Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis

Hodgson, Natasha; Todd, Jeffrey M.; Schaeffer, David J.

doi:10.5326/jaaha-ms-6808

Cited by 47 publications

(83 citation statements)

References 48 publications

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“…Two recent studies investigated the NLR in SIRS and septic peritonitis in dogs. 10,11 Both studies found elevated NLRs during inflammatory processes but found no associations with the disease severity or course of disease. 10 The results of our study confirm that the NLR is increased in dogs and cats with pancreatitis compared with that of healthy controls.…”

Section: Discussionmentioning

confidence: 98%

“…In veterinary medicine, NLRs were investigated in some studies of dogs with septic peritonitis or systemic inflammatory response syndrome (SIRS). 10,11 They compared NLRs in dogs with sepsis, nonseptic systemic inflammatory disease, and controls. The conclusions about the use of the NLR as a prognostic marker in cases of severe inflammatory processes in dogs were different.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Neumann

2021

Veterinary Clinical Pathol

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Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been described as prognostic markers in cancer and inflammatory diseases. The use of these measurements in dogs and cats with acute pancreatitis has not yet been investigated. Objective: The objective was to evaluate NLR and PLR for usefulness as biomarkers for severity and clinical course of acute pancreatitis in dogs and cats. Methods: In this prospective study, we investigated 67 dogs and 41 cats with acute pancreatitis and 17 healthy dogs and cats as controls. We compared the NLR and PLR of dogs and cats with acute pancreatitis with control animals. The severity of disease was measured using a modified "bedside index of severity in acute pancreatitis" (BISAP) score in humans, and the course of the disease was measured with the time to clinical recovery. Results: NLR and PLR were significantly higher in dogs and cats with pancreatitis than in healthy controls. However, no significant relationship between NLR or PLR and disease severity was found, as assessed with the modified BISAP score. Dogs and cats with pancreatitis and prolonged recovery displayed a significantly increased PLR, and those same cats also displayed a significantly increased NLR. Conclusions: We conclude that increased NLR and PLR provide information regarding the course of pancreatitis in dogs and cats. How to cite this article: Neumann S. Neutrophil-tolymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Neumann

2021

Veterinary Clinical Pathol

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“…These Sepsis-3 definitions incorporate a rapid organ failure assessment score (92), that has yet to be robustly examined in veterinary medicine. An equivalent redefinition of sepsis in veterinary medicine had not been undertaken and hence the SIRS criteria remain the best available strategy (93), and have been used in multiple studies of canine sepsis and of septic peritonitis specifically (6, 14, 94, 95). As such, they were considered to be a necessary component of the identification of the SP and NSA populations in the present study.…”

Section: Discussionmentioning

confidence: 99%

Biomarker Guided Diagnosis of Septic Peritonitis in Dogs

Martiny

Goggs

2019

Front. Vet. Sci.

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Septic peritonitis (SP) is common in dogs and is associated with high mortality. Early recognition is essential to maximizing survival and may be aided by biomarker measurement. The present study aimed to evaluate the ability of biomarkers to discriminate septic peritonitis from non-septic ascites (NSA). Eighteen dogs with SP and 19 age-matched controls with NSA were enrolled. Contemporaneous blood and peritoneal effusion samples were obtained. Concentrations of cell-free DNA (cfDNA), cytokines, glucose, lactate, N-terminal pro-C-type natriuretic peptide (NT-proCNP), nucleosomes, and procalcitonin (PCT) were measured using commercial reagents and assays. Paired biomarker concentrations were compared with the Wilcoxon matched-pairs signed rank test, and biomarker concentrations between groups were compared with the Mann-Whitney U -test. P -values were adjusted for multiple comparisons using the Bonferroni correction. Receiver operating characteristic curves were generated to assess the ability of the above biomarkers to discriminate SP from NSA. Dogs with SP had significantly greater blood CCL2 concentrations than dogs with NSA ( P = 0.032). Dogs with SP had significantly greater effusion CCL2, IL-6, IL-10, and lactate concentrations than dogs with NSA ( P ≤ 0.0121). Blood-effusion concentration gradients of CCL2, glucose, IL-6, IL-10, and lactate were significantly different in dogs with SP compared to dogs with NSA ( P ≤ 0.0165). Effusion lactate concentration had the highest AUROC value (0.866, 95% CI 0.751–0.980, P = 0.0001), although other biomarkers performed similarly. An effusion lactate concentration of 4.2 mmol/L was 72.2% (95% CI 46.5–90.3%) sensitive and 84.2% (95% CI 60.4–96.6%) specific for the diagnosis of SP.

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“…Likewise, humans affected by OSA also demonstrate higher N/L ratio, positively correlated to the OSA severity 48 and mitigated by continuous positive airway pressure (CPAP) therapy 48 , 49 . Furthermore, high N/L ratios were reported in dogs affected by systemic inflammatory response syndrome 50 and septic peritonitis 51 , but not yet described in brachycephalic dogs. Therefore, we considered the existence of a subacute inflammatory status on brachycephalic dogs, which corroborates previously evidence that this syndrome leads to systemic inflammatory derangements 10 , 52 , and probably to consequences such as observed in humans with OSA.…”

Section: Discussionmentioning

confidence: 93%

Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers

Facin

Uscátegui

Maronezi

et al. 2020

Sci Rep

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The purpose of this study is to determine whether the brachycephalic obstructive airway syndrome (BOAS) is correlated to alterations in liver and spleen elasticity. Forty-eight brachycephalic and 22 mesocephalic dogs were submitted to a BOAS functional assessment, laboratory tests, abdominal ultrasound and liver and spleen Acoustic Radiation Force Impulse (ARFI) elastography. Dogs clinically affected by BOAS had higher values of liver stiffness (p < 0.001) than healthy dogs: medial lobes (1.57 ± 0.37 m/s), left and right lateral lobes (1.54 ± 0.50 m/s, 1.23 ± 0.28 m/s, respectively) and caudate lobe (1.28 ± 0.42 m/s). Compared to the mesocephalic group, the brachycephalic group (BOAS clinically affected and unaffected dogs) had higher spleen (2.51 ± 0.45 m/s; p < 0.001) and liver stiffness (p < 0.001): medial lobes (1.53 ± 0.37 m/s), left and right lateral lobes (1.47 ± 0.47 m/s, 1.20 ± 0.30 m/s, respectively) and caudate lobe (1.23 ± 0.40 m/s). Principal component analysis explained 70% of the variances composed by liver stiffness increase, erythrocytes and alanine aminotransferase reduction. Brachycephalic dogs had higher spleen and liver stiffness and a subacute inflammatory state, which represent another BOAS systemic effect. Consequently, these dogs can be at higher risk of hepatic disorders compared with mesocephalic dogs, similarly to humans affected by sleep apnea syndrome.

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Utility and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Dogs with Septic Peritonitis

Cited by 47 publications

References 48 publications

Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios in dogs and cats with acute pancreatitis

Biomarker Guided Diagnosis of Septic Peritonitis in Dogs

Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers

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