The site effects relating to the amplification of ground motion under earthquake loading are strongly influenced by both the subsurface soil condition and the geologic structure. In this study, for site characterization at the Imam Khomeini International Airport (IKIA) area in south of Tehran, insitu seismic refraction tomography were carried out as a part of site investigations project, in addition geologic setting, borehole drilling, ground waters information and measurements. Based on seismic refraction studies, three layers are separable which with increasing in depth the S and P wave velocity is increased and this indicates increasing in compaction of soil and geologic materials. In the second and third separated layers, the zones with low and high seismic shear wave velocity is approximately equal, and northeast and southwest of the airport site has the low velocities, in addition to containing loose soils, highly weathered stones, and low depth to groundwater. In terms of Poisson's ratio, the most important and key installations of airport site are located in suitable positions. According to Iranian Seismic Code, most of the lands around the airport are in class 2 and 3. It seems that a fault or a discontinuity is passed from northwest to the southeast of the study area. This site, according to geological, subsurface geophysical, and geotechnical boreholes studies, is high risk-earthquake prone.