Utility of ovarian biopsy in pancreatic metastasis of high-grade serous ovarian carcinoma: A case report

Abstract

Abstract. It is very rare that ovarian carcinoma metastasizes to the pancreas, and pathological diagnosis is required to confirm the primary site. The present study reported a 73-year-old woman with serous carcinoma of the ovary that metastasized to the tail of the pancreas. Metastasis was confirmed by pathological and immunohistochemical examination of a biopsy of the ovarian tumor, an endoscopic ultrasound-guided fine-needle aspiration biopsy of the pancreatic tumor and computerized tomography-guided paraaortic lymph node biopsy. A biopsy of the ovarian tumor is useful to make a precise diagnosis and to determine proper treatment when ovarian and pancreatic tumors are identified at the same time and the primary neoplasm is uncertain.

miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

“…In rare occurrence, much further metastatic sites of the ovarian carcinoma have also been reported such as in the brain ( Koul et al, 2001 ; Sekine et al, 2013 ; Longo et al, 2014 ), breast ( Dursun et al, 2009 ; Karam et al, 2009 ; Abbas et al, 2013 ; Tempfer et al, 2016 ), lung ( Carbonari et al, 2015 ; Upadhyay et al, 2015 ), pancreas ( Nakamura et al, 2016 ), and gastrointestinal track ( Zhou and Miao, 2012 ), thus suggesting an alternative route of metastasis in EOC. Previous studies have reported that the presence of circulating tumor cells (CTCs) in the blood circulation of the ovarian cancer patients ( Pecot et al, 2011 ; Phillips et al, 2012 ), which implies that ovarian tumor cells may also follow ‘hematogenous’ route of metastasis through blood stream.…”

Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Diagnosis of Pancreatic Metastases Secondary to Ovarian Carcinoma

“… 1 – 3 Pancreatic metastases from ovarian carcinoma are rare, with only 17 cases cited in the literature. 4 , 5 Unlike most other cancers, ovarian carcinoma is primarily locally invasive, with spread to other reproductive organs such as the uterus and fallopian tubes, liver, spleen, and sigmoid colon. It is important to correctly determine the origin of pancreatic lesions since there are different treatments and prognoses in patients with primary pancreatic cancer compared with metastatic cancer to the pancreas from other primary malignancies, such as ovarian carcinoma.…”