Uterus-Relaxation durch hochaktive Ca++-antagonistische Hemmstoffe der elektro-mechanischen Koppelung wie Isoptin (Verapamil, Iproveratril), Substanz D 600 und Segontin (Prenylamin)

Fleckenstein, A.; Grün, G; Tritthart, H. A.; Byon, K.; Harding, Pamela

doi:10.1007/bf01494064

Cited by 129 publications

(31 citation statements)

References 9 publications

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“…In order to investigate the properties of the spontaneous contractions and basal tone, we used the calcium antagonist, gallopamil, which is supposed to block the influx of Ca2+ (Fleckenstein et al, 1971). Gallopamil (10-7M) reduced the basal tone ( Figure 2) and abolished the spontaneous contractions, indicating the contribution of the influx of Ca2+ in the generation of spontaneous contraction and basal tone.…”

Section: Resultsmentioning

confidence: 99%

The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs

Ito

Suzuki

Aizawa

et al. 1989

British J Pharmacology

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1 Tissue taken at operation was used to study the electrical and mechanical properties of human bronchial smooth muscle with intracellular microelectrodes and isometric recording of tension changes. 2 Over 90% of the muscle strips exhibited spontaneous tone and 70% produced spontaneous phasic contractions. The resting membrane potential of the smooth muscle cells ranged between -40 to -50 mV with a mean value of -44.9 + 5.2 mV (n = 92 ± s.d.). Spontaneous oscillations of the membrane potential (slow waves) were observed in 90% of the cells examined. 3 The electrical slow waves, phasic contractions and spontaneous tone were greatly reduced by

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Section: Resultsmentioning

confidence: 99%

The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs

Ito

Suzuki

Aizawa

et al. 1989

British J Pharmacology

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“…Several of the inhibitory actions of these calcium antagonists, for example, gallopamil on the uterus (Fleckenstein et al, 1971;Reiner & Marshall, 1975), the papillary muscle (Warburton & Weston, 1982a) and the portal vein (Warburton & Weston, 1982b), can be reversed by increasing the Ca2" concentration of the medium.…”

Section: Discussionmentioning

confidence: 99%

“…For this reason, it is predictable that tension development in this tissue should be inhibited by calcium antagonists. Gallopamil and nicardipine inhibit mechanical activity in rat uterus (Fleckenstein et al, 1971;Reiner & Marshall, 1975;Csapo et al, 1982) while nifedipine inhibits tension development in human isolated uterus and reduces intra-uterine pressure changes in both non-pregnant and pregnant women (Forman et al, 1981). It is therefore possible that calcium antagonists could have a place in the treatment of dysmenorrhoea and of preterm labour, although the cardiovascular effects of these drugs could be a limiting factor (Nayler & Horowitz, 1983).…”

Section: Introductionmentioning

confidence: 99%

A comparison of several calcium antagonists on uterine, vascular and cardiac muscles from the rat

Granger

Hollingsworth

Weston

1985

British J Pharmacology

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1 An assessment was made of the potencies of nifedipine, gallopamil, diltiazem, cinnarizine and salbutamol as inhibitors of tension development by the uterus and cardiovascular tissues from the term pregnant rat.2 The rank order of potency was nifedipine > gallopamil > diltiazem for those preparations on which these compounds were potent, viz. spontaneous and oxytocin-induced tension development of the uterus, spontaneous tension development of hepatic portal vein, potassium chloride (KCI)-induced pressure rises of perfused mesenteric bed and electrically-stimulated (0.5 Hz) ventricular muscle. 3 The rank order of potency of nifedipine, gallopamil and diltiazem was different for those preparations on which they exhibited low potency, viz. noradrenaline-induced pressure rises of perfused mesenteric bed and tension development of aorta. 4 Gallopamil and diltiazem, but not nifedipine, were more potent against tension development by ventricular muscle stimulated at 2.5 Hz than at 0.5 Hz, suggesting that nifedipine interacts at a different site from the other compounds. 5 Cinnarizine was less potent than the other calcium antagonists on the uterus and portal vein, was the second most potent compound against KCI-induced pressure rises of the mesenteric bed and was equipotent against responses to noradrenaline and KCI of the mesenteric bed (unlike the other compounds). This suggests that the site of action of cinnarizine differs from that of the other calcium antagonists. 6 Nifedipine, gallopamil and diltiazem, like salbutamol, exhibited selectivity for inhibition of tension development by the uterus relative to the cardiovascular tissues.

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“…tOE). (Tritthart, Volkmann, Weiss & Fleckenstein, 1973) and smooth muscle (Fleckenstein, Griin, Tritthart & Byon, 1971;Golenhofen & Lammel, 1972;Mayer, van Breemen & Casteels, 1972). Fig.…”

Section: Gastric Smooth Muscle Electrical Activitymentioning

confidence: 96%

Intracellular electrical activity of canine and human gastric smooth muscle.

El-Sharkawy¹,

Morgan²,

Szurszewski³

1978

The Journal of Physiology

157

116

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SUMMARY1. Intracellular recordings were obtained from circular smooth muscle fibres of the canine fundus, corpus, antrum and pylorus as well as from the human corpus and antrum.2. In the canine stomach, all regions of the stomach except the fundus exhibited spontaneous action potentials.3. The spontaneous action potential consisted of an upstroke potential and a plateau potential.4. There were regional differences in the configuration of the plateau potential. Corporal and antral smooth muscle did not normally spike during the plateau potential whereas terminal antral and pyloric muscle usually showed spikes on top of the plateau potential. Near the intermediate sphincter, there was a zone of transition in which oscillations in potential of variable amplitude were superimposed on the plateau potential.5. The configuration of the action potential of the human stomach was similar to the configuration of the canine action potential when the same region of the stomach was compared.6. The ionic dependence of the plateau potential was studied in canine stomach in an area where neither oscillations nor spikes occurred.7. In calcium-free solution, all spontaneous activity stopped. D600 selectively suppressed the size of the plateau potential.8. Sodium-deficient solution reduced the size of the plateau potential. 9. These results suggest that both calcium and sodium may be involved as current carriers in the generation of the plateau potential.

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Uterus-Relaxation durch hochaktive Ca++-antagonistische Hemmstoffe der elektro-mechanischen Koppelung wie Isoptin (Verapamil, Iproveratril), Substanz D 600 und Segontin (Prenylamin)

Cited by 129 publications

References 9 publications

The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs

The spontaneous electrical and mechanical activity of human bronchial smooth muscle: its modulation by drugs

A comparison of several calcium antagonists on uterine, vascular and cardiac muscles from the rat

Intracellular electrical activity of canine and human gastric smooth muscle.

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