Utility of cysticercus fasciolaris antigen in Dot ELISA for the diagnosis of neurocysticercosis

ELISA in the evaluation of therapeutic response to albendazole in neurocysticercosis

“…20e22 We used, for the first time, larval antigens of T. taeniaeformis antigen in ELISA for the detection of antibodies to cysticercus with a sensitivity of 93.54% and a specificity of 84.2%. 7 In immunoblot assays we a found marked antigenic similarity between C. cellulosae and C. fasciolaris (unpublished data). Besides the diagnostic dilemmas, treatment protocols for NC are also riddled with controversies regarding the efficacy of anti-helminthics in the radiological cure and long-term seizure control in neurocysticercosis.…”

“…The crude membrane extract was prepared from mature cysticerci developing in rat liver, 60 days after infestation of male Duchrey rats with ova of T. taeniaeformis. 7 The membrane extract was prepared by dissecting membranes from scolices and adherent liver tissue on ice followed by sonication and centrifugation at 4 C for 30 min. The supernatant adjusted to a concentration of 150 mg/dl was used as the antigen concentrate.…”

“…4e6 We have for the first time used membrane antigen of C. fasciolaris (the rat pathogen) in anti-IgG and anti-IgM ELISA for the immunodiagnosis of NC. 7 While immunoassays have been frequently evaluated and are established in current clinical use as diagnostic procedures, only few studies with limited subjects are available on the evaluation of ELISA and EITB assays in the estimation of therapeutic response in NC. 8e10 Currently, response to therapy is monitored in clinical practice by repeat CT scans or magnetic resonance (MR) imaging of the brain.…”

Synthesis of 5-arylazothiazoles, pyridines and thieno[2,3-b]pyridines derivatives containing 1,2,3-triazole moiety

“…Some of these compounds have also anti-inflammatory, antidiabetic, anaesthetic and analgesic properties [7][8][9]. In addition, pyrazolines have played a crucial part in the development of theory in heterocyclic chemistry and also been used extensively in organic synthesis [10][11][12][13][14].…”

Synthesis and Anticancer and Antiviral Activities of New 2‐Pyrazoline‐Substituted 4‐Thiazolidinones

“…The antiviral research of 4‐thiazolidinones and pyrazolines also received considerable attention. Among antecedent derivatives, some novel compounds have been identified to be active against vaccinia virus ( VI ) with EC 50 of 7.0 μg/mL [18] and tabacco mosaic virus ( VII ) [19]. Compound VII showed promising anti‐HIV activity in vitro against IIIB (IC 50 = 5.7 μ M ) and ROD strains (IC 50 = 7.0 μ M ) [20].…”