Using the Thickness Map from Macular Ganglion Cell Analysis to Differentiate Retinal Vein Occlusion from Glaucoma

Lee, Nam Ho; Park, Kee Sup; Lee, Han Min; Kim, Jung‐Yeul; Kim, Chang Sik; Kim, Kyoung Nam

doi:10.3390/jcm9103294

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…2B-C and S3 ). Various eye diseases are associated with retinal thinning 47 . Moreover, previous studies have consistently demonstrated the thinning of the RNFL and GCIPL to be associated with cerebrovascular diseases 48 and early-stage Alzheimer’s disease 49 .…”

Section: Resultsmentioning

confidence: 99%

Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

Zhao

Fan

et al. 2023

Preprint

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As an anatomical extension of the brain, the retina of the eye is synaptically connected to the visual cortex, establishing physiological connections between the eye and the brain. Despite the unique opportunity retinal structures offer for assessing brain disorders, less is known about their relationship to brain structure and function. Here we present a systematic cross-organ genetic architecture analysis of eye-brain connections using retina and brain imaging endophenotypes. Novel phenotypic and genetic links were identified between retinal imaging biomarkers and brain structure and function measures derived from multimodal magnetic resonance imaging (MRI), many of which were involved in the visual pathways, including the primary visual cortex. In 65 genomic regions, retinal imaging biomarkers shared genetic influences with brain diseases and complex traits, 18 showing more genetic overlaps with brain MRI traits. Mendelian randomization suggests that retinal structures have bidirectional genetic causal links with neurological and neuropsychiatric disorders, such as Alzheimer's disease. Overall, cross-organ imaging genetics reveals a genetic basis for eye-brain connections, suggesting that the retinal images can elucidate genetic risk factors for brain disorders and disease-related changes in intracranial structure and function.

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Section: Resultsmentioning

confidence: 99%

Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

Zhao

Fan

et al. 2023

Preprint

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“…Glaucomatous optic disc changes were defined as follows: diffuse or focal rim thinning, cupping, or retinal nerve fiber layer defects with corresponding VF defects. Glaucomatous VF defects were defined if they met two of the following three criteria: the presence of a cluster of three points on a pattern deviation probability plot at p < 0.05, one of which was at p < 0.01, a pattern standard deviation at p < 0.05, or glaucoma hemifield test results outside normal limits [10][11][12].…”

Section: Methodsmentioning

confidence: 99%

Effects of Topical Anti-Glaucoma Medications on Outcomes of Endoscopic Dacryocystorhinostomy: Comparison with Age- and Sex-Matched Controls

Lee,

Lim,

et al. 2024

JCM

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Background: This study analyzed the effects of topical anti-glaucoma medications on the surgical outcomes of endoscopic dacryocystorhinostomy (EDCR) in nasolacrimal duct obstruction (NLDO). Methods: This retrospective study included patients who underwent EDCR for NLDO between September 2012 and April 2021. Thirty patients with topical anti-glaucoma medications and 90 age- and sex-matched controls were included. Results: The success rate of EDCR was higher in the control group than in the anti-glaucoma group (97.8% vs. 86.7%, p = 0.034). Univariate and multivariate logistic regression analyses identified prostaglandin analogs as the most influential risk factor for EDCR success among anti-glaucoma medication ingredients (p = 0.005). The success rate of the group containing all four anti-glaucoma medication ingredients was statistically significant (p = 0.010). The success rate was significantly different in the group of patients who used anti-glaucoma medication for >24 months (p = 0.019). When multiplying the number of drug ingredients by the duration in months, the group > 69 showed a significantly decreased success rate (p = 0.022). Multivariate logistic regression analysis identified the number of anti-glaucoma medications as the most significant risk factor for EDCR success (odds ratio, 0.437; 95% confidence interval, 0.247 to 0.772; p = 0.004). Conclusions: The authors suggest that the anti-glaucoma medications might cause NLDO and increase the failure rate after EDCR. Therefore, when performing EDCR in patients using topical anti-glaucoma medications, surgeons should consider the possibility of increased recurrence after EDCR in clinical outcomes.

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Eye-brain connections revealed by multimodal retinal and brain imaging genetics

Zhao,

Li,

Fan

et al. 2024

Nat Commun

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The retina, an anatomical extension of the brain, forms physiological connections with the visual cortex of the brain. Although retinal structures offer a unique opportunity to assess brain disorders, their relationship to brain structure and function is not well understood. In this study, we conducted a systematic cross-organ genetic architecture analysis of eye-brain connections using retinal and brain imaging endophenotypes. We identified novel phenotypic and genetic links between retinal imaging biomarkers and brain structure and function measures from multimodal magnetic resonance imaging (MRI), with many associations involving the primary visual cortex and visual pathways. Retinal imaging biomarkers shared genetic influences with brain diseases and complex traits in 65 genomic regions, with 18 showing genetic overlap with brain MRI traits. Mendelian randomization suggests bidirectional genetic causal links between retinal structures and neurological and neuropsychiatric disorders, such as Alzheimer’s disease. Overall, our findings reveal the genetic basis for eye-brain connections, suggesting that retinal images can help uncover genetic risk factors for brain disorders and disease-related changes in intracranial structure and function.

show abstract

Using the Thickness Map from Macular Ganglion Cell Analysis to Differentiate Retinal Vein Occlusion from Glaucoma

Cited by 3 publications

References 33 publications

Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

Eye-brain connections revealed by multimodal retinal and brain imaging genetics in the UK Biobank

Effects of Topical Anti-Glaucoma Medications on Outcomes of Endoscopic Dacryocystorhinostomy: Comparison with Age- and Sex-Matched Controls

Eye-brain connections revealed by multimodal retinal and brain imaging genetics

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