Utility of single photon emission computed tomography perfusion scans in radiation treatment planning of locally advanced lung cancers

Agrawal, Sushma; Raj, Mithun; Kheruka, Subhash Chand; Das, KJ Maria; Gambhir, Sanjay

doi:10.4103/0972-3919.108830

Cited by 11 publications

(9 citation statements)

References 15 publications

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“…Prior studies have attempted to utilize functional respiratory imaging, predominantly SPECT, in addition to standard DVH parameters to better predict lung toxicity. [28][29][30][31] The results of these initial studies have been promising, and obtaining pretreatment functional respiratory imaging may have improved our ability to determine factors that predict PFT decline.…”

Section: Discussionmentioning

confidence: 99%

Changes in Pulmonary Function Following Image-Guided Stereotactic Lung Radiotherapy

Stone

Mangona

Johnson

et al. 2015

Journal of Thoracic Oncology

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As the largest cohort of patients with prospective follow-up PFT evaluation after lung SBRT, this supports the safety of SBRT in this population of predominantly medically inoperable patients. While statistically significant, nearly all declines in PFTs would be rated as a grade 1 on the Radiation Therapy Oncology Group scale, demonstrating safety. PFT declines were not associated with worse overall survival.

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Section: Discussionmentioning

confidence: 99%

Changes in Pulmonary Function Following Image-Guided Stereotactic Lung Radiotherapy

Stone

Mangona

Johnson

et al. 2015

Journal of Thoracic Oncology

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“…The addition of CT to SPECT and PET can be accurately co-registered to CT planning images. In the cases of SPECT without CT acquisition, the markers have been proposed to be used to better match the SPECT images to the CT planning images 14,17,29 . A SPECT scan takes about 12-20 min.…”

Section: Discussionmentioning

confidence: 99%

Single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging for radiotherapy planning in patients with lung cancer: a meta-analysis

Lee

Park

2020

Sci Rep

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Functional imaging modalities enable practitioners to identify functional lung regions. This analysis evaluated the feasibility of nuclear medicine imaging to avoid doses to the functional lung in radiotherapy (RT) planning for patients with lung cancer. This systematic review and meta-analysis was carried out according to PRISMA-P guidelines. A search of EMBASE and PubMed for studies published throughout the last 20 years was performed using the following search criteria: (a) ‘lung cancer’ or ‘lung malignancy’ and (b) ‘radiotherapy’ or ‘radiation therapy’ or ‘RT planning’ and (c) ‘SPECT’ or ‘single positron emission computed tomography’ or ‘functional image.’ The analyzed planning parameters were the volumes of the normal lung that have received ≥ 10 Gy and ≥ 20 Gy of radiation (V10 and V20, respectively) and the mean lung dose (MLD). We compared the planning parameters obtained from anatomical RT planning and functional RT planning using perfusion or ventilation imaging (‘V10, V20 or MLD’ in anatomical plan vs. ‘fV10, fV20 or fMLD’ in functional plan). A total of 309 patients with 344 RT plan sets from 15 publications (11 perfusion SPECT, 2 ventilation SPECT, and 1 SPECT and 1 PET with both perfusion and ventilation) were included in the meta-analysis. The standard mean differences in planning parameters in functional plans using nuclear imaging were significantly reduced compared to those of anatomical plans (P < 0.01 for all): − 0.42 (95% confidence interval (CI) − 0.78 to − 0.07) for ‘V10 vs. fV10′, − 0.41 (95% CI − 0.64 to − 0.17) for ‘V20 vs. fV20′, and − 0.24 (95% CI − 0.45 to − 0.03) for ‘MLD vs. fMLD’. In subgroup analysis, the functional plan using perfusion was significantly lower than the anatomical plan in all planning parameters, but there was no significant difference for ventilation. RT planning with nuclear functional lung imaging has potential to reduce radiation-induced lung injury. Perfusion imaging seems to be more promising than ventilation imaging for all planning parameters. There were not enough studies using ventilation imaging to determine what the effect is on the lung plan parameters.

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“…Functional lung imaging should, therefore, be considered during treatment planning. 29 Several studies have proposed to optimize a treatment plan for lung cancer based on either perfusion [30][31][32][33][34] or ventilation 35 information. Applications in radiation therapy are also foreseen using functional imaging provided by DECT.…”

Section: Introductionmentioning

confidence: 99%

Assessing lung function using contrast‐enhanced dual‐energy computed tomography for potential applications in radiation therapy

et al. 2017

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Utility of single photon emission computed tomography perfusion scans in radiation treatment planning of locally advanced lung cancers

Cited by 11 publications

References 15 publications

Changes in Pulmonary Function Following Image-Guided Stereotactic Lung Radiotherapy

Changes in Pulmonary Function Following Image-Guided Stereotactic Lung Radiotherapy

Single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging for radiotherapy planning in patients with lung cancer: a meta-analysis

Assessing lung function using contrast‐enhanced dual‐energy computed tomography for potential applications in radiation therapy

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