Uterine cervical squamous cell carcinoma with reactive multinucleated giant cells expressing cluster of differentiation 204: A case report and literature review

Dejima, Mihiro; Hashimoto, Hirotsugu; Sasajima, Yuko; Nomura, Nao; Sugita, Masatoshi; Morikawa, Teppei

doi:10.1111/jog.14404

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As is well known, the vast majority of cervical SCCs are associated with high-risk HPV genotypes, of which 70% are caused by types 16 and 18. In the cases of SCC with OGCs reported to date, PCR for HPV detection has been performed in only three of them, and just two were HPV related, with association to types 16 (case 6) ( 8 ) and 34 (present case) ( Table I ). HPV type 34, in contrast to type 16, is reported in the literature as a probable high oncogenic risk genotype and is less frequently found.…”

Section: Discussionmentioning

confidence: 89%

“…Despite their rarity, these unique cells have captured attention due to their potential diagnostic significance and implications for tumor biology. To the best of our knowledge, only six cases of SCCs with OGCs in the uterine cervix have been reported to date (4)(5)(6)(7)(8). This limited incidence underscores the importance of meticulous observation and thorough histopathological examination to identify and characterize such atypical tumor features within the cervix.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Squamous cell carcinoma of uterine cervix with osteoclast‑like giant cells: A case report

Castillo,

Perelló‑Fabregat,

García‑Gómez

et al. 2024

Mol Clin Oncol

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) is a common tumor of the uterine cervix, usually related to human papillomavirus (HPV). While osteoclast-like giant cells (OGCs) have been reported to be associated with tumors at various locations, to the best of our knowledge, only six cases have been reported in the cervix to date. The present study describes the case of a 38-year-old woman with a medical history of ectopic pregnancy and vaginal childbirth, who presented with coitorrhagia. On physical examination, a mass of ~4 cm was found in the uterine cervix. A biopsy of this lesion revealed infiltrating SCC, leading to a radical hysterectomy 2 months later. The surgical specimen displayed an exophytic lesion with a maximum diameter of 3.5 cm confined to the uterine cervix, histologically consistent with an infiltrating non-keratinizing SCC. There was a prominent intra- and peritumoral chronic inflammatory reaction, and a high number of OGCs. Immunohistochemically, tumoral cells were positive for cytokeratin βE12, epithelial membrane antigen, p40, p63 and p16, and negative for CD68, vimentin and CD163. OGCs exhibited an inverted expression pattern, with positivity only for histiocytic markers. PCR for HPV detection revealed a HPV 34 genotype (probable high oncogenic risk). This profile suggests the non-neoplastic nature of OGCs, i.e. they should be considered as part of the immune response to the tumor. To the best of our knowledge, this case is the seventh instance of SCC with OGCs in the uterine cervix. Similar findings in other organs, such as the breast, pancreas or stomach, have been associated with a favorable prognosis. While two of the three reported cases with poor outcomes in the uterine cervix had an associated sarcomatoid component, the limited number of cases described to date in this location does not yet allow for an accurate prediction of behavior.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 98%

Squamous cell carcinoma of uterine cervix with osteoclast‑like giant cells: A case report

Castillo,

Perelló‑Fabregat,

García‑Gómez

et al. 2024

Mol Clin Oncol

View full text Add to dashboard Cite

show abstract

Tumor associated macrophage in HPV+ tumors: Between immunosuppression and inflammation

Gorvel

Olive

2023

Seminars in Immunology

View full text Add to dashboard Cite

Development and Validation of A ferroptosis-Related Model for Three Digestive Tract Tumors Based on a Pan-Cancer Analysis

Zhang

Akuetteh

et al. 2021

Epigenomics

View full text Add to dashboard Cite

Aims: To develop a ferroptosis gene-based survival-predictor model for predicting the prognosis of patients with digestive tract tumors, a pan-caner analysis was performed. Materials & methods: Based on unsupervised clustering and the expression levels of ferroptosis genes, patients with cancer were divided into two clusters. The least absolute shrinkage and selection operator method Cox regression analysis was used to establish the survival-predictor model. Results: Based on the pan-cancer analysis, a 20 gene-based survival-predictor model for predicting survival rates was developed, which was validated in patients with hepatocellular carcinoma. Conclusion: The survival-predictor model accurately predicted the prognosis of patients with digestive tract tumors.

show abstract

Uterine cervical squamous cell carcinoma with reactive multinucleated giant cells expressing cluster of differentiation 204: A case report and literature review

Cited by 3 publications

References 15 publications

Squamous cell carcinoma of uterine cervix with osteoclast‑like giant cells: A case report

Squamous cell carcinoma of uterine cervix with osteoclast‑like giant cells: A case report

Tumor associated macrophage in HPV+ tumors: Between immunosuppression and inflammation

Development and Validation of A ferroptosis-Related Model for Three Digestive Tract Tumors Based on a Pan-Cancer Analysis

Contact Info

Product

Resources

About