Using rigidly fixed autogenous tooth graft to repair bone defect: an animal model

Xu, Qian; Raj, Regmi M.; Liao, Xiao‐Fu; Shi, Wei; Ma, Bo; Shuili, Gong; Chen, Weimin; Zhou, Bin

doi:10.1111/edt.12101

Cited by 41 publications

(44 citation statements)

References 19 publications

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“…In large bone defects where a significant amount of the bony tissue has been lost, a direct injection method has been found to be ineffective for MSC delivery and the acceleration of the bone healing process [Qin et al, 2014a]. Recently, it has been suggested that the controlled delivery of MSCs and factors that promote healing within biomaterial carriers (hydrogel, scaffold, etc.)…”

Section: Tissue Engineering Approachesmentioning

confidence: 99%

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Oryan

Kamali²,

Moshiri³

et al. 2017

Cells Tissues Organs

291

204

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Healing and regeneration of bone injuries, particularly those that are associated with large bone defects, are a complicated process. There is growing interest in the application of osteoinductive and osteogenic growth factors and mesenchymal stem cells (MSCs) in order to significantly improve bone repair and regeneration. MSCs are multipotent stromal stem cells that can be harvested from many different sources and differentiated into a variety of cell types, such as preosteogenic chondroblasts and osteoblasts. The effectiveness of MSC therapy is dependent on several factors, including the differentiating state of the MSCs at the time of application, the method of their delivery, the concentration of MSCs per injection, the vehicle used, and the nature and extent of injury, for example. Tissue engineering and regenerative medicine, together with genetic engineering and gene therapy, are advanced options that may have the potential to improve the outcome of cell therapy. Although several in vitro and in vivo investigations have suggested the potential roles of MSCs in bone repair and regeneration, the mechanism of MSC therapy in bone repair has not been fully elucidated, the efficacy of MSC therapy has not been strongly proven in clinical trials, and several controversies exist, making it difficult to draw conclusions from the results. In this review, we update the recent advances in the mechanisms of MSC action and the delivery approaches in bone regenerative medicine. We will also review the most recent clinical trials to find out how MSCs may be beneficial for treating bone defects.

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Section: Tissue Engineering Approachesmentioning

confidence: 99%

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Oryan

Kamali²,

Moshiri³

et al. 2017

Cells Tissues Organs

291

204

View full text Add to dashboard Cite

show abstract

“…, Qin et al. ). Moreover, intentionally retained buccal root fragments also supported the osseointegration process by a new cementum formation (Hürzeler et al.…”

mentioning

confidence: 99%

Initial case report of an extracted tooth root used for lateral alveolar ridge augmentation

Schwarz

Schmucker

Becker

2016

J Clinic Periodontology

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“…[232425] Furthermore, the use of porous dentin scaffolds supports rapid microvascular ingrowth, as well as osseointegration, in mice, highlighting their potential as bone engineering materials. [26]…”

Section: Discussionmentioning

confidence: 99%

Demineralized dentin matrix scaffolds for alveolar bone engineering

Kim

Mitsugi

2017

J Indian Prosthodont Soc

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From the point of view of implant dentistry, this review discusses the development and clinical use of demineralized dentin matrix (DDM) scaffolds, produced from the patient's own extracted teeth, to repair alveolar bone defects. The structure and the organic and inorganic components of DDM are presented to emphasize the similarities with autogenous bone. Studies of DDM properties, such as osteoinductive and osteoconductive functions as well as efficacy and safety, which are mandatory for its use as a bone graft substitute, are also presented. The clinical applications of powder, block, and moldable DDM are discussed, along with future developments that can support growth factor and stem cell delivery.

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Using rigidly fixed autogenous tooth graft to repair bone defect: an animal model

Abstract: Rigid fixation of autogenous tooth could serve as a novel approach for the repair of bone defect.

Cited by 41 publications

References 19 publications

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Initial case report of an extracted tooth root used for lateral alveolar ridge augmentation

Demineralized dentin matrix scaffolds for alveolar bone engineering

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