Utilities For Prostate Cancer Health States in Men Aged 60 and Older

Abstract

Both "watchful waiting" and treatment complications from prostate cancer treatments can have large impacts on quality of life. Mean ratings are important for use in policy-making and cost-effectiveness analyses. Variation in ratings across patients suggests that mean scores do not reflect individual preferences and that shared decision-making may be best for clinical decisions.

Association between utility and treatment among patients with prostate cancer

“…In an earlier study, Stewart et al [27] reported that bowel problem was rated as significantly more bothersome than impotence and urinary incontinence, and age was a significant predictor of higher utility ratings. In our study, we noticed most of the HRQoL subscales are associated with higher utility score, except for urinary function and sexual bother.…”

“…Additionally, QALY can be directly used in the cost-effectiveness analyses [9][10][11]. Thus, the utility scores represent the strength of an individual's preference for different health outcomes under conditions of uncertainty [24][25][26][27][28][29].…”

Stereotactic Body Radiation Therapy for Prostate Cancer: What Is the Appropriate Patient-Reported Outcome for Clinical Trial Design?

“…Which treatmentrelated symptom bears the greatest influence on post-treatment QOL? Utility analyses have shown that bowel symptoms have a greater negative impact on QOL than urinary symptoms or impotence (32). However, this may not apply for all patients, and shared decision making may be most appropriate (33).…”

Development of a Decision-Analytic Model for the Application of STR-Based Provenance Testing of Transrectal Prostate Biopsy Specimens

“…Utilities measuring the quality of life during primary androgen deprivation therapy and watchful waiting with active surveillance were also used in the construction of the model. All values for utility were taken from Stewart et al [27]. Stewart et al obtained standard gamble utilities for 19 health states from 162 subjects recruited as volunteers from the San Diego, CA, area, 52% of whom had been diagnosed with prostate cancer.…”