Utility of a fluorescent probing strategy for designing a distinctive chemically mutagenized reaction for the determination of an antiepileptic agent; topiramate

Hamad, Ahmed Abdulhafez

doi:10.1016/j.talo.2022.100179

Cited by 15 publications

(4 citation statements)

References 34 publications

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“…[ 42 ] This is because the procedure we created used methanol as a solvent, and no extraction, heating, or energy‐consuming processes were used per sample (less than 0.1 kW h). Using the eco‐scale, our designed approach scored 92, which indicated that our method was environmentally friendly [ 43 ] (Table 7).…”

Section: Resultsmentioning

confidence: 99%

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

et al. 2023

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Mitoxantrone (MXN) is a synthetic anthracenedione oncogenic therapy. It is often prescribed as an anticancer agent to manage a variety of cancers. A green, fast, and easy fluorimetric technique for the assay of MXN as a topoisomerase type II enzyme suppressor. An investigation of MXN's fluorescence behavior in various media and solvents constituted the basis for this new technique. Methanol was shown to enhance the intrinsic fluorescence considerably. After excitation at 610 nm, the highest fluorescence intensity was found at 675 nm. Various experimental parameters, such as media, solvents, and pH levels, were tested and adjusted. ICH (International Conference on Harmonization) guidelines were followed when validating procedures. It was possible to achieve linearity in the 0.02–1.50 μg ml−1 with the method. The sensitivity (in terms of limit of detection and limit of quantification) was 0.003 and 0.008 μg ml−1, indicating low toxicity. As a result, the current technology has a remarkable recovery for detecting residues in diverse bodily fluids. Also, the quantum yield was estimated for the designed system. Finally, the method was rated by eco‐scale scoring.

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Section: Resultsmentioning

confidence: 99%

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

et al. 2023

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“…The method employed for the calculation of the emission quantum value of the resulting system was the comparable one. The blank (reference fluorescent material) solution, comprising fluorescein, exhibits a value of 0.79 [61]. The quantum result of the examined samples was determined by utilizing the regression line's slope, which was achieved by plotting the absorbance against the fluorescence peak area for each measurement.…”

Section: Resultsmentioning

confidence: 99%

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Alqarni,

Haredy,

Abdelrahman

et al. 2024

Luminescence

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The suggested study adheres to a particular protocol to ensure that the process is environmentally friendly and sustainable. It is worth mentioning that several tools have been adopted as prospective measures of the method greenness. Fortunately, the established analytical method is identified as white by the white analytical chemistry (WAC) concept, which uses the red/ green/blue color scheme (RGB 12 tool) to combine ecological and functional factors for the first time in studying of the cited drug. Amlodipine (AMD), a cardiovascular treating agent, belongs to the dihydropyridine class of oral calcium channel‐blocking agents. This article presents a novel, simple, green, one‐pot‐processed, fast, and ultrasensitive fluorimetric approach for monitoring and assessment of AMD using molecular‐size‐dependent fluorescence augmentation of the light scattering‐driven signal of eosin, a biological stain at a wavelength of 415 nm. This enhancement was directly proportional to the size of the produced complex. The linearity range was from 30 to 900 ng mL−1, with corresponding sensitivity limits (detection and quantitation levels) of 9.2 and 28 ng mL−1, respectively. The planned approach was also successfully used to track AMD content in bulk, dosage forms, and bio‐fluids (human plasma and urine). The developed method's eco‐friendliness was established by different eco‐rating metric tools.

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“…The higher the rate (number), the more green the analysis is. 57–59 Energy consumption per sample was less than 0.1 kWh because no extraction or heating was required. Using an aqueous medium for all of the procedure's steps 60 contributed to the procedure's high eco-scale score of 95 (ESI Table 8†).…”

Section: Methods Vetting and Validationmentioning

confidence: 99%

Facile utility of felumin, a biological dye for the first fluorimetric determination of l-tetramisole drug through an “on–off fluorescence” strategy

Hamad

2023

RSC Adv.

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Utility of a fluorescent probing strategy for designing a distinctive chemically mutagenized reaction for the determination of an antiepileptic agent; topiramate

Cited by 15 publications

References 34 publications

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

An eco‐friendly matrix‐augmented fluorescence spectroscopic approach for the analysis of mitoxantrone, an oncogenic therapy; application to the dosage form and biological matrices

Application of a white and green spectrofluorimetric approach for facile quantification of amlodipine, a hypotensive drug, in batch materials, dosage forms, and biological fluids; content homogeneity testing

Facile utility of felumin, a biological dye for the first fluorimetric determination of l-tetramisole drug through an “on–off fluorescence” strategy

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