Utero-Placental Transfer of Octanoic, Palmitic and Linoleic Acids during Late Gestation in Gilts

Thulin, Andrew J.; Allee, G.L.; Harmon, D. L.; Davis, Duane L.

doi:10.2527/jas1989.673738x

Cited by 42 publications

(25 citation statements)

References 15 publications

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“…This is consistent with the report that modulation of dietary fatty acids of the sow milk influences the fatty-acid composition of piglets' liver and adipose tissue (Lauridsen and Jensen, 2007). In respect to manipulation of the pig diet during gestation, some authors reported that only a small amount of the dietary fatty acids can be transferred to the foetus (Thulin et al, 1989;Ramsay et al, 1991). However, a later study demonstrated that maternal dietary fat has a significant input in the fatty-acid composition of plasma and tissues in the developing foetus (Leskanich and Noble, 1999).…”

Section: -Desaturasesupporting

confidence: 91%

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

Missotten

Smet

Raes

et al. 2009

Animal

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The present study investigated whether enrichment of the pig maternal diet with n-3 polyunsaturated fatty acids (PUFA) affects the fatty-acid composition of female piglets via enhancing of expression of the lipogenic enzymes D5-desaturase (D5d) and D6-desaturase (D6d). The sows (50% Landrace 3 50% Large White) were fed a control diet or one of the experimental diets starting at day 45 in gestation. The experimental diets were supplemented either with linseed oil or fish oil, whereas the control diet contained palm oil. Expression of D5d and D6d, and fatty-acid composition was determined by Western blotting and gas-liquid chromatography, respectively, in muscle, subcutaneous adipose tissue and liver. The highest D5d protein expression was observed in the piglets' muscle, followed by subcutaneous adipose tissue, with the lowest level in the liver. Expression of D6d in the piglets' tissues followed an opposite pattern, and was highest in the liver, followed by subcutaneous adipose tissue, with the lowest level in muscle. Supplementation of the maternal diet with fish oil or linseed oil increased the level of n-3 PUFA of the piglets in a tissue-specific manner. The response of D6d and D5d protein expression in female piglets, with average birth weight 2.4 kg, to the dietary manipulation was also tissue-specific. It is suggested that the increase in n-3 PUFA content in the progeny was related, at least partially, to the activation of D6d and D5d expression.

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Section: -Desaturasesupporting

confidence: 91%

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

Missotten

Smet

Raes

et al. 2009

Animal

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“…L -1 ) and concluded that FFA are not significantly extracted by the uterus. Only trace amounts of labelled fatty acids were found in foetal plasma lipids following the injection of labelled fatty acids to anaesthetised sows [59], and some direct transfer of maternal fatty acids to the foetus was demonstrated in pigs [22,52]. In the present experiment, FFA were extracted by the uterus only when their levels were elevated.…”

Section: Glycerolmentioning

confidence: 74%

“…Measurements of blood substrate levels in pig foetuses were made either from the umbilical blood during a caesarean operation in anaesthetised animals [1,9,35,[46][47][48][49]59], or from foetuses with catheters implanted in the jugular vein or in the carotid artery [20,44,45]. An attempt of measuring substrate balances across the foetoplacental unit was also performed in the gilt [10].…”

Section: Discussionmentioning

confidence: 99%

Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

Père

2001

Reprod. Nutr. Dev.

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-Catheters were implanted in 18 gilts at 99 days of pregnancy to study the effects of meal intake on uterine and umbilical uptake of energetic substrates in the conscious pig. Blood samples were withdrawn at 105 days of pregnancy from 10 min before and up to 90 min after feeding of a 2.5-kg meal. Plasma glucose was 2.2 to 2.5 times lower and blood lactate 2 to 3 times higher in the foetus than in the sow. Glucose and lactate increased after the meal. Their umbilical uptake amounted to 0.32 and 0.26 mmol . L -1 , respectively. Fructose was found in large amounts in foetal plasma (4.3 mmol . L -1 ), but it did not seem to be metabolised by the foetus. Meal intake decreased plasma levels of FFA and glycerol in the sows, whereas they increased in the foetuses. A small FFA and glycerol umbilical uptake was recorded (14 and 6 µmol . L -1 , respectively). Most features of the maternofoetal exchanges in the porcine species resemble those of other species, especially ruminants. materno-foetal exchange / energetic substrate / meal intake / pig Résumé -Effets de la prise alimentaire sur les échanges materno-foetaux de substrats énergétiques chez le porc. Des cathéters ont été implantés sur 18 truies à 99 jours de gestation afin d'étudier chez l'animal vigile les effets d'une prise alimentaire sur la capture de substrats énergétiques par l'utérus et le foetus. Des échantillons de sang ont été prélevés à 105 jours de gestation entre 10 min avant et 90 min après la distribution d'un repas de 2,5 kg. La glycémie était 2,2 à 2,5 fois plus faible et la lactatémie 2 à 3 fois plus élevée chez le foetus que chez la mère. Elles augmentaient après le repas. La capture de glucose et de lactate par le foetus était respectivement de 0,32 et 0,26 mmol . L -1 . Les concentrations sanguines de fructose étaient élevées chez le foetus (4,3 mmol . L -1 ), mais ce substrat ne semblait pas métabolisé. La consommation du repas provoquait une diminution des teneurs plasmatiques en AGL et en glycérol des truies alors qu'elles augmentaient chez les foetus. Une faible Reprod. Nutr. Dev. 41 (2001) 285-296 285

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“…Their uptake does not represent a significant energy source for the gravid uterus of sheep [70], cows [64], mares [64] or sows [10,61]. In experiments involving ewes [71,72] or sows [73,74] injected with labelled fatty acids, only trace amounts of these fatty acids crossed the placenta during late gestation.…”

Section: Fatty Acids Ketone Bodies and Glycerolmentioning

confidence: 99%

Materno-foetal exchanges and utilisation of nutrients by the foetus: comparison between species

Père

2003

Reprod. Nutr. Dev.

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-Several general features of nutrient uptake and utilisation by foetuses are similar among mammalian species. Nevertheless, there are also differences linked mainly to differences in placental permeability. Glucose and lactate are the main energetic substrates of the foetus. In normal conditions, the oxidation of carbohydrates accounts for about 75, 60 and 50% of oxygen uptake in the foetal pig, foal and lamb, respectively, and acetate accounts for about 10% in ruminants. Acidic amino acids are synthesised by the foetus, whereas neutral and basic amino acids are transported from the placenta. As shown by the high urea level in foetal blood, amino acids are partly involved in the oxidative metabolism of foetuses; their contribution is higher in ruminants than in humans, horses and pigs. Fatty acids cross the haemochorial placenta of rodents, rabbits and primates, and are incorporated into the foetal lipids, whereas their uptake by ruminant, pig and horse foetuses is very low.materno-foetal exchange / mammal / carbohydrate / fatty acid / amino acid

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Utero-Placental Transfer of Octanoic, Palmitic and Linoleic Acids during Late Gestation in Gilts

Cited by 42 publications

References 15 publications

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

Effect of supplementation of the maternal diet with fish oil or linseed oil on fatty-acid composition and expression of Δ5- and Δ6-desaturase in tissues of female piglets

Effects of meal intake on materno-foetal exchanges of energetic substrates in the pig

Materno-foetal exchanges and utilisation of nutrients by the foetus: comparison between species

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