Raman Spectroscopy and Applications 2017
DOI: 10.5772/65114
|View full text |Cite
|
Sign up to set email alerts
|

Using Raman Spectroscopy to Improve Hyperpolarized Noble Gas Production for Clinical Lung Imaging Techniques

Abstract: Spin-exchange optical pumping (SEOP) can be used to "hyperpolarize" 129Xe for human lung MRI. SEOP involves transfer of angular momentum from light to an alkali metal (Rb) vapor, and then onto 129 Xe nuclear spins during collisions; collisions between excited Rb and N 2 ensure that incident optical energy is nonradiatively converted into heat. However, because variables that govern SEOP are temperature-dependent, the excess heat can complicate efforts to maximize spin polarization-particularly at high laser fl… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
3
0

Year Published

2020
2020
2021
2021

Publication Types

Select...
2

Relationship

1
1

Authors

Journals

citations
Cited by 2 publications
(3 citation statements)
references
References 22 publications
0
3
0
Order By: Relevance
“…Although 3 He SEOP was reported by Bouchiat et al in 1960 [32], it was not until 1987 that Chupp et al attempted to model SEOP [1] under relatively simple conditions, involving a static cell with low laser power, and low Rb density.. However, underconditions needed for modern, practical continuous-flow SEOP, additional factors come into play [20].…”
Section: Theorymentioning
confidence: 99%
See 1 more Smart Citation
“…Although 3 He SEOP was reported by Bouchiat et al in 1960 [32], it was not until 1987 that Chupp et al attempted to model SEOP [1] under relatively simple conditions, involving a static cell with low laser power, and low Rb density.. However, underconditions needed for modern, practical continuous-flow SEOP, additional factors come into play [20].…”
Section: Theorymentioning
confidence: 99%
“…Steady improvements to SEOP technology such as the development of high-power, ultra-narrowed and tunable laser diode arrays, improved cell designs, and optimized cryogenic-collection chambers have enabled large volumes of polarized gas to be generated quickly, thus allowing hyperpolarized (HP) 129 Xe to emerge as a powerful magnetic-resonance tool. Consequently, this has enabled studies spanning fundamental atomic physics; nuclear magnetic resonance (NMR) spectroscopy [3]; highly sensitive biosensors [4][5][6][7]; dark matter research [8]; and magnetic resonance imaging (MRI) in animals and human subjects [9][10][11][12]. Such studies often demand that multiple doses of large volumes of highly-polarized 129 Xe gas be generated in a short time period (for example, in the case of in vivo MRI, this ranges from several hundreds of milliliters in preclinical and pediatric studies to several liters for adult studies, all within a human MRI scanning session of < 60 minutes).…”
Section: Introductionmentioning
confidence: 99%
“…The combination of these two spectroscopic techniques has been used to quantify the benefits of numerous scientific advances in the field . Such advances include better optical pumping efficiency and thermal management resulting from using high-power, frequency-narrowed laser diode arrays (LDAs), long-lived and reproducible polarization values and SEOP cell lifetimes arising from investigations into SEOP cell cleaning and preparation, ,− as well as more exotic studies into spin-exchange efficiency of hybrid alkali metal SEOP, , Rb cluster formation ,, and others. In most previous studies, NIR and NMR spectroscopic techniques have typically been performed using commercial instrumentation, which are often overengineered for the specific purposes described here.…”
mentioning
confidence: 99%