Uterine Transplantation in Dogs

Abstract

An experimental surgical procedure of uterine transplantation using the omentum as a vascular supply was performed in 20 dogs. Eight of the 10 uterine autografts were considered viable. Five of the 10 dogs with homografts were treated with immunosuppressive drugs, but no significant differences in the rejection reaction between the 2 groups were noted. The described clinical behavior, laboratory studies, and gross and microscopic findings supply more information about the rejection characteristics of this organ.

Uterus human leucocyte antigen expression in the perspective of transplantation

“…From this observation, we can speculate that endothelial and endometrial cells are the most likely targets for AMR. Consistently, in experimental UTx studies, endometrial and myometrial layers differ significantly during the rejection process . During allogeneic uterus transplantation in mice, the endometrium was rejected much more rapidly than the myometrium, as evidenced by earlier lymphocyte infiltration in the endometrium.…”

“…The myometrium appeared to have the greatest resistance to rejection and retained its tissue structure for the longest time . In uterus allo‐transplantation in dogs in 1970, the graft endometrium showed total necrosis, contrary to the myometrium, where only edema and mononuclear infiltration were found two weeks after transplantation . Our results suggest that the difference between endometrium and myometrium rejection found in this pioneer study resulted from differences in HLA expression.…”

Uterine transplantation: a promising surrogate to surrogacy?

“…38 Indeed, in autotransplanted dogs and Macaque monkeys, omentopexy produced more than 70% of satisfactory revascularization of the uterus. 19,39,40 In addition, successful autotransplantation by vascular anastomosis in dogs was reported in over 80% of animals. 17,41,42 Currently used forms of vascular anastomosis are end-to-end anastomoses between the uterine, hypogastric, or inferior vena cava vessels of the graft to either of the external iliac or hypogastric vessels of the recipient.…”

Transplantation de l’utérus : expériences animales et humaines

“…É tant donné la complexité de la vascularisation pelvienne et notamment du système veineux utérin, le pouvoir de colonisation vasculaire du grand épiploon [8] a été utilisé au début comme alternative aux anastomoses vasculaires. Le grand épiploon suturé et enroulé autour du greffon a permis une vascularisation du greffon utérin satisfaisante dans 70 % des cas chez le chien [9,10] et chez le singe [11]. La méthode par omentopexie a été comparée à celle par anastomose vasculaire dans l'autotransplantation utérine chez le chien en 1973.…”

“…Les études, réalisant des tentatives d'allotransplantation par omentopexie ou anastomoses vasculaires chez le chien [10,14,16,17] ou par omentopexie chez le singe [11], ont toutes mis en évidence un rejet du greffon comme dans le cas d'allogreffes d'autres organes malgré des traitements immunosuppresseurs.…”