Uterotropic effect of ß‐HCH, a food chain contaminant

Loeber, J.G.; Velsen, F.L. van

doi:10.1080/02652038409385824

Cited by 21 publications

(6 citation statements)

References 3 publications

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“…11 ␤-BHC was also found to augment rat uterine weights in a dose-dependent fashion, 12 and a daily ␤-BHC dose of 0.5 mg/kg body weight given orally has also produced disturbances of the estrous cycle in female rats. 13 It should be noted that DDT and PCBs also possess estrogenicity and have the ability to induce cytochrome p450 mixed-function oxidase enzymes, which are intimately involved in steroid hormone metabolism.…”

mentioning

confidence: 93%

?-Benzene hexachloride in breast adipose tissue and risk of breast carcinoma

Zheng

Holford

Mayne

et al. 1999

Cancer

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mentioning

confidence: 93%

?-Benzene hexachloride in breast adipose tissue and risk of breast carcinoma

Zheng

Holford

Mayne

et al. 1999

Cancer

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“…In the UK, their levels and frequency of occurrence have been declining steadily since monitoring was carried out in 1963 (Egan et al 1965) but the risks from these compounds have been perceived as signi®cant as further research on endocrine disrupters has been published in the 1990s (Wiese and Kelce 1997). Whilst the in vivo oestrogenic activity of some organochlorines is now accepted ( -HCH (Steinmetz et al 1996, Loeber andvan Velsen 1984); DDT, its isomers and metabolites (Ahlborg et al 1995, Dees et al 1997) in comparison to other sources of oestrogenic compounds, these levels of activity are very low. Safe (1995) estimated a mass balance of human exposures 1127 Assessing risks of pesticide residues to consumers of human exposures to environmental oestrogens and anti-oestrogens (birth control pill,¯avanoids in food and environmental organochlorine s 16675, 102 and 0.0000025 mg oestrogen equivalents/day, respectively).…”

Section: Risk±bene®t Analysismentioning

confidence: 99%

Assessing the risks of pesticide residues to consumers: recent and future developments

Harris¹,

Renfrew²,

Woolridge³

2001

Food Additives and Contaminants

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Assessing exposure of consumers to pesticide residues is an area of regulatory science that has rapidly developed over the last decade. From simplistic, deterministic models calculating lifetime exposure for adults only, assessment procedures have diversified so that more realistic estimates of long term exposures for adults, schoolchildren, toddlers and infants and short term exposures for adults and toddlers (who generally bound the more extreme consumer patterns) are now carried out. The final assessment of risk still remains a simplistic numeric comparison against hazard assessment based on a wide range of toxicity studies incorporating the appropriate safety or uncertainty factors. As development of risk assessments continues, the use of probabilistic models is becoming an invaluable information tool for quantitative risk management and aiding assessment of cumulative exposure. This paper examines the recent developments in risk assessment and consumer perception of the risks of pesticide residues, and speculates where the future developments in these areas may lie.

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“…This is the first study in which blood levels of test compound were correlated to estrogenic response. In past reports xenoestrogens were administered in very large doses (100-500 mg/kg BW) and acute estrogen responses were monitored (4,(16)(17)(18)(19). The impression from such studies was that xenoestrogens, being very weakly estrogenic by a number of in vitro assays (19)(20)(21)(22), required the very large doses of compound to have an effect in vivo.…”

Section: Hi Conclusionmentioning

confidence: 99%

Novel Mechanisms of Tumor Promoter Activity by Estrogenic Xenobiotics

Bigsby¹

2000

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12b. DISTRIBUTION CODE ABSTRACT (Maximum 200 Words)Tumor promoter activity of estrogens and xenoestrogens is under investigation. Using the methylnitrosourea (MNU) treated rat, estrogens alone could not fully substitute for ovarian factors in mammary tumorigenesis. Estradiol or estrone replacement yielded 25% or 50% tumor incidence in ovariectomized rats. When progesterone was also administered alone it had no tumor promoting effect; treatment with progesterone plus estrone produced a 75% incidence. Thus, there is a synergy between progesterone and estrogen in mammary tumorigenesis.The xenoestrogen, ß-hexachlorcyclohexane (ß-HCH) did not significantly promote tumorigenesis. Only 5 of 32 ovariectomized rats treated with ß-HCH had tumors 6 months after MNU injection; this was not different from tumor incidence in the control group. Dietary restriction did not affect the rate of tumorigenesis.Both ß-HCH and another pesticide residue, o,p'-DDT induced growth of a human tumor xenograft in athymic mice. However this assay was inconsistent from between experiments and no conclusions could be drawn as to the effect of dietary restriction.Low blood levels of xenoestrogen were associated with significant increases in esgtrogenic endpoints in ovariectomized mice. Levels averaging 42 ng/ml or 18 ng/ml for ß-HCH or o,p'-DDT, respectively produced increases in vaginal epithelial proliferation and induced hypertrophy of uterine epithelium. These levels are in the same order of magnitude as human blood levels.

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Uterotropic effect of ß‐HCH, a food chain contaminant

Cited by 21 publications

References 3 publications

?-Benzene hexachloride in breast adipose tissue and risk of breast carcinoma

?-Benzene hexachloride in breast adipose tissue and risk of breast carcinoma

Assessing the risks of pesticide residues to consumers: recent and future developments

Novel Mechanisms of Tumor Promoter Activity by Estrogenic Xenobiotics

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