Using quantitative imaging to determine the correlation between hypothalamic inflammation and anxiety and depression in young patients with obesity

Dong, Guanzhong; Yang, Haojun; Jiao, Yuwen; Zhang, Qiaoyang; Ma, Yi; Zhu, Shumin; Zhang, Li-Hao; Zhang, Min; Yao, Tian; Cao, Yin; Tang, Liming

doi:10.21037/apm-21-1480

Cited by 4 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interaction between thyroid hormones and glial cells is also relevant to the adult brain (27); it may be a novel target for improving cognitive function in young first-episode drug-naive (FEDN) depressed patients (28). It may be an intervention for disease onset and progression (29,30). While the increased incidence of thyroid disease and MDD in younger people makes it necessary for us to explore the incidence in younger populations.…”

Section: Introductionmentioning

confidence: 99%

Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors

Zhunian

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

ObjectiveThe incidence of thyroid dysfunction (TD) and major depressive disorder (MDD) is increasing year by year in the general population. However, the prevalence and correlates of TD in first-episode drug-naive (FEDN) MDD patients have not been explored. This study sought to fill this gap and examine the association between TD and MDD.MethodsWe recruited 1,289 FEDN MDD patients aged 18 ~ 45 years. A total of 1,289 FEDN MDD outpatients were recruited. Demographical and suicide data were collected for each patient, and lipid profiles, thyroid function, and fasting blood glucose (FBG) levels were measured. The Hamilton Depression Scale 17 (HAMD-17) was assessed for depression.ResultsThe prevalence of TD in young FEDN MDD patients was 64.86%. Compared with those without TD, patients with TD had longer duration of illness, greater HAMD score, higher BMI, TG, TC, and LDL-C levels, and higher suicide attempt rates, but lower HDL-C and FBG levels. Further logistic regression indicated that duration of illness, HAMD score, TC, HDL-C, BMI, and FBG levels were significantly associated with TD.LimitationsNo causal relationship can be drawn due to the cross-sectional design.ConclusionTD is common in young FEDN MDD patients. So clinicians should monitor thyroid function in patients with MDD.

show abstract

Section: Introductionmentioning

confidence: 99%

Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors

Zhunian

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

From Weight Bias Internalization to Health-Related Quality of Life: Self-esteem and Psychopathology in Pre-bariatric Surgery Patients

et al. 2022

View full text Add to dashboard Cite

Introduction It has been reported that people seeking bariatric surgery have poor health-related quality of life (HRQoL). Weight bias internalization (WBI) is prevalent in this population and strongly associated with psychopathology and health status. However, the psychological mechanisms underlying the relationship between WBI and the physical and mental dimensions of HRQoL remain to be clarified. Methods A preoperative sample of patients with obesity (N = 246; women = 75.2%; Mage = 32.07) completed validated measures as part of a routine preoperative psychological assessment to assess their WBI, self-esteem, anxiety symptoms, depressive symptoms, and HRQoL. Results After controlling for the effects of gender, age, and BMI, WBI was linked to poorer physical and mental HRQoL through low self-esteem and increased psychological distress, including anxiety and depressive symptoms. Conclusion In pre-bariatric surgery patients with obesity, high WBI may predict impairments in mental and physical HRQoL by lowering self-esteem, and further increasing anxiety and depressive symptoms. Interventions targeting WBI may be an important aspect to consider in the clinical treatment of pre-bariatric surgery patients. Further longitudinal studies are warranted to determine causality. Graphical abstract

show abstract

Brain structural and functional alterations in individuals with combined overweight/obesity and mood disorders: A systematic review of neuroimaging studies

Zhang

Lin

et al. 2023

Journal of Affective Disorders

View full text Add to dashboard Cite

Using quantitative imaging to determine the correlation between hypothalamic inflammation and anxiety and depression in young patients with obesity

Cited by 4 publications

References 38 publications

Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors

Thyroid dysfunction in young, first-episode and drug-naïve patients with major depressive disorder: prevalence and associated clinical factors

From Weight Bias Internalization to Health-Related Quality of Life: Self-esteem and Psychopathology in Pre-bariatric Surgery Patients

Brain structural and functional alterations in individuals with combined overweight/obesity and mood disorders: A systematic review of neuroimaging studies

Contact Info

Product

Resources

About