Despite widespread and varied nature of metastases from bronchogenic carcinoma, clinically significant gastrointestinal metastases are considered most unusual. A case is reported of a 62‐year‐old Caucasian man with an unresectable bronchogenic carcinoma (giant cell type) who developed an acute perforation of the small intestine from a metastasis following an intensive course of radiation therapy. This represents the third reported case in the literature of a bronchogenic carcinoma developing clinically significant metastatic disease to the small intestine. A possible relationship between radiation therapy and an immunologic alteration of the host tissue was discussed. While surgical exploration is mandatory in these patients, treatment should be as conservative as possible under the given circumstances.

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