Utility of inhibin B in the management of male infertility

Ruiz-Plazas, Xavier; Gasión, J.P. Burgués; Moragues, Mariano Ozonas; Reus, P. Pizá

doi:10.1016/s2173-5786(10)70194-3

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…All three parameters (FSH, inhibin B and sperm concentration) rise during recovery and, at the end of that period, the physiological inverse relationship between inhibin B and FSH is restored. These data indicate that once pubertal testicular maturation has occurred and the normal compliment of spermatogenic cells is established, it is the number of Sertoli cells and their relationship with their compliment of germ cells that is the prime determinant of inhibin B production 1 . The dependence of sperm production on the number of Sertoli cells 50 , makes separation of the relative contributions of these two components difficult 43 .…”

Section: Resultsmentioning

confidence: 83%

“…This condition affects 15% of couples, and the male is responsible in 50% of cases. Standard tests to study infertility include spermiogram and hormonal profile 1 . The prevalence of infertility varies widely, being less in developed countries and more in developing countries where limited resources for investigation and treatment are available.…”

Section: Introductionmentioning

confidence: 99%

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Serum Levels of Male Oligospermia Glycoconjugate Inhibin B Hormone and A - L - Fucose in Kurdistani ( Iraq ) Populations

Ahmed¹,

Hasan²,

Rashid³

2012

MEJIM

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Objectives-To assess the role of inhibin B in the evaluation of male factor infertility as a prospective study. To determine normative levels of inhibin B and examine levels in relationship to FSH, sperm count, and motility in a cohort of fertile and infertile men from the Kurdistan region of Iraq. Materials and methods-Semen analysis was performed according to World Health Organization guidelines. An ELISA technique were applied for serum levels of inhibin B (ng/L), LH (mIU/L), FSH (mIU/L), and testosterone (ng/ml) assays. A colorimetric procedure was followed for the fucose and protein bound fucose levels determination. Results-A total of 55 infertile (oligospermia) and 87 presenting for fertility (normal) evaluations were recruited. The mean serum inhibin B level was significantly (P<0.05) lower in the oligospermia (18 ng/L) than normal group (24 ng/L). No significant differences were found in determination levels of fucose in both groups. Serum FSH and LH levels were significantly higher in oligospermia than in normal. Conclusion-Inhibin B levels in fertile men and infertile men in Kurdistan region were similar but not identical to those reported in other geographic regions. Both inhibin B and FSH are useful markers of spermatogenesis.

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Section: Resultsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Serum Levels of Male Oligospermia Glycoconjugate Inhibin B Hormone and A - L - Fucose in Kurdistani ( Iraq ) Populations

Ahmed¹,

Hasan²,

Rashid³

2012

MEJIM

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“…Нормальный уровень ингибина В лучше прогнозирует, чем ФСГ, более эф-фективна тестикулярная экстракция сперматозоидов для интрацитоплазматической инъекции сперматозо-ида [16]. Исходя из этого, некоторые авторы исполь-зовали уровень ингибина В как показатель подвиж-ности сперматозоидов для их экстракции из яичка и чрес кожной аспирации из придатка яичка.…”

Section: заключениеunclassified

“…X. Ruiz Plazas и соавт. (2012) про-анализировали диагностическую величину ингибина В как маркера сперматогенеза и его прогнозируемую величину для тестикулярного экстракта спермы у па-циентов с азооспермией [16]. Полученные нами данные позволяют констатиро-вать некоторые положения, которые должны быть ин-терпретированы следующим образом:…”

Section: заключениеunclassified

Serum inhibin B values in infertile patients

Абдуллоевич¹,

Москвичев²,

Фаниев³

2016

Androl. genit. hir.

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Polymorphisms in the HSF2 , LRRC6 , MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility

et al. 2022

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The aim of this study was to investigate the association of 24 functionally important single nucleotide polymorphisms (SNPs) with male infertility. In this cross-sectional study, we genotyped 24 functionally important single nucleotide polymorphisms in 24 infertility candidate genes in 500 oligo-/astheno-/oligoastheno-/normozoospermic infertile men with idiopathic infertility. Sequenom iPlex gold assay was used for genotyping. Sperm count and motility were compared between prevalent genotypes at each test locus. We did not observe any significant difference in the average sperm count between the alternate genotypes for the loci in the KLK3, LRRC6, MEIG1, HSF2, ESR2 and PTIP genes. However, we observed a significant difference in sperm motility between the alternate genotypes for the loci in the LRRC6, MEIG1, HSF2 and PTIP genes. Polymorphisms in the LRRC6 (rs200321595), MEIG1 (rs150031795), HSF2 (rs143986686) and PTIP (rs61752013) genes show association with sperm motility.

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Utility of inhibin B in the management of male infertility

Cited by 5 publications

References 26 publications

Serum Levels of Male Oligospermia Glycoconjugate Inhibin B Hormone and A - L - Fucose in Kurdistani ( Iraq ) Populations

Serum Levels of Male Oligospermia Glycoconjugate Inhibin B Hormone and A - L - Fucose in Kurdistani ( Iraq ) Populations

Serum inhibin B values in infertile patients

Polymorphisms in the HSF2 , LRRC6 , MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility

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