Utility of Indium-111 Octreotide to Identify a Cardiac Metastasis of a Carcinoid Neoplasm

Farooqui, Mohammed; Rathore, Sulaiman; Ball, Timothy R.

doi:10.1080/08998280.2016.11929369

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…The tracer, a somatostatin analogue, binds the somatostatin receptors on the carcinoid tumor that is affecting the heart (of note, the tracer is not useful in the presence of nonmetastatic carcinoid HD). 18 F-dihydroxyphenylalanine, gallium-68 octreotide, and indium-111 octreotide have been used as tracers, [72][73][74][75] but new ones such as iobenguane I-123 might have better sensitivity and specificity for neuroendocrine tumors in general and necessitate less radiation. 76…”

Section: Carcinoid Heart Diseasementioning

confidence: 99%

Carcinoid Heart Disease: Review of Current Knowledge

Ram¹,

Peñalver²,

Lo³

et al. 2019

Texas Heart Institute Journal

110

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Carcinoid heart disease is the collective term for all cardiac manifestations in patients who have carcinoid syndrome. Carcinoid heart disease has a multifactorial pathophysiology, and the right side of the heart is usually involved. Symptoms and signs vary depending upon the affected cardiac components; most typical is right-sided heart failure secondary to diseased tricuspid and pulmonary valves. Despite no single ideal diagnostic test, strong suspicion, coupled with serologic and imaging results, usually enables diagnosis. Advances in imaging, such as speckle-tracking echocardiography and cardiac magnetic resonance, have improved the diagnostic yield. Treatment is challenging, warrants a multidisciplinary approach, and can be medical or surgical depending on the cardiac manifestations. Investigators are exploring the therapeutic use of monoclonal antibodies and new somatostatin analogues. In this review, we cover current knowledge about the pathophysiology, diagnosis, and treatment of carcinoid heart disease.

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Section: Carcinoid Heart Diseasementioning

confidence: 99%

Carcinoid Heart Disease: Review of Current Knowledge

Ram¹,

Peñalver²,

Lo³

et al. 2019

Texas Heart Institute Journal

110

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“…To date, different imaging techniques have been employed for the diagnosis of cardiac metastases of carcinoid tumours. Several works have provided insights on the use of different imaging modalities to this end, varying from the readily available echocardiogram, 6 to the traditional In-111 Octreotide 7 or positron emission tomography 8 to CMR, 9 or combinations thereof. 10–12 Occasionally, biopsy of the mass is necessary for the diagnosis, 13 or the diagnosis is made post-mortem.…”

Section: Discussionmentioning

confidence: 99%

A concealed carcinoid cardiac metastasis uncovered by comprehensive cardiovascular magnetic resonance-based tissue characterization: a case report

Georgiopoulos

Mitropoulou

Masci

et al. 2020

European Heart Journal - Case Reports

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Background Cardiac metastases of carcinoid tumours are extremely rare, and their diagnosis poses a significant challenge. A variety of techniques has been reported in the literature for this purpose, ranging from echocardiogram to the Indium-111 Octreotide, positron emission tomography using specific tracers, and biopsy. Occasionally, the diagnosis is only made post-mortem. Recently, CMR (cardiovascular magnetic resonance) has been added to the diagnostic toolkit. This case report describes the CMR sequences that can be used to characterize cardiac metastases of carcinoid tumours. Case summary A 55-year-old woman with an antecedent history of resected carcinoid tumour of the ileocecal junction underwent whole-body In-111 Octreoscan single-photon emission computed tomography in the context of her follow-up. This raised the suspicion of pericardial involvement, which prompted a CMR study. Comprehensive CMR findings were consistent with isolated carcinoid tumour metastasis embedded within the anterior papillary muscle. We describe the CMR sequences that were used to characterize the metastasis. Discussion The rarity of cardiac metastasis of carcinoid tumour makes its diagnosis challenging and warrants a high level of clinical suspicion. Cardiovascular magnetic resonance imaging proves to be an indispensable tool in the tissue characterization of such tumours.

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“…5 Farooqui et al. 6 reported cardiac metastasis of a carcinoid neoplasm in the right ventricle, which was a solid and isolated mass connected with the interventricular septum. In addition, Gaur et al.…”

Section: Discussionmentioning

confidence: 99%

Cardiac metastasis of neuroendocrine tumor of the thymus diagnosed by cardiac magnetic resonance T1 mapping: a case report

Zhang

Zeng

2020

J Int Med Res

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Carcinoid heart disease is a late complication of carcinoid syndrome, and imaging can help in the diagnosis of diffuse cardiac metastasis. We herein report a case of diffuse cardiac metastasis of a neuroendocrine tumor of the thymus diagnosed using different imaging modalities. Cardiac magnetic resonance imaging played an important role in the diagnosis. The patient underwent conservative medical treatment and remained able to perform his usual activities of daily living.

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Utility of Indium-111 Octreotide to Identify a Cardiac Metastasis of a Carcinoid Neoplasm

Cited by 7 publications

References 9 publications

Carcinoid Heart Disease: Review of Current Knowledge

Carcinoid Heart Disease: Review of Current Knowledge

A concealed carcinoid cardiac metastasis uncovered by comprehensive cardiovascular magnetic resonance-based tissue characterization: a case report

Cardiac metastasis of neuroendocrine tumor of the thymus diagnosed by cardiac magnetic resonance T1 mapping: a case report

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