Utility of EBUS-TBNA in diagnosing mediastinal tuberculous lymphadenitis in East London

Lucey, Olivia; Potter, Jessica; Ricketts, William; Castle, Lianne; Melzer, Mark

doi:10.1016/j.jinf.2021.10.015

Cited by 8 publications

(15 citation statements)

References 19 publications

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“…The sensitivity and specificity findings of EBUS-TBNA in the evaluation of suspected patients with INTBLA are variable, but has been found to be very high in some settings. [12][13][14][15]24,25 In the present study, EBUS-TBNA had a sensitivity of 83.9% for the detection of INTBLA. Lucey et al 15 who explored the utility of EBUS-TBNA among a cohort of individuals with intrathoracic lymphadenopathy of unclear etiology revealed that amongst the subgroup of subjects having TB, EBUS-TBNA had a sensitivity of 59.3% and a specificity of 100%.…”

supporting

confidence: 51%

“…[12][13][14][15]24,25 In the present study, EBUS-TBNA had a sensitivity of 83.9% for the detection of INTBLA. Lucey et al 15 who explored the utility of EBUS-TBNA among a cohort of individuals with intrathoracic lymphadenopathy of unclear etiology revealed that amongst the subgroup of subjects having TB, EBUS-TBNA had a sensitivity of 59.3% and a specificity of 100%. In a study of 527 individuals with pulmonary conditions and mediastinal lymphadenopathy in Turkey, the sensitivity and specificity of EBUS-TBNA for detecting INTBLA was 87.5% and 98.5%, respectively.…”

supporting

confidence: 51%

“…[10][11] Some studies have assessed the importance of EBUS-TBNA during the evaluation of individuals having suspected INTBLA and reported sensitivity rates of 59.3 to 94.0%. [12][13][14][15] There is no data on the usefulness of EBUS-TBNA in the assessment of suspected INTBLA in Saudi Arabia whereas TB burden is relatively low. 1 Therefore, the aim of this study was to describe the diagnostic utility of EBUS-TBNA in the assessment of suspected cases of INTBLA in a setting with a lowermoderate burden of TB.…”

mentioning

confidence: 99%

“…17 Also, several studies have demonstrated the safety and efficacy of EBUS-TBNA for INTBLA and other mediastinal masses diagnosis. [12][13][14][15] The differences in the diagnostic accuracy reported for EBUS-TBNA during the evaluation of individuals with INTBLA may be due to differences in the burden of TB in the setting where the study was carried out. For example, in Saudi Arabia, there is a lower-moderate burden of TB with TB incidence rate of 20.2/100,000 population in Makkah region, while the setting of the present study (Jeddah) had a rate of 25.4/100,000 population.…”

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confidence: 99%

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Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Aljohaney

2023

SMJ

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Objectives: To assess the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for presumptive tuberculosis (TB) patients with intrathoracic enlarged lymph nodes in a country with low to moderate TB incidence.Methods: Thirty-one patients with clinical features of TB and intrathoracic lymphadenopathy, who had EBUS-TBNA sampling and final confirmation of intrathoracic TB lymphadenopathy, were retrospectively reviewed over an 8-year period. Routine clinical Original Articleand laboratory evaluations including computerized tomography scans were performed before the EBUS-TBNA. Sociodemographic characteristics, clinical profile, pathological, and microbiological findings were collected. Results:The EBUS-TBNA confirmed TB diagnosis in 26 (83.9%) subjects with a consistent pathological finding or positive culture of Mycobacterium tuberculosis. Pathological analysis had findings consistent with TB in 25 (80.6%) patients. Culture of the EBUS-TBNA sample was positive for Mycobacterium tuberculosis in 12 (38.7%) patients. Other supportive investigations like purified protein derivative (PPD) skin test was positive in 28 (90.3%) participants. Overall, the sensitivity of the EBUS-TBNA alone was 83.9%. No complications were recorded during the procedure. The EBUS-TBNA aspirate culture positivity was significantly related to having a larger size lymph node (p=0.048) only, while PPD positivity was significantly related to baseline and clinical features of the participants. Conclusion:The EBUS-TBNA demonstrated effective utility and safety in the evaluation and diagnosis of intrathoracic TB lymphadenopathy among individuals with compatible symptoms in a country with lowmoderate TB-incidence.

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confidence: 51%

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confidence: 51%

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confidence: 99%

mentioning

confidence: 99%

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Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Aljohaney

2023

SMJ

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“…Mycobacterial infection accounted for the highest proportion of the infection diseases; Most of these patients have unexplained mediastinal lymphadenopathy, which is easily confused with tumor and needs to be clearly identi ed. Recent literature also reported that EBUS-TBNA has a good diagnostic value for mediastinal tuberculosis [16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

Clinical application of endoscopic ultrasonography-guided transbronchial needle aspiration biopsy ---A single center, large sample, real-world study

Tang¹,

Zhu²,

Zhong³

et al. 2022

Preprint

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Background Endoscopic ultrasonography-guided transbronchial needle aspiration biopsy (EBUS-TBNA) has been used for more than 10 years in China. Its clinical application and diagnostic value in different diseases with large sample was lack of report. Methods A retrospective analysis was performed about the application and diagnostic value of EBUS-TBNA in different disease of patients in Respiratory Intervention Center of Guangzhou Institute of Respiratory Health from January 2012 to July 2020. Results A total 5758 patients were included with 182 patients excluded for lack of information. Finally, data of 5576 patients (3798 males and 1778 females) were analyzed. For anesthetize, most patients were undergoing general anesthesia of intravenous with spontaneous breathing (69.4%), followed by general anesthesia of intravenous and inhalation with tracheal intubation and mechanical ventilation (17.9%) and conscious sedation and analgesia (12.8%). Lymph nodes were the main sites of biopsy obtained (76.4%). Tumors accounted for the highest proportion of disease (66.4%), followed by infection diseases (9.9%), sarcoidosis (3.9%), lymphoma (1.1%), and others (18.7%). The sensitivity of EBUS-TBNA for diagnosis of tumor was 89.7% and 40.8% for infection diseases. There were significant differences in the puncture site and proportions of diseases between male and females (both p < 0.05). Higher diagnostic value was found in male patients (p < 0.05). Conclusion EBUS-TBNA has good diagnostic value for different mediastinal and central pulmonary space-occupying lesions diseases, with highest sensitivity for tumors. Higher diagnostic value was found in male patients.

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Advances in mRNA vaccine research in the field of quality control

Huang,

Li,

Dong

2024

Biologicals

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Utility of EBUS-TBNA in diagnosing mediastinal tuberculous lymphadenitis in East London

Cited by 8 publications

References 19 publications

Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Real time endobronchial ultrasound transbronchial needle aspiration for the diagnosis of tuberculous intrathoracic lymphadenopathy

Clinical application of endoscopic ultrasonography-guided transbronchial needle aspiration biopsy ---A single center, large sample, real-world study

Advances in mRNA vaccine research in the field of quality control

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