Uso de Palivizumab en Recién Nacidos Prematuros

Martínez, Larissa Maydelin Contreras; Márquez, Marlon Alexander Cerna

doi:10.5377/pediatrica.v9i2.8790

Act Ped Hond

2019

DOI: 10.5377/pediatrica.v9i2.8790

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Uso de Palivizumab en Recién Nacidos Prematuros

Larissa Maydelin Contreras Martínez

Marlon Alexander Cerna Márquez²

Abstract: El Palivizumab es una terapia biológica perteneciente a la familia de los anticuerpos monoclonales IgG, indicado para la prevención de enfermedad respiratoria inferior grave causada por el Virus Sincitial Respiratorio (VSR) en neonatos prematuros con factores de riesgo. Los recién nacidos pretérminos (RNPT) se consideran los más susceptibles a dichas enfermedades en comparación con los recién nacidos a términos (RNT) sanos, lo que se traduce en mayores ingresos a Unidades De Cuidados intensivos Neonatales (UC… Show more

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2024

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Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis

Ciapponi,

Palermo,

Sandoval

et al. 2024

Front. Public Health

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BackgroundRespiratory Syncytial Virus (RSV) is a common cause of lower respiratory tract infections (LRTI) and hospitalization worldwide. The impact of RSV in Latin America and the Caribbean (LAC) including expensive treatment options, such as palivizumab, have been extensively discussed. However, publications on the impact of RSV disease burden in the region are scarce. This systematic review aimed to determine the incidence and prevalence of RSV in LAC by age and RSV subtype.MethodsWe conducted a systematic review following Cochrane methods to evaluate the disease burden of RSV in LAC countries. We searched studies from January 2012 to January 2023 in literature databases and grey literature without language restrictions. We included guidelines, observational, economic, and surveillance studies from LAC countries. Pairs of reviewers independently selected, and extracted data from included studies. The risk of bias was assessed using the Study Quality Assessment Tools (NHLBI) and AGREE-II. We performed proportion meta-analyses using methods to stabilize the variance. The protocol was registered in PROSPERO (CRD42023393731).ResultsWe included 156 studies, mainly from Brazil (25%), Colombia (14.5%), and Argentina (13.8%), as well as four clinical practice guidelines. Most studies were cross-sectional (76.9%) and were classified as low risk of bias (52.6%). The majority included inpatients (85.6%), pediatric (73.7%), and normal-risk patients (67.1%). The highest pooled prevalence was estimated in patients <1 year old (58%), with type A and B prevalence of 52 and 34%, respectively. The RSV-LRTI incidence was 15/100 symptomatic infants aged <2 years old, and the ICU admission was 42%. The RSV-LRTI lethality was 0.6, 3% in patients aged <2 and 0–5 years old, respectively, and 23% among >65 years old high-risk patients. The identified guidelines lack methodological rigor and have limitations in their applicability. The seasonality was more evident in South America than in Central America and The Caribbean, with a clear gap during the pandemic.ConclusionThis is the most exhaustive and updated body of evidence describing a significant burden of RSV in LAC, particularly at the extremes of life, and its seasonality patterns. Our findings could contribute could contribute facilitating effective prevention and treatment strategies for this significant public health problem.Systematic review registrationPROSPERO CRD UK (registration number: CRD42023393731).

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Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis

Ciapponi,

Palermo,

Sandoval

et al. 2024

Front. Public Health

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show abstract

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Uso de Palivizumab en Recién Nacidos Prematuros

Cited by 1 publication

References 13 publications

Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis

Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis

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