Uterine B cell lymphoma in a mare

Claes, A.; Ball, Barry A.; Liu, I. K. M.; Vaughan, Betsy; Highland, Margaret A.; Brown, Jared A

doi:10.1111/j.2042-3292.2012.00431.x

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Lymphoma most frequently involves lymphoid, abdominal and thoracic organs followed by skin (Meyer et al 2006) but cases have also been described in the uterus (Claes et al 2015), and limbs (Moser et al 2014). In one study of gastrointestinal neoplasia in the horse, lymphoma was the most common diagnosis (Taylor et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Large B‐cell lymphoma in the colon and mesocolon of a Thoroughbred racehorse: Detection prior to development of clinical signs using clinicopathological markers of inflammation

Hill

Kelly

Davis

et al. 2018

Equine Veterinary Education

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Summary In this report, we describe an investigation into the cause of chronic inflammation in a clinically normal 5‐year‐old racing Thoroughbred, finally confirmed to be associated with B‐cell lymphoma. Over a 14‐week period, the horse was regularly evaluated by sequential blood testing, revealing persistent inflammation of unknown origin, unresponsive to treatment. Eventually, an abdominal mass was identified by transabdominal ultrasound and rectal palpation. Surgical exploration revealed an extensive, invasive soft tissue mass in the abdomen. At post‐mortem examination, a mass involving the colon, mesocolon and mesocolonic lymph node was sampled and confirmed as a large B‐cell lymphoma by histopathology and immunohistochemistry. In cases of unexplained chronic inflammation in a horse, neoplasia should be considered as a possible aetiology.

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Section: Discussionmentioning

confidence: 99%

Large B‐cell lymphoma in the colon and mesocolon of a Thoroughbred racehorse: Detection prior to development of clinical signs using clinicopathological markers of inflammation

Hill

Kelly

Davis

et al. 2018

Equine Veterinary Education

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“…Uterine lymphomas have been described uncommonly in other animal species (Tanaka et al 2003;Burton et al 2010;Claes et al 2015;Diaz-Delgado et al 2015), and in cattle they are most commonly found in association with the bovine leukaemia virus (Olson and Baumgartener 1976;Burton et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Uterine B-cell lymphoma in two dogs – a case report

Novotný¹,

Taylor²,

Claxton³

et al. 2017

Acta Vet. Brno

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Uterine lymphoma is rare in the dog, in other animal species, and in humans. The lymphoma in the two female dogs presented as a primary tumour of uterine tissue and was classified as diffuse centroblastic B cell lymphoma. Terminally, the uterine lymphoma metastasized to various organs in one of the dogs, despite chemotherapy. This case study describes a very rare form of canine lymphoma and suggests to include lymphoma in the differential diagnoses in bitches with uterine masses.

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“…In addition, an endometrial fibrosarcoma with invasion in the myometrium; tumor cell emboli in lymphatics; and metastases in lungs, liver, and spleen is described in an 18-year-old Warmblood mare [91]. Other published neoplasms with involvement of the endometrium are multicentric lymphosarcomas, i.e., T-cell lymphosarcoma in a 22-year-old pony mare [92] as well as B-cell lymphosarcomas in a 5-year-old Quarter horse mare [93] and an 8-year-old Thoroughbred mare [94].…”

Section: Endometrial Cancer: a Rare Disease In Maresmentioning

confidence: 99%

The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses

Schöniger¹,

Schoon

2020

Animals

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Mares are seasonally polyestric. The breeding season in spring and summer and the winter anestrus are flanked by transitional periods. Endometrial diseases are a frequent cause of subfertility and have an economic impact on the horse breeding industry. They include different forms of endometrosis, endometritis, glandular maldifferentiation, and angiosis. Except for suppurative endometritis, these are subclinical and can only be diagnosed by the microscopic examination of an endometrial biopsy. Endometrosis is characterized by periglandular fibrosis and nonsuppurative endometritis by stromal infiltration with lymphocytes and plasma cells. The pathogenesis of endometrosis and nonsuppurative endometritis is still undetermined. Some mares are predisposed to persistent endometritis; this has likely a multifactorial etiology. Glandular differentiation has to be interpreted under consideration of the season. The presence of endometrial diseases is associated with alterations in the expression of several intra- and extracellular molecular markers. Some of them may have potential to be used as diagnostic biomarkers for equine endometrial health and disease. The aim of this review is to provide an overview on pathomorphological findings of equine endometrial diseases, to outline data on analyses of cellular and molecular mechanisms, and to discuss the impact of these data on reproduction and treatment.

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Uterine B cell lymphoma in a mare

Cited by 4 publications

References 22 publications

Large B‐cell lymphoma in the colon and mesocolon of a Thoroughbred racehorse: Detection prior to development of clinical signs using clinicopathological markers of inflammation

Large B‐cell lymphoma in the colon and mesocolon of a Thoroughbred racehorse: Detection prior to development of clinical signs using clinicopathological markers of inflammation

Uterine B-cell lymphoma in two dogs – a case report

The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses

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