Utility of neurophysiological criteria in Guillain Barre΄ syndrome: Subtype spectrum from a tertiary referral hospital in India

Alexander, Mathew; Prabhakar, Appaswamy Thirumal; Aaron, Sanjith; Thomas, Maria; Mathew, Vivek; Patil, Anil Kumar

doi:10.4103/0028-3886.86548

Cited by 9 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The elevated protein in the CSF among GBS patients is due to damage of proximal nerve root (myelin or axon) which leads to, release of proteins into CSF(15).In consideration to the NCS; the prolongation of distal sensory and (or) motor latency and slowing of nerve conduction velocity are noted when the fastest and largest conducting nerve fibers are subjected to process of demyelination. While reduction in amplitude of sensory nerve action potential SNAP or compound muscle action potential CMAP mirrors the degree of axonal degeneration and indicates the decline of sensory fibers of nerves, as theaction potential appears to represent the summated action potential of the active fibers under the recording electrodes (16).The discrepancy between sensory conduction study between upper and lower limbs was 6.66% in only 2 patients in which the median nerve was abnormal whilst medial plantar nerve is normal, this result is similar toYe Y.et al2010 (12) while it is less than what was reported byAlexanderM.et al 2011 (17). This combination of changes between SNAP of upper and lower extremities could reflect an indication of an acquired demyelination disease specifically if it is noted with H-reflex absence (18).Another important parameter is H-reflex which was absent in 22 patients out of 30 patients (73.3%).…”

Section: Resultsmentioning

confidence: 55%

Electrophysiological evaluation of Guillain–Barre syndrome subtypes in childhood

Hussein¹,

Ali²,

Mohammed³

2017

J. Fac. Med Baghdad

View full text Add to dashboard Cite

Background: Guillain-Barre syndrome (GBS) is the most common cause of acute motor paralysis in children where most of electrophysiological findings reveal demyelinating neuropathy. However, an axonal form of Guillain-Barre syndrome had been reported too. Objectives: Assess the role of neurophysiological study (EMG and NCS) in the diagnosis of Guillain-Barre syndrome subtypes in children and estimate the frequency of subtypes whether demyelinating or axonal form of Guillain-Barre syndrome. Subjects and methods: Two study groups of either sex was involved, thirty (30) Guillain-Barre patients with different ages and thirty(30) normal healthy subjects matched for age and gender served as control group. Each subject submitted to sensory and motor nerve conduction study (NCS) and electromyography (EMG) of both upper and lower limbs. Results:The results of this study revealed that 24 (80%), 5 (16.7%), 1 (3.3%) had Acute inflammatory demyelinating polyneuropathy, Acute motor axonal neuropathy and Acute motor sensory axonal neuropathy respectively. The most affected age group was (3-6) years, and the majority of patients had a preceding infection in the past 3 months. Furthermore, 29 patients out of 30 had lost deep tendon reflexes and the H-reflex was absent in 22 (73.3%), however, the F-wave was absent in lower limbs more than upper limbs (46.6%) and (26.6%) respectively. The distal motor latency was abnormal in 121 (82.3%) nerves out of 147 total examined nerves. Conclusion:Acute inflammatory demyelinating polyneuropathy (AIDP) is the most frequent subtype of GBS, the change in sensory and motor NCS parameters was higher in lower limbs than upper limbs. Proximal segments are more vulnerable to demyelination rather than intermediate or distal nerve segments.

show abstract

Section: Resultsmentioning

confidence: 55%

Electrophysiological evaluation of Guillain–Barre syndrome subtypes in childhood

Hussein¹,

Ali²,

Mohammed³

2017

J. Fac. Med Baghdad

View full text Add to dashboard Cite

show abstract

“…Polyneuropathies show a significant degree of diversity due to their extreme variability in terms of speed of evolution, severity, mixture of sensory and motor changes, and presence or absence of certain symptoms. [8][9][10][11]…”

Section: Etiologymentioning

confidence: 99%

Guillain-Barre Syndrome as a Differential Diagnosis of Low Back Pain Syndrome

et al. 2016

View full text Add to dashboard Cite

Peripheral neuropathies are diseases of the lower motor neurons of the spinal cord and brainstem it can often mimic symptoms associated with the injuries of compressive radiculopathy. They are manifested by tingling, coldness, numbness, burning, pain, hypersensitivity, weakness, atrophy, postural hypotension, impotence, anhidrosis, and urinary incontinence. Therefore, it is important in the diagnostic strategy to keep in mind this type of pathology, especially when it comes to patients already in the 6th decade of life.

show abstract

“…En las últimas tres décadas, se han propuesto diferentes criterios electro diagnósticos, basados inicialmente en detectar lentificación de conducción nerviosa como evidencia de un proceso de desmielinización 27 , posteriormente con la descripción del subtipo axonal, estos criterios han sido reevaluados. Ninguno de ellos incluye hallazgos en electromiografía 28,29 .…”

Section: Estudio Electrofisiológicounclassified

“…Desde 1978, diversos investigadores han propuesto algunos criterios para establecer el diagnóstico de SGB, basados en demostrar la existencia de desmielinización en 2 o más nervios usando distintos puntos de corte en los parámetros de neuroconducción motora. (Velocidad de conducción, latencia distal, dispersión temporal y bloqueo de conducción) 25,27,29,30 . La presencia de desmielinización en dos o más nervios motores, confirma la AIDP, con puntos de corte de latencias distales de más del 110% del límite superior normal (Tabla 2) 27 .…”

Section: Criterios Electrodiagnósticosunclassified

Estudio electrodiagnóstico en síndrome de Guillain Barré en adultos

2016

Rev. chil. neuro-psiquiatr.

View full text Add to dashboard Cite

Guillain Barré syndrome is an acute polyradiculoneuropathy with different forms of presentation and is currently the leading cause of acute arreflexic paralysis in the world, its diagnosis is clinical and additional assesment as electrodiagnosis are used for differential diagnosis, rank among the variants (demyelinating or axonal) and define prognosis. The purpose of this paper is to make a narrative review of the literature, emphasizing the electrophysiological study, describing early findings, the most common mistakes, while highlighting the importance of classification chart to guide actions towards rehabilitation and functional recovery.

show abstract

Utility of neurophysiological criteria in Guillain Barre΄ syndrome: Subtype spectrum from a tertiary referral hospital in India

Abstract: In this study 44% patients had axonal forms of the disease, 38.2% patients had AIDP subtype and 17% remained unclassified. The most sensitive criteria to identify AIDP were the criteria proposed by Albers and colleagues and the Dutch group.

Cited by 9 publications

References 18 publications

Electrophysiological evaluation of Guillain–Barre syndrome subtypes in childhood

Electrophysiological evaluation of Guillain–Barre syndrome subtypes in childhood

Guillain-Barre Syndrome as a Differential Diagnosis of Low Back Pain Syndrome

Estudio electrodiagnóstico en síndrome de Guillain Barré en adultos

Contact Info

Product

Resources

About