USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53

Yuan, Jiahui; Li, Xiaomei; Zhang, Yuqi; Zhang, Gongye; Cheng, Weipeng; Wang, Weiwei; Lei, Yongbin; Song, Gang

doi:10.1007/s10565-021-09683-0

Cited by 11 publications

(4 citation statements)

References 35 publications

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“…USP39 has been identified as participating in tumorigenesis. For instance, USP39 silencing enhanced cisplatin‐induced apoptosis in colon cancer cells by increasing p53 expression [ 24 ]. USP39 deficiency activates p53 pathway–induced apoptosis and metastasis in NSCLC [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression

Hou,

Chen,

Wang

2024

Clinical Respiratory J

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BackgroundMitochondrial ribosomal protein L35 (MRPL35) has been reported to contribute to the growth of non–small cell lung cancer (NSCLC) cells. However, the functions and mechanisms of MRPL35 on glutamine metabolism in NSCLC remain unclear.MethodsThe detection of mRNA and protein of MRPL35, ubiquitin‐specific protease 39 (USP39), and solute carrier family 7 member 5 (SLC7A5) was conducted using qRT‐PCR and western blotting. Cell proliferation, apoptosis, and invasion were evaluated using the MTT assay, EdU assay, flow cytometry, and transwell assay, respectively. Glutamine metabolism was analyzed by detecting glutamine consumption, α‐ketoglutarate level, and glutamate production. Cellular ubiquitination analyzed the deubiquitination effect of USP39 on MRPL35. An animal experiment was conducted for in vivo analysis.ResultsMRPL35 was highly expressed in NSCLC tissues and cell lines, and high MRPL35 expression predicted poor outcome in NSCLC patients. In vitro analyses suggested that MRPL35 knockdown suppressed NSCLC cell proliferation, invasion, and glutamine metabolism. Moreover, MRPL35 silencing hindered tumor growth in vivo. Mechanistically, USP39 stabilized MRPL35 expression by deubiquitination and then promoted NSCLC cell proliferation, invasion, and glutamine metabolism. In addition, MRPL35 positively affected SLC7A5 expression in NSCLC cells in vitro and in vivo. Moreover, the anticancer effects of MRPL35 silencing could be rescued by SLC7A5 overexpression in NSCLC cells.ConclusionMRPL35 expression was stabilized by USP39‐induced deubiquitination in NSCLC cells, and knockdown of MRPL35 suppressed NSCLC cell proliferation, invasion, and glutamine metabolism in vitro and impeded tumor growth in vivo by upregulating SLC7A5, providing a promising therapeutic target for NSCLC.

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Section: Discussionmentioning

confidence: 99%

MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression

Hou,

Chen,

Wang

2024

Clinical Respiratory J

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“…According to the WHO, lung, breast, colorectal, and prostate cancers stand out as the most common ones, whilst lung cancer has the highest mortality rates [55]. At present, although there are some treatments available for this disease, they are usually associated with detrimental side effects, drug resistance, reduced treatment adherence, and a decreased quality of life for the patients [56][57][58][59][60]. There is unquestionably a major unmet need in this regard, thereby a plethora of studies are dedicated to discovering different strategies for treating cancer.…”

Section: Sodium Selenite and Cancermentioning

confidence: 99%

Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

et al. 2022

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Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe−/H2Se) and methylselenol (CH3SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies.

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“…2 Cisplatin (CP) is one of the most effective cytotoxic agents in CRC chemotherapy; however, its therapeutic efficacy is limited by chemoresistance and detrimental side effects. 3 Hence, there remains a need for effective therapeutic approaches to improve the CP sensitivity in CRC. Recent scientific evidence has shown that CP induces ferroptosis and apoptosis in CRC cells and that the combination of CP and the ferroptosis inducer erastin is effective in enhancing the antitumor activity of drugs.…”

Section: Introductionmentioning

confidence: 99%

Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

Cai

Luo²,

Chen

et al. 2023

Food Funct.

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USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53

Cited by 11 publications

References 35 publications

MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression

MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression

Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis

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