Utility of Glycated Hemoglobin in Diagnosing Type 2 Diabetes Mellitus: A Community-Based Study

Abstract

A HbA1c cut point of 6.1% has an optimal sensitivity and specificity of 81% and can be used as a screening test, and a cut point of 6.5% has optimal specificity of 88% for diagnosis of diabetes.

2. Classification and Diagnosis of Diabetes

“…Race/Ethnicity A1C levels may vary with patients' race/ ethnicity (6,7). For example, African Americans may have higher A1C levels than non-Hispanic whites despite similar fasting and postglucose load glucose levels.…”

Antihyperglycemic and antihyperlipidemic activity of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism

“…Blood samples were collected by clipping the tail vein for the measurement of blood glucose, from 0 (before administration) to 6 h at an interval of 1 h after the treatment. Blood glucose was measured by glucose oxidase method [10] , and the results were compared with normal control and diabetic control groups. The fraction with maximum antihyperglycemic activity was selected as the active fraction.…”

Impaired Glucose Tolerance, Obesity and Inflammatory Mediators

“…In addition hemoglobin A1C (HbA1C) measurement has also become the focus of considerable attention for diagnosis of diabetes. HbA1C is formed by the nonenzymatic attachment of glucose to the N-terminal valin of the beta chain of hemoglobin and its normal range is between 4% and 6% [2][3][4]. Because of the long life span of erythrocytes, HbA1C reflects long-term glycemic exposure, representing the average glucose concentration over the preceding 8-12 weeks [2].…”