Using wavelet analysis to reveal the muscle functional recovery following nerve reinnervation in a rat model

Zhou, Hui; Yang, Lin; Zhang, Liangqing; Wu, Fengxia; Huang, Jianping; Li, Guanglin

doi:10.1109/embc.2014.6944142

Cited by 3 publications

References 13 publications

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Satellite Cells and Neuromuscular Spindles in Long Term Denervated Skeletal Muscles

Shinohara

Melo

Ahmed

et al. 2021

Preprint

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Satellite cells (SC) are quiescent cell located between the sarcolemma and basal lamina of the skeletal muscle fibers. The SC can get activated contributing to regeneration and/or growth of muscle. The neuromuscular spindles are mechanoreceptors located within the skeletal muscle and are considered as contractile regulatory unit. It is composed of intrafusal muscle fibers (IF), surrounded by a sheath and is parallel to extrafusal fibers. Denervation cause changes in skeletal muscles both in the SC and neuromuscular spindles. This study analyzed quantitatively the IF and SC in Wistar rats denervated for long period. The animals were divided into normal and denervated groups. The soleus and extensor longus digitorum longus were denervated experimentally during periods of 0, 12, 16, 19, 30 and 38 weeks. The percentage of SC immediately after denervation increases when compared to normal group and later decreases in both the groups. During the process of denervation, there was an increase in IF when compared with normal group. The percentage of SC reduces significantly between the periods of denervation in both the groups. The smaller percentage of SC corresponds to higher number of IF. Besides that the number of SC decreases after denervation. As for IF, with the increase in time in normal group, the number of fibers was unaltered. However, in the experimental group, with increase in the time of denervation, the percentage of SC decreases while there is increase in the number of IF significantly. In denervated muscles for long period, there is decrease in the percentage of SC and increase in IF. Our results suggest that the period between 16th and 19th week post denervation is the best time for reinnervation of denervated muscle.

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Satellite Cells and Neuromuscular Spindles in Long Term Denervated Skeletal Muscles

Shinohara

Melo

Ahmed

et al. 2021

Preprint

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Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation

Zhong

et al. 2022

Cyborg Bionic Syst

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Targeted muscle reinnervation (TMR) is a microsurgical repair technique to reconstruct the anatomical structure between the distal nerve and the muscle stump to provide more myoelectric information to the artificially intelligent prosthesis. Postoperative functional electrical stimulation treatment of the patient’s denervated muscle or proximal nerve stump as well as nerve growth factor injection is effective in promoting nerve regeneration and muscle function recovery. In this experiment, we successfully established a TMR rat model and divided Sprague-Dawley (SD) adult male rats into TMR group, TMR + FES group, and TMR + NGF group according to TMR and whether they received FES treatment or NGF injection after surgery, and the recovery effect of rat neuromuscular function was assessed by analyzing EMG signals. Through the experiments, we confirmed that growth factor supplementation and low-frequency electrical stimulation can effectively promote the regeneration of the transplanted nerve as well as significantly enhance the motor function of the target muscle and have a positive effect on the regeneration of the transplanted nerve.

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Nerve function restoration following targeted muscle reinnervation after varying delayed periods

Huang

Chen

et al. 2023

Neural Regeneration Research

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Using wavelet analysis to reveal the muscle functional recovery following nerve reinnervation in a rat model

Cited by 3 publications

References 13 publications

Satellite Cells and Neuromuscular Spindles in Long Term Denervated Skeletal Muscles

Satellite Cells and Neuromuscular Spindles in Long Term Denervated Skeletal Muscles

Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation

Nerve function restoration following targeted muscle reinnervation after varying delayed periods

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