Utilidad del Cobas® Taqman® Ct Test, v2.0 para la detección de cepas de Chlamydia Trachomatis circulantes en México

López‐Hurtado, Marcela; Flores-Salazar, Verónica R.; Gutierréz‐Trujillo, Rodrígo; Escobedo-Guerra, Marcos R.; Guerra‐Infante, Fernando M.

doi:10.35839/repis.6.2.1303

Cited by 1 publication

(1 citation statement)

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“…Also, some CT variants were considered hard to detect using some NAATs, leading to false negatives. Thus, acting upon clinical suspicion, a different NAAT test, comprehending a different genomic target, should be used [56][57][58][59]. It is worth noting that it is still necessary and important to use the culture method in cases of resistance, specifically, to test the phenotype or genotype involved in antibiotic resistance mechanisms, also allowing the possible detection of new pathogen strains with mutations that cannot be detected in NAATs [66].…”

Section: Gold Standard Diagnostic Methodsmentioning

confidence: 99%

Chlamydial and Gonococcal Genital Infections: A Narrative Review

Rodrigues

Vieira‐Baptista

Catalão

et al. 2023

JPM

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Sexually transmitted infections (STIs) constitute one of the leading causes of disease burden worldwide, leading to considerable morbidity, mortality, health expenditures, and stigma. Of note are the most common bacterial STIs, chlamydial and gonococcal infections, whose etiological agents are Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), respectively. Despite being usually asymptomatic, in some cases these infections can be associated with long-term severe complications, such as pelvic inflammatory disease, chronic pelvic pain, infertility, ectopic pregnancy, and increased risk of other STIs acquisition. As the symptoms, when present, are usually similar in both infections, and in most of the cases these infections co-occur, the dual-test strategy, searching for both pathogens, should be preferred. In line with this, herein we focus on the main aspects of CT and NG infections, the clinical symptoms as well as the appropriate state-of-the-art diagnostic tests and treatment. Cost-effective strategies for controlling CT and NG infections worldwide are addressed. The treatment for both infections is based on antibiotics. However, the continuing global rise in the incidence of these infections, concomitantly with the increased risk of antibiotics resistance, leads to difficulties in their control, particularly in the case of NG infections. We also discuss the potential mechanism of tumorigenesis related to CT infections. The molecular bases of CT and NG infections are addressed, as they should provide clues for control or eradication, through the development of new drugs and/or effective vaccines against these pathogens.

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