Utility of High‐Resolution Mass Spectrometry for New Drug Discovery Applications

Thin layer chromatography‐autography‐high resolution mass spectrometry analysis: accelerating the identification of acetylcholinesterase inhibitors

“…Once an AChE inhibitor is located on the TLC sheet the isolation process begins, guided by analytic and spectroscopic tools to elucidate the structure responsible for the detected activity. Of the numerous types of analytical techniques used in many phases of drug discovery, mass spectrometry (MS) has become irreplaceable because of its high sensitivity, speed, selectivity, versatility, and ease of automation (Bart Emary and Zhang, ). High resolution mass spectrometry (HRMS) has become, with the advent of “omics” sciences, something more than a tool for accurate molecular weights.…”