Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin

McDaniel, Katherine L.; Moser, Virginia C.

doi:10.1016/0892-0362(93)90065-v

Cited by 165 publications

(164 citation statements)

References 23 publications

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“…Therefore, activity in the elevated plus maze, social interaction, rectal temperature, and neurotransmitter levels were evaluated 120 min after treat- by exposure to different types of pyrethroids, including DTM 3,15,26,27,28,29 . Interestingly, the decreased locomotor and rearing frequencies were followed by an increased duration of immobility.…”

Section: Discussionmentioning

confidence: 99%

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Ricci

Ferreira

Habr

et al. 2013

Braz. J. Vet. Res. Anim. Sci.

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Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission.Keywords: Deltamethrin. Pyrethroid. Anxiety. Behavior. Central neurotransmitters. ResumoInseticidas piretróides são amplamente utilizados para controle de pragas, como na prevenção de pulgas em animais de estimação e sprays de plantas para a casa e na agricultura. Deltametrina (DTM) é um inseticida piretróide tipo II usado para controlar uma variedade de insetos na agricultura e ambientes domésticos. O presente estudo investigou os possíveis efeitos ansiogênicos de DTM (1, 3 e 10 mg/kg) em ratos, utilizando métodos comportamentais e neuroquímicos. Foi avaliada a atividade locomotora geral e comportamento no labirinto em cruz elevado e teste de campo aberto. Os níveis de neurotransmissores e metabólitos no estriado e hipocampo também foram mensurados. DTM (i) reduziu a locomoção e a frequência de levantar, (ii) aumentou da duração da imobilidade, (iii) reduziu o tempo de interacção social, (iv) reduziu a percentagem de entradas e tempo gasto nos braços abertos do elevado labirinto em cruz, (v) reduziu o número de cruzamentos no centro do labirinto em cruz elevado, (vi) aumentou neurotransmissor serotonina e de seu metabólito estriatal, e (vii) não alterou a coordenação motora no rotarod, duração do grooming no teste de campo aberto, temperatu...

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Section: Discussionmentioning

confidence: 99%

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Ricci

Ferreira

Habr

et al. 2013

Braz. J. Vet. Res. Anim. Sci.

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“…Abnormal motor functions, decreased grip strength and reflex changes were also observed in rats after a single gavage dose of �60 mg/kg cypermethrin or �75 mg/kg permethrin (McDaniel & Moser, 1993). Some neurobehavioural parameters, but not all, were affected in rats by a single oral (not specified) dose of 10 mg fenvalerate/kg, approximately 1/10 of a dose required for convulsions to occur (Moniz et al, 1994).…”

Section: Adult Animalsmentioning

confidence: 99%

“…Most of them have been carried out at relatively high exposure levels (McDaniel & Moser 1993;Moniz et al, 1994;Husain et al, 1996) and, while demonstrating adverse effects, do not significantly contribute to the risk assessment. However, in two studies relatively low exposure levels were used (De Souza Spinoza et al, 1999;Righi & Palermo-Neto, 2003).…”

Section: Adult Animalsmentioning

confidence: 99%

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Siegert¹,

Walker²,

Miller³

2009

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“…Su efecto tóxico se manifiesta principalmente sobre la excitación del sistema nervioso central (SNC) y del sistema nervioso perifé-rico (Verschoyle & Aldrige, 1980;Krechniak & LobodaPeplinska, 1991;McDaniel & Moser, 1993;Crofton et al, 1995), siendo causa de intoxicaciones laborales agudas en exposiciones de corto tiempo (Chen et al, 1991), o afectando el nivel de conciencia frente a exposiciones prolongadas (He et al, 1989).…”

Section: Introductionunclassified

Efecto de Dosis Única Intraperitoneal de Cipermetrina en la Corteza Cerebral Somatosensorial de Ratones CF- 1

et al. 2008

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RESUMEN:La cipermetrina es un pesticida ampliamente utilizado en agricultura y en salud pública. Sus efectos histopatológicos a nivel de sistema nervioso central han sido poco estudiados, aún cuando se han demostrado casos de intoxicación en humanos, con importante compromiso neurológico. El propósito de este trabajo es conocer los efectos de una dosis única intraperitoneal de cipermetrina sobre la morfología neuronal de corteza somatosensorial (láminas superficiales y profundas) de ratones CF-1. 35 ratones fueron separados en tres grupos: control (n=5), control vehículo (n=15) y experimental (n=15); los dos últimos grupos sacrificados los días 1, 8, 18, 26 y 35, en grupos de a tres. Los encéfalos fueron removidos, fijados, y procesados con técnica de rutina, para un análisis morfométrico. Análisis estadístico con Kruskal Walli's test. Fueron evidenciadas alteraciones morfológicas correspondientes a muerte neuronal en todas las láminas estudiadas, a los distintos intervalos de tiempo.

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Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin

Cited by 165 publications

References 23 publications

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos

Differential Behavioral Responses of <I>Anopheles gambiae</I> (Diptera: Culicidae) Modulate Mortality Caused by Pyrethroid-Treated Bednets

Efecto de Dosis Única Intraperitoneal de Cipermetrina en la Corteza Cerebral Somatosensorial de Ratones CF- 1

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