05 is the standard of the te...

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Using phonocardiography to investigate maternal cardiac reserve function in gestational hypertension and pre‐eclampsia

Abstract: Our findings indicate that cardiac reserve function declines with the increasing severity of hypertension during pregnancy. Phonocardiography is a useful, convenient and clinically worthwhile technique to monitor cardiac reserve function parameters of pregnant women with pre-eclampsia.

Cited by 3 publications

References 22 publications

Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

Study of the Correlation Between the Ratio of Diastolic to Systolic Durations and Echocardiography Measurements and Its Application to the Classification of Heart Failure Phenotypes

Multi-center pragmatic studies evaluating the time indicator of cardiac perfusion reserve

Evaluation of Cardiac Reserve Function in Gestational Hypertension

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