Uterine Cytokine Profile in a Rat Model of Endometritis

Abstract

High expression of CINCs as well IL-1a and CXCL5/LIX suggests their potent roles in the pathogenicity of endometritis.

Nisin reduces uterine inflammation in rats by modulating concentrations of pro‐ and anti‐inflammatory cytokines

“…The animal model of clinical endometritis is of great significance in the prevention and treatment of endometrial inflammation . Upon infection, the immune response of the endometrium toward the pathogen can be activated, triggering the release of cytokines and chemokines from endometrial cells to resist the infection of pathogenic bacteria.…”

Amelioration ofEscherichia coli‐induced endometritis with ascorbic acid in non‐pregnant mouse models

“…21 This can often present as an increase in the occurrence and duration of the oestrous phases. 22 As the course of several infections is followed by the immunity activation process, 23 the oestrous cycle inhibition during infection may be an indirect consequence of the early immune response activation. 21 The interactions between the endocrine and the immune systems have been investigated and established.…”

“…33 The effect of endometritis and treatment regimen in this study could be clearly seen in uterine activity and function of the animals (Figure 2). Lipopolysaccharide (LPS) produced from E. coli infection has been reported to induce inflammatory responses in the myometrium by activation of Toll-like receptor 4 (TLR4) which results in the release of pro-inflammatory cytokines in the myometrium, 23 and interleukin (IL)-1β itself has been shown to facilitate ligand-induced basal and store-operated calcium entry, thus potentiating myocyte contraction. Lipopolysaccharide (LPS) produced from E. coli infection has been reported to induce inflammatory responses in the myometrium by activation of Toll-like receptor 4 (TLR4) which results in the release of pro-inflammatory cytokines in the myometrium, 23 and interleukin (IL)-1β itself has been shown to facilitate ligand-induced basal and store-operated calcium entry, thus potentiating myocyte contraction.…”

“…The rhythmic intrinsic myometrial contraction seen in the no-endometritis and no-treatment group was markedly altered resulting in an increase in frequency and tension of contractility (Figure 3) in the endometritis no-treatment group which may have also induced hyperalgesia in the animals. Lipopolysaccharide (LPS) produced from E. coli infection has been reported to induce inflammatory responses in the myometrium by activation of Toll-like receptor 4 (TLR4) which results in the release of pro-inflammatory cytokines in the myometrium, 23 and interleukin (IL)-1β itself has been shown to facilitate ligand-induced basal and store-operated calcium entry, thus potentiating myocyte contraction. 34 In addition, LPS induces production of known contractile effectors, such as prostaglandins.…”

Alterações patológicas do sistema genital de cutias (Dasyprocta aguti Linnaeus, 1758) fêmeas criadas em cativeiro

“…Entre as alterações patológicas do sistema reprodutivo de cutias que mais se destacaram, foram localizadas no útero, sendo a endometrite observada em maior frequência. A endometrite é o processo inflamatório mais frequente no útero de diversas fêmeas domésticas que interfere negativamente na eficiência reprodutiva, aumentando a ocorrência de repetição de cio, intervalos entre partos e a taxa de refugo (Wagener et al 2014, Pothmann et al 2015, Xu et al 2015. Neste estudo, as alterações encontradas como fator predisponente à endometrite foram retenção de placenta, abortamento e maceração fetal.…”