Utilisation of s<scp>FLC</scp> assays – how well do we comply with guidelines?

Phillips, David M.; Talaulikar, Dipti; Hawkins, Carolyn; Hickman, Peter E.

doi:10.1111/ijlh.12022

Cited by 3 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[109][110][111] Exposure to gonadotropic stimulation, which produces increased physiologic levels of circulating estradiol combined with in vitro culture may be cumulatively detrimental to normal embryo growth. 112 Many emerging studies are attempting to isolate the causative factors responsible for growth disturbance in women undergoing AHR by comparing outcomes in various subsets within cohort studies of the AHR population and with outcomes in spontaneous pregnancies. Consistent with the data on the contribution of the diagnosis and causes of infertility itself, Sasanova et al performed logistic regression analysis on 8941 singleton pregnancies after IVF to determine predictive factors for preterm birth and LBW.…”

Section: Low Birth Weightmentioning

confidence: 99%

Pregnancy Outcomes After Assisted Human Reproduction

Okun

Sierra

Wilson

et al. 2014

Journal of Obstetrics and Gynaecology Canada

123

View full text Add to dashboard Cite

Section: Low Birth Weightmentioning

confidence: 99%

Pregnancy Outcomes After Assisted Human Reproduction

Okun

Sierra

Wilson

et al. 2014

Journal of Obstetrics and Gynaecology Canada

123

View full text Add to dashboard Cite

“…The role of sFLC assay in influencing clinical decisions is currently being evaluated. 7 The question this study investigates is whether sFLC assay can play a role in monitoring the reoccurrence of MM population after bone marrow transplantation. A previous study by Uljon et al 8 determined that sFLC measurements did demonstrate obvious advantages in early detection of MM reoccurrence when compared with M-spike measurements.…”

Section: Introductionmentioning

confidence: 99%

The Role of Serum Free Light Chain and M-Protein Measurements in Determining Recurrent Disease in Multiple Myeloma After Stem Cell Transplantation

Lee¹,

Zhu²,

Cornejo³

et al. 2016

ICPJL

View full text Add to dashboard Cite

The detection of reoccurrence of multiple myeloma (MM) after stem cell transplant (SCT) is usually carried out by the use of serum and urine protein electrophoresis and immunofixation. We retrospectively studied the utility of serum free light chain assay (sFLC) in a population of post-SCT MM patients and compared it to traditional methods with serum protein electrophroesis (SPEP). We compared the value of sFLC vs SPEP for predicting reoccurrence and for earlier detection. We analyzed consecutive 24MM patients diagnosed between 2004 and 2009, who underwent SCT with concomitant follow-up with sFLC and M-protein from 2004 to 2012. An elevated M-protein was indicated by a level ≥0.2g/dL. An abnormal sFLC was indicated by a κ:λ ratio >1.65 or <0.26 accompanied by an increase of >10mg/dL of sFLC from the baseline. Of the 24cases, 22 had intact immunoglobulin MM (16IgG, kappa; 2IgG lambda; 2IgA lambda; 2IgA kappa) and 2cases had light chain MM. All 24cases (100%) achieved a complete response or partial response to SCT as defined by the International Myeloma Working Group (IMWG). After SCT, 4(16.7%) MM patients remained in remission. 12(50.0%) patients had a recurrence of MM with measurable increases in both sFLC and M-spike, 5(20.8%) with increase in sFLC only and 3(12.5%) with increase in M-spike alone. Among the 20 patients with reoccurrence after SCT, 35% had earlier detection of sFLC than M-spike, 10% had M-spike detected before sFLC, 15% had concurrent elevated sFLC and M-spike, 25% had elevated sFLC only, and 15% had elevated M-spike alone. The medium time period for detecting the elevated sFLC or M-spike in patients undergoing reoccurrence after SCT was 3-6months vs. 6-9months (p-value: 0.0386; Mann-Whitney one-sided test). Our study concludes that sFLC should be used in conjunction with clinical and other traditional measures for the earliest detection of MM recurrence to ensure that the diagnosis is not missed by using SPEP assay alone.

show abstract