Utility of in situ sodium alginate/karaya gum gels to facilitate gastric retention in rodents

Foster, Kimberly A.; Morgen, Mike; Murri, Brice; Yates, I.C.; Fancher, R. Marcus; Ehrmann, Jon; Gudmundsson, Olafur; Hageman, Michael J.

doi:10.1016/j.ijpharm.2012.06.009

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…As a gastric filler, the materials are required to be strong enough to withstand gastric pressure, stay in the stomach for an appropriate time, and be ingestible or biodegradable without causing intestinal obstruction . Bearing this in mind, we will design and construct a GelMA cross‐linked PVDT hydrogel (PVDT‐GelMA) and investigate its feasibility as a gastric filler in this proof of concept study.…”

Section: Introductionmentioning

confidence: 99%

A pH‐Responsive Biodegradable High‐Strength Hydrogel as Potential Gastric Resident Filler

Zhang

et al. 2018

Macro Materials & Eng

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In this study, a pH‐responsive biodegradable high‐strength hydrogel [poly(2‐vinyl‐4,6‐diamino‐1,3,5‐triazine) (PVDT)‐methacrylated gelatin (GelMA)] is synthesized by copolymerization of hydrogen bonding monomer 2‐vinyl‐4,6‐diamino‐1,3,5‐triazine (VDT) and GelMA. The PVDT‐GelMA hydrogel exhibits up to 1.87 MPa tensile stress, 420% breaking strain, 7.24 MPa Young's modulus, and 13.9 MPa compressive strength at 80% strain at pH 7.4, and declines sharply in mechanical performance at pH 1.2 due to the breakup of hydrogen bonding. The strength that the PVDT‐GelMA hydrogel maintains in an acid medium is still superior to that of gastric pressure. This hydrogel can be completely degraded in simulated gastric fluid owing to the synergistic effect of acid swelling and enzymolysis. In a rabbit model experiment, the PVDT‐GelMA hydrogel can reside in the stomach for about 48 h, and no in vivo toxicity is detected in its metabolites, showing an appealing potential as a gastric filler or depot for bariatric interventions and drug delivery.

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Section: Introductionmentioning

confidence: 99%

A pH‐Responsive Biodegradable High‐Strength Hydrogel as Potential Gastric Resident Filler

Zhang

et al. 2018

Macro Materials & Eng

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“…The response surface plots showed that various combinations of independent variables HPMC K100M and sodium alginate may satisfy any specific requirement (i.e. max drug release up to 12 h) while taking into consideration various factors involved in dosage form [30].…”

Section: Resultsmentioning

confidence: 99%

Investigation and Optimization of the Effect of Polymers on Drug Release of Norfloxacin from Floating Tablets

2017

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Oral delivery of drugs is by far the preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation, etc [1]. The majority of formulations available on the market are oral drug delivery systems. Oral drug delivery systems have developed from immediate release to targeted or site specific delivery over a predefined period. An ideal drug delivery system possess two important characteristics that are with single dose frequency and ability to release the active drug directly at the site of action [2]. Thus, the objective of the pharmacist is to develop systems that release an optimal quantity of drug to a desired site of action. Attempts to develop a single-dose therapy for the whole duration of treatment has lead to the development of controlled or sustained release drug delivery systems.Oral controlled release systems have been developed to achieve optimal drug delivery to the systemic circulation. Although such systems can precisely control the drug release for a prolonged period of time, even over a number of days, some drugs have a narrow absorption window due to them not being absorbed through the gastrointestinal tract, as the dosage formulation will pass through the absorption window. Thus, there was the need to develop a formulation which will prolong the gastric residence time of the system to achieve complete drug release in the gastrointestinal tract (stomach and small intestine) and which will modulate the drug release rate as predicted by the system.Norfloxacin is amongst the most prescribed fluoroquinolone antiinfective for urinary tract infections, prostatitis, gonorrhea and genital tract infection Objectives. The objective of this study was to investigate the effect of release-retarding polymers on the drug release of norfloxacin from floating tablets. Material and Methods. Norfloxacin was procured as a gift sample from Concept Pharma Ltd. Aurangabad (India) and HPMC K100M was procured as a gift sample from Colorcon Asia Pvt. Ltd., Goa (India). The tablets were prepared by direct compression method and various pharmaceutical parameters were evaluated. Results. It was observed that all tablet formulations F1-F9 retained the drug release up to 12 h with good floating property but only Batch-F4 complies with the USP dissolution limits with a minimum floating lag time. The drug release kinetics were evaluated by the model-dependent (curve fitting) method using PCP Disso v3 software shows Batch-F4 shows to best fit with Peppas model for which R2 value was 0.9921 and the release exponent value was 0.6892. Conclusions. The drug release kinetics study indicates that the floating tablets release the drug by diffusion followed by erosion mechanism. Obtained in-vitro drug release data was analyzed by design expert software for drug release at first hour and at 12 th h values and found that release the selected independent variables like HPMC K100M and sodium alginate concentration has a significant effect on drug release (Polim. Med. 2016, 46, 2, 117-127).

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“…This limitation was obvious in methods of preparation such as that by Youssef et al (2015), where alginate needed to be mixed with water heated to 90 • C to obtain a clear sodium alginate liquid and then cooled to 40 • C to add calcium carbonate (Youssef et al, 2015). Additionally, Foster et al used this desirable mixture by using a high-shear mixer at 12,000 rpm and then cast this mixture on liquid (Foster, 2012). Farrés increased the temperature to 90 • C during preparation to develop a homogenous sodium alginate mix-ture before adding calcium carbonate (Farrés and Norton, 2014).…”

Section: Introductionmentioning

confidence: 99%

Oily in situ gels as an alternative floating platform for ketoconazole release

Mohamed

Jaafar

Sabar

et al. 2020

ijrps

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Sodium alginate, calcium carbonate, and guar gum were mixed with oils such as olive oil (OO), sesame oil (SO), and medium chain triglyceride (MCT). The oily formulations were found to simplify the preparation of in situ floating gel. This was the aim of this study using ketoconazole (keto) as a model drug. The investigations for the floating property were established by In vitro gelling capacity study and In vitro floating study. Additionally, in vitro release study was applied to find the best formulations to delay the release of keto. Then, selected formulations were studied by FTIR and SEM. Lastly, in vivo gelation was performed to examine the gelation in the rat’s stomach. The results showed all formulations were floating after successful gelation as the least amount of sodium alginate to gel oils was 20% w/w. The gels in SO and OO were better than MCT in delaying keto release, and 30% w/w sodium alginate in SO was the best to delay the release of keto within 8 hours of the release study. Selected gels showed interactions between the keto molecules and the molecules of the gel contents by FTIR study, and SEM showed a difference in the internal structure of selected formulations. Lastly, the 30% w/w sodium alginate in SO proved to gel and remain in the rat's stomach in the following periods: 30 min, 1 hour, 2 hours, and after 8 hours. Oily suspension formulations showed floating properties in the stomach and slowed the release of keto and specifically 30% w/w of sodium alginate in SO.

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Utility of in situ sodium alginate/karaya gum gels to facilitate gastric retention in rodents

Cited by 13 publications

References 19 publications

A pH‐Responsive Biodegradable High‐Strength Hydrogel as Potential Gastric Resident Filler

A pH‐Responsive Biodegradable High‐Strength Hydrogel as Potential Gastric Resident Filler

Investigation and Optimization of the Effect of Polymers on Drug Release of Norfloxacin from Floating Tablets

Oily in situ gels as an alternative floating platform for ketoconazole release

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