Uterine sarcomas: An analysis of 69 patients

Mantravadi, Rao V.P.; Bardawil, Wadi A.; Lochman, David J.; Liebner, Edwin J.; Townsend, Darryl E.R.; Chao, Jen Hung; Chaudhuri, B. K.

doi:10.1016/0360-3016(81)90009-2

Cited by 12 publications

(2 citation statements)

References 13 publications

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“…The age distribution in this study was similar to those described previously (Salazar et al . 1978a; Vardi & Trovell 1980; Mantravadi et al . 1981).…”

Section: Resultsmentioning

confidence: 99%

Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma

Olàh

Dunn

Gee

1992

BJOG

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Objective To determine the survival data for the various tumour types of uterine sarcoma and determine the influence of various prognostic factors on survival. Design Retrospective analysis of all uterine sarcoma cases registered in the 15 year period 1967–1981. Setting West Midlands Regional Cancer Registry, serving a catchment area of 2.6 million women. Subjects 423 women registered as having a uterine sarcoma; 367 of these were associated with the two main histological types, leiomyosarcomas (LMS) and mixed mesodermal tumours (MMT). Main outcome measures Duration of survival was taken as the primary endpoint. Results The overall 5‐year survival for uterine sarcomas in this series was 31%, with the major prognostic indicator being tumour stage. Survival for mixed mesodermal tumours is similar to other sarcomas despite a tendency towards less differentiation, wider dissemination and a greater age of the patient at diagnosis. Multivariate analysis shows that for cases with similar stage, age and grade, mixed mesodermal tumours have a better prognosis than leiomyosarcomas. Conclusions These results demonstrate the danger of considering each variable in isolation when the relation between variables can lead to spurious significance or lack of significance because of the imbalances in the numbers between groups of prognostic importance. This study underlines the need for an adequate inspection of the infra‐abdominal contents at the time of hysterectomy for uterine fibroids.

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“…The age distribution in this study was similar to those described previously (Salazar et al . 1978a; Vardi & Trovell 1980; Mantravadi et al . 1981).…”

Section: Resultsmentioning

confidence: 99%

Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma

Olàh

Dunn

Gee

1992

BJOG

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“…Using autopsy data, Rose et al [13] found that bone metastases from uterine sarcomas were independent of the extent of local or intraperitoneal disease but were associated with the presence of lung metastases. Bone metastases are usually a late occurrence and are associated with widespread metastastic disease and a poor prognosis [6,9,12]. Bone metastases are usually a late occurrence and are associated with widespread metastastic disease and a poor prognosis [6,9,12].…”

Section: Discussionmentioning

confidence: 99%

Computed tomography appearance of bone metastases of leiomyosarcoma

1992

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Bone lesions in leiomyosarcoma are uncommon. When encountered, they are usually a late manifestation of disease seen in the setting of widespread systemic metastases. We present five cases of metastatic leiomyosarcoma, including one in which a bone lesion predated detection of a primary gastric leiomyosarcoma and one in which bone metastases signaled disease recurrence. Computed tomography in 14 of 16 osseous leiomyosarcomas demonstrated a lytic, non-expansile pattern.

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Chemotherapy of advanced soft‐tissue sarcomas

Antman

Elias

1988

Seminars in Surgical Oncology

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The most active single agents in soft-tissue sarcomas are doxorubicin (Adriamycin) and ifosfamide, with response rates of 20-35%. Dacarbazine (DTIC) has a response rate of 16%. A randomized trial of 5 g/m2 of ifosfamide versus 1.5 g/m2 of cyclophosphamide noted a higher response rate for ifosfamide with less myelosuppression. Both randomized studies of doxorubicin with or without DTIC documented an increased response rate for the combination. In contrast, three randomized trials of doxorubicin-based regimens with and without cyclophosphamide have failed to detect an advantage for the addition of cyclophosphamide. Thus, the most active combination for soft-tissue sarcomas is doxorubicin and DTIC. The role of the addition of ifosfamide is currently under evaluation.

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Uterine sarcomas: An analysis of 69 patients

Cited by 12 publications

References 13 publications

Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma

Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma

Computed tomography appearance of bone metastases of leiomyosarcoma

Chemotherapy of advanced soft‐tissue sarcomas

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