Using virtual reality to characterize episodic memory profiles in amnestic mild cognitive impairment and Alzheimer's disease: Influence of active and passive encoding

Plancher, Gaën; Tirard, A.; Gyselinck, Valérie; Nicolas, Serge; Piolino, Pascale

doi:10.1016/j.neuropsychologia.2011.12.013

Cited by 242 publications

(224 citation statements)

References 95 publications

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“…Similarly, we developed a route video task to assess visuospatial memory, because similar tasks have been shown to have greater ecological validity than pen-and-paper visual memory measures (Barbeau et al, 2006;Tramoni et al, 2011). It has also been suggested that route-task performance is correlated with patients' subjective memory complaints, and thus may be useful in clinical assessment (Plancher, Tirard, Gyselinck, Nicolas, & Piolino, 2012).…”

Section: Neuropsychological Testsmentioning

confidence: 99%

Forgetting in temporal lobe epilepsy: When does it become accelerated?

Cassel

Morris

Koutroumanidis

et al. 2016

Cortex

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The notion of 'accelerated long-term forgetting' has often been attributed to disrupted 'late' memory consolidation. Nevertheless, methodological issues in the literature have left this theory unproven, leading some to suggest such findings may be reflective of subtle acquisition or early retention deficits. This study attempts to address such issues, and also to explore which pathophysiological variables are associated with forgetting rates. Eighteen participants with temporal lobe epilepsy (TLE) and eighteen matched controls completed background neuropsychological measurement of immediate and short-delay memory that showed comparable performance, both on verbal and visual tests. Using two novel experimental tasks to measure long-term forgetting, cued recall of verbal and visuospatial material was tested 30 seconds, 10 minutes, one day, and one week after learning. Forgetting of verbal material was found to be progressively faster during the course of a week in the TLE group. For visuospatial memory, participants in the TLE group exhibited faster early forgetting in the first 10 minutes after learning, as indicated by planned comparisons, with comparable forgetting rates thereafter. Our findings provide evidence for two patterns of disruption to 'early' memory consolidation in this population, occurring either at the initial delay only or continuing progressively through time. Differences in how soon after learning accelerated forgetting was detectable were related to factors associated with greater severity of epilepsy, such as presence of medial temporal lobe sclerosis on MRI and use of multiple anti-epileptic agents.

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Section: Neuropsychological Testsmentioning

confidence: 99%

Forgetting in temporal lobe epilepsy: When does it become accelerated?

Cassel

Morris

Koutroumanidis

et al. 2016

Cortex

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“…Recent studies in humans have shown that WWW memories are reliably reported as "remembered" rather than "known" (Holland and Smulders 2011;Easton et al 2012;Cheke and Clayton 2013) and are correlated with, but distinct from, free recall performance Clayton 2013, 2015;Mazurek et al 2015). However, evidence for aging effects using WWW is mixed (Plancher et al 2010(Plancher et al , 2012Mazurek et al 2015).The treasure-hunt task further differs from other episodic memory tests because the encoding period allows individuals to "hide" items themselves . This is significant because agentic involvement in the encoding of items aids recollection (Plancher et al 2012) and gets closer to memory encoding in everyday life (one does not passively observe the location of one's keys, but actively places them).…”

mentioning

confidence: 99%

“…However, evidence for aging effects using WWW is mixed (Plancher et al 2010(Plancher et al , 2012Mazurek et al 2015).…”

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confidence: 99%

What–where–when memory and encoding strategies in healthy aging

Cheke

2016

Learn. Mem.

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Older adults exhibit disproportionate impairments in memory for item-associations. These impairments may stem from an inability to self-initiate deep encoding strategies. The present study investigates this using the "treasure-hunt task"; a whatwhere-when style episodic memory test that requires individuals to "hide" items around complex scenes. This task separately assesses memory for item, location, and temporal order, as well as bound what-where-when information. The results suggest that older adults are able to ameliorate integration memory deficits by using self-initiated encoding strategies when these are externally located and therefore place reduced demands on working memory and attentional resources.In everyday life, it is often only when remembered elements of information are integrated into a single memory that they are functionally useful. You may know that you have met someone before, but if you do not remember the context-"where" and "when" you met them-you cannot be said to know "who they are." Normal aging is thought to affect memory for these various types of information differently, and to have a particular impact on memory integration (Spencer and Raz 1995;Kessels et al. 2007;Blachstein et al. 2012). There are two main theories as to the source of these deficits. In the "associative deficit hypothesis" Naveh-Benjamin (2000) argues older adults are less able to create and retrieve links between single units of information (Chalfonte and Johnson 1996;Naveh-Benjamin 2000;Naveh-Benjamin et al. 2007). In contrast, the "hyperbinding hypothesis" (Campbell et al. 2010(Campbell et al. , 2014 suggests that older adults may be unable to down-regulate attention to irrelevant information, instead dispersing their attention across other information in the study environment that is spatially (e.g., other things in the scene) or temporally (e.g., the previous trial) close to target items. As such the correct associations are encoded, but associations are also encoded between distractor items or irrelevant environmental features, making retrieval of the target information more difficult. Both theories suggest that these impairments may be exacerbated by a failure to adopt appropriate encoding strategies. There is considerable evidence that reduced working memory resources among older adults restrict the formation of deep encoding operations, resulting in a failure to carry out "self-initiated" encoding strategies (Salthouse and Babcock 1991;Salthouse 1996;Craik and Rose 2012). However, older adults are able to benefit from encoding strategies if instructed to engage in them (Logan et al. 2002;Morcom et al. 2003).Classical neuropsychological tools used to assess episodic memory in aging often fail to encompass the complexity of memory as it is experienced in everyday life (Piolino et al. 2009). Furthermore, episodic memory is generally assessed with verbal tasks, while most everyday memories concern visual and action information. The present study uses a what-where -when-style memory test (the treasure-hunt tas...

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“…In a recent study in 2012 [9], the authors implemented a simple driving simulation with PC and a projector, which allows a user to navigate a virtual city or town passively as a passenger or actively as a driver. After the exploration, participants' episodic memory about the virtual place was tested in recall and recognition questions.…”

Section: Vr Applications For Rehabilitation Assessmentmentioning

confidence: 99%

Virtual Reality Applications in Rehabilitation

Cao

2016

Lecture Notes in Computer Science

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Abstract.One of the most valuable applications of virtual reality (VR) is in the domain of rehabilitation. After brain injuries or diseases, many patients suffer from impaired physical and/or cognitive capabilities, such as difficulties in moving arms or remembering names. Over the past two decades, VR has been tested and examined as a technology to assist patients' recovery and rehabilitation, both physical and cognitive. The increasing prevalence of low-cost VR devices brings new opportunities, allowing VR to be used in practice. Using VR devices such as head-mounted displays (HMDs), special virtual scenes can be designed to assist patients in the process of re-training their brain and reorganizing their functions and abilities. However, such VR interfaces and applications must be comprehensively tested and examined for their effectiveness and potential side effects. This paper presents a review of related literature and discusses the new opportunities and challenges. Most of existing studies examined VR as an assessment method rather than a training/exercise method. Nevertheless, promising cases and positive preliminary results have been shown. Considering the increasing need for self-administered, home-based, and personalized rehabilitation, VR rehabilitation is potentially an important approach. This area requires more studies and research effort.

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Using virtual reality to characterize episodic memory profiles in amnestic mild cognitive impairment and Alzheimer's disease: Influence of active and passive encoding

Cited by 242 publications

References 95 publications

Forgetting in temporal lobe epilepsy: When does it become accelerated?

Forgetting in temporal lobe epilepsy: When does it become accelerated?

What–where–when memory and encoding strategies in healthy aging

Virtual Reality Applications in Rehabilitation

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