Uterine fibroid incidence and growth in an ultrasound-based, prospective study of young African Americans

Baird, Donna D.; Patchel, Stacy A; Saldana, Tina M.; Umbach, David M.; Cooper, Tracy; Wegienka, Ganesa; Harmon, Quaker E.

doi:10.1016/j.ajog.2020.02.016

Cited by 60 publications

(64 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies connected low levels of serum vitamin D and UF occurrence. Most of those studies focused on AA women, who have an increased risk of UF development [88][89][90]. Those populations have a 10 times higher risk of vitamin D deficiency and a 3-to 4-fold higher incidence of UFs compared to Caucasians [91].…”

Section: Vitamin D and Uterine Fibroids-available Clinical Datamentioning

confidence: 99%

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

et al. 2020

View full text Add to dashboard Cite

Uterine fibroids (UFs) are benign tumors originating from smooth muscle cells and are considered a common pathology that affects numerous women which is a notable socio-economic problem. Several UF risk factors have been identified including black race, obesity, and vitamin D deficiency. Vitamin D is steroid compound with pleiotropic effects on the human body. Vitamin D deficiency is a major public health concern worldwide. Several studies have shown that the majority of UF patients experienced hypovitaminosis D. In addition, sufficient vitamin D serum levels are associated with the reduced risk of UFs. In this review, we present available data highlighting the importance of measuring vitamin D serum levels in women with UFs and women at a high risk for UF development. We proposed a preliminary clinical instruction of 25-hydroxyvitamin D measurements and vitamin D supplementation for clinicians who are involved in the treatment of patients with UFs. Achieving sufficient serum levels of vitamin D might be of interest in patients with UFs. Screening, supplementation, treatment guidelines, and public health strategies for vitamin D deficiency in women with UFs as well as women at a high risk of UF development might be of potential importance as well.

show abstract

Section: Vitamin D and Uterine Fibroids-available Clinical Datamentioning

confidence: 99%

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Approximately 30%–35% of women will be diagnosed with fibroids using ultrasound detection, but over 70% of women are estimated to develop them by age 50. 1 , 2 Although fibroids are not cancerous, they deleteriously affect the quality of life for millions of women. Approximately 25% of US women with uterine fibroids will experience symptoms severe enough to require treatment.…”

Section: Introductionmentioning

confidence: 99%

Uterine Fibroids: Assessing Unmet Needs from Bench to Bedside

Aninye

Laitner

2021

Journal of Women's Health

View full text Add to dashboard Cite

“…The explosive growth of a UL [ 81 , 82 , 83 ] accompanied by overexpression of multiple genes [ 84 , 85 ] may favour chromosomal rearrangements. In such cases, actively transcribed genes that are located on different chromosomes may become topologically closer to each other in the transcription factories, which, in turn, may result in faulty repair of multiple DNA breaks and the emergence of structural rearrangements [ 86 , 87 , 88 , 89 , 90 ].…”

Section: Discussionmentioning

confidence: 99%

Cytogenomic Profile of Uterine Leiomyoma: In Vivo vs. In Vitro Comparison

et al. 2021

View full text Add to dashboard Cite

We performed a comparative cytogenomic analysis of cultured and uncultured uterine leiomyoma (UL) samples. The experimental approach included karyotyping, aCGH, verification of the detected chromosomal abnormalities by metaphase and interphase FISH, MED12 mutation analysis and telomere measurement by Q-FISH. An abnormal karyotype was detected in 12 out of 32 cultured UL samples. In five karyotypically abnormal ULs, MED12 mutations were found. The chromosomal abnormalities in ULs were present mostly by complex rearrangements, including chromothripsis. In both karyotypically normal and abnormal ULs, telomeres were ~40% shorter than in the corresponding myometrium, being possibly prerequisite to chromosomal rearrangements. The uncultured samples of six karyotypically abnormal ULs were checked for the detected chromosomal abnormalities through interphase FISH with individually designed DNA probe sets. All chromosomal abnormalities detected in cultured ULs were found in corresponding uncultured samples. In all tumors, clonal spectra were present by the karyotypically abnormal cell clone/clones which coexisted with karyotypically normal ones, suggesting that chromosomal abnormalities acted as drivers, rather than triggers, of the neoplastic process. In vitro propagation did not cause any changes in the spectrum of the cell clones, but altered their ratio compared to uncultured sample. The alterations were unique for every UL. Compared to its uncultured counterpart, the frequency of chromosomally abnormal cells in the cultured sample was higher in some ULs and lower in others. To summarize, ULs are characterized by both inter- and intratumor genetic heterogeneity. Regardless of its MED12 status, a tumor may be comprised of clones with and without chromosomal abnormalities. In contrast to the clonal spectrum, which is unique and constant for each UL, the clonal frequency demonstrates up or down shifts under in vitro conditions, most probably determined by the unequal ability of cells with different genetic aberrations to exist outside the body.

show abstract

Uterine fibroid incidence and growth in an ultrasound-based, prospective study of young African Americans

Cited by 60 publications

References 27 publications

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids

Uterine Fibroids: Assessing Unmet Needs from Bench to Bedside

Cytogenomic Profile of Uterine Leiomyoma: In Vivo vs. In Vitro Comparison

Contact Info

Product

Resources

About