Uterine leiomyomas revisited with review of literature

Mathew, Rishi Philip; Francis, Swati; Jayaram, Vinayak; Anvarsadath, Shameema

doi:10.1007/s00261-021-03126-4

Cited by 15 publications

(13 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…UL, as a common disease in women, occurs in women of reproductive age ( Segars and Al-Hendy, 2017 ; Mathew et al, 2021 ). Most of the patients with UL do not affect the physical health of women, but there is a need for surgery for UL patients with fertility requirements, which cause female menorrhagia, pelvic pain, and compression symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…UL occurs in more than 70% of women before menopause, with an incidence of up to 20%–25% in women of reproductive age ( Lv et al, 2008 ; Giuliani et al, 2020 ). Accumulating clinical evidence has demonstrated that UL has caused a lot of health problems, including uterine bleeding, dysmenorrhoea, repetitive pregnancy loss, menorrhagia, infertility, pelvic pressure, and pain ( El et al, 2021 ; Mathew et al, 2021 ). Therefore, it is urgent to find new etiological and pathological features of UL to improve the diagnostic efficiency of UL ( Yuan et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An integrative analysis of an lncRNA–mRNA competing endogenous RNA network to identify functional lncRNAs in uterine leiomyomas with RNA sequencing

Meng

Chen

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

Objective: To explore the functions of mRNAs and lncRNAs in the occurrence of uterine leiomyomas (ULs) and further clarify the pathogenesis of UL by detecting the differential expression of mRNAs and lncRNAs in 10 cases of UL tissues and surrounding normal myometrial tissues by high-throughput RNA sequencing.Methods: The tissue samples of 10 patients who underwent hysterectomy for UL in Lianyungang Maternal and Child Health Hospital from January 2016 to December 2021 were collected. The differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) were identified and further analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The protein–protein interaction network (PPI) was constructed in Cytoscape software. Functional annotation of the nearby target cis‐DEmRNAs of DElncRNAs was performed with the Database for Annotation, Visualization, and Integrated Discovery (DAVID) (https://david.ncifcrf.gov/). Meanwhile, the co-expression network of DElncRNA–DEmRNA was constructed in Cytoscape software.Results: A total of 553 DElncRNAs (283 upregulated DElncRNAs and 270 downregulated DElncRNAs) and 3,293 DEmRNAs (1,632 upregulated DEmRNAs and 1,661 downregulated DEmRNAs) were obtained. GO pathway enrichment analysis revealed that several important pathways were significantly enriched in UL such as blood vessel development, regulation of ion transport, and external encapsulating structure organization. In addition, cytokine–cytokine receptor interaction, neuroactive ligand–receptor interaction, and complement and coagulation cascades were significantly enriched in KEGG pathway enrichment analysis. A total of 409 DElncRNAs–nearby-targeted DEmRNA pairs were detected, which included 118 DElncRNAs and 136 DEmRNAs. Finally, we found that the top two DElncRNAs with the most nearby DEmRNAs were BISPR and AC012531.1.Conclusion: These results suggested that 3,293 DEmRNAs and 553 DElncRNAs were differentially expressed in UL tissue and normal myometrium tissue, which might be candidate-identified therapeutic and prognostic targets for UL and be considered as offering several possible mechanisms and pathogenesis of UL in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An integrative analysis of an lncRNA–mRNA competing endogenous RNA network to identify functional lncRNAs in uterine leiomyomas with RNA sequencing

Meng

Chen

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…This new entity deserves particular attention as it may present bridging characteristics between the classic leiomyoma and its malignant version (leiomyosarcoma). In fact, STUMP in radiographic investigations usually appears as a well-circumscribed mass, with little blood circulation, which, however, due to intratumoral necrosis, can be difficult to interpret on magnetic resonance imaging [ 38 ]. In addition, histologically, the evaluation of an expert pathologist is recommended, given the different cytological forms it can take: spindle, myxoid and epithelioid STUMP.…”

Section: Discussionmentioning

confidence: 99%

An Extremely Rare Case of Disseminated Peritoneal Leiomyomatosis with a Pelvic Leiomyosarcoma and Omental Metastasis after Laparoscopic Morcellation: Systematic Review of the Literature

et al. 2022

View full text Add to dashboard Cite

Minimally invasive treatment of uterine fibroids usually requires a power morcellation, which could be associated with several complications. A rare sequela is disseminated peritoneal leiomyomatosis. Indeed, recurrence or metastasis in these cases could be attributed to iatrogenic or under-evaluation of primary tumors, although a subset of cases is a sporadic sample of biological progression. We present an extremely rare case of a patient who underwent laparoscopic morcellation and after 12 years developed a pelvic leiomyosarcoma with two omental metastases, disseminated peritoneal leiomyomatosis with a parasite leiomyoma with bizarre nuclei and a parasite cellular leiomyoma simultaneously. The diagnosis was predicted preoperatively by an expert sonographer who recognized the ultrasound characteristics of uterine sarcoma and the localization of some of the masses, so the patient was referred to the gynaecological oncologists who could appropriately treat her. We present here a case report and a systematic review that could be a useful tool for further discussion and future clinical practice guidelines.

show abstract

“…With advances in radiology, it has become easier to define the fibroid burden of weight, size, and location with a standardized reporting for gynecologists [18][19]. MIGS provides various positive outcomes for patients including decreased LOS, EBL, and complications.…”

Section: Minimally Invasive Gynecologic Surgery For Leiomyomatous Uterimentioning

confidence: 99%

The role of minimally invasive gynecologic surgeons in the era of subspecialties: when to refer and consult

Shu

Sosa

Pineda

et al. 2022

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Purpose of reviewMinimally invasive gynecologic surgery (MIGS) is a subspecialty focus of obstetrics and gynecology with focused expertise on complex benign gynecologic disorders. To date, no formal recommendations have been made in defining a referral system for MIGS. This article reviews the evidence regarding common disorders and procedures and their outcomes, and posits a basis for MIGS referral. Recent findingsIn instances where intraoperative and perioperative features may pose clinical challenges to the surgeon and ultimately the patient, the literature suggests the following scenarios may have adverse outcomes, and therefore, benefit from the skills of MIGS subspecialists: fibroids --at least five myomas, myoma size at least 9 cm, and suspected myoma weight at least 500 g; endometriosis --presence of endometrioma(s), suspected stage III/IV endometriosis, and requirement for advanced adjunct procedures; hysterectomy -uteri at least 250 g or 12 weeks estimated size, at least three prior laparotomies, obesity, and complex surgical history with suspected adhesive disease. SummaryA referral system for MIGS subspecialists has proven benefits for both the gynecologic surgical community as well as the patients and their outcomes. This article provides evidence for collaboration with MIGS especially as it relates to leiomyomatous uteri, endometriosis, and complex hysterectomies.

show abstract

Uterine leiomyomas revisited with review of literature

Cited by 15 publications

References 57 publications

An integrative analysis of an lncRNA–mRNA competing endogenous RNA network to identify functional lncRNAs in uterine leiomyomas with RNA sequencing

An integrative analysis of an lncRNA–mRNA competing endogenous RNA network to identify functional lncRNAs in uterine leiomyomas with RNA sequencing

An Extremely Rare Case of Disseminated Peritoneal Leiomyomatosis with a Pelvic Leiomyosarcoma and Omental Metastasis after Laparoscopic Morcellation: Systematic Review of the Literature

The role of minimally invasive gynecologic surgeons in the era of subspecialties: when to refer and consult

Contact Info

Product

Resources

About