Utility of the Monoclonal Antibody HIK1083 in the Diagnosis of Adenoma Malignum of the Uterine Cervix

Utsugi, Kuniko; Hirai, Yasuo; Takeshima, Nobuhiro; Akiyama, Futoshi; Sakurai, Shigeru; Hasumi, Katsuhiko

doi:10.1006/gyno.1999.5622

Cited by 56 publications

(20 citation statements)

References 6 publications

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“…It was limited to neoplastic conditions in a study of benign, premalignant and malignant endocervical glandular lesions [12]. Some markers such as HIK1083 and the intestinal mucin gene MUC2, which have been regarded as surrogate for intestinal metaplasia, were also limited in neoplastic conditions [13,14,15]. …”

Section: Discussionmentioning

confidence: 99%

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

Zhu

2012

Acta Cytologica

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Objective: Neuroendocrine carcinoma (NEC) of the uterine cervix is a highly aggressive type of tumor. Therefore, recognition of its cytology and histopathology is important for early diagnosis. Study Design: We report 6 cases of small-cell and 6 cases of large-cell NEC of the uterine cervix, including 5 cytology slides. AE1/3, CEA, p63, p16, CD56, chromogranin and synaptophysin were detected. Results: Two cytology slides of small-cell NEC showed sheet-like clusters. The tumor cells were uniformly small, with finely granular chromatin, scant cytoplasm and absent nucleoli. Three large-cell NEC smears showed palisading, molding and abortive rosettes with prominent eosinophilic nucleoli. The tumor cells had either abundant cytoplasm or no cytoplasm at all. The histopathology analysis indicated a transition from dysplasia glands or adenocarcinoma in situ glands to NEC in 6 cases. Conclusion: Cervical cytology of NEC has many unique characteristics, distinct from the characteristics of other lesions. We also demonstrated a hypothesis of the histogenesis of some NECs.

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Section: Discussionmentioning

confidence: 99%

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

Zhu

2012

Acta Cytologica

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“…2,3 This antibody has since then been regarded as a promising diagnostic tool for MDAs. 4,5 However, its usefulness has been in dispute and Mikami et al 6,7 have demonstrated HIK1083 reactivity in pyloric gland metaplasia (PGM) of the cervix, which was described as lobular endocervical glandular hyperplasia (LEGH) by Nucci et al 8,9 These facts have provoked controversy concerning a possible link between LEGH/ PGM and MDA, and whether gastric phenotype is specific for these two conditions. In the current study, we have examined cervical adenocarcinomas including MDAs, adenocarcinoma in situ (AIS), and LEGH/PGM as well as a variety of benign glandular lesions to determine the incidence of gastric phenotypes and to shed light on the issue of histogenesis of MDA, employing antibodies to apomucins encoded by the MUC gene family, CD10 and chromogranin A (CGA), and HIK1083 and anti-p16 INK4 , the last for showing any relationship to high-risk HPV.…”

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Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and ‘adenoma malignum‘

et al. 2004

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Gastrointestinal phenotype in cervical adenocarcinomas was examined by immunohistochemistry and correlated with morphologic features. Antibody panels included anti-MUC2, MUC6, CD10, chromogranin A (CGA) and HIK1083. In addition, expression of p16 INK4 , a cyclin-dependent kinase inhibitor which is expressed in a variety of high-risk HPV-related conditions, was studied. A total of 94 invasive adenocarcinomas including 20 minimal deviation adenocarcinomas (MDAs) and 72 adenocarcinomas in situ (AIS) were examined. MDAs were most frequently positive for HIK1083 and/or MUC6, two representative gastric markers, with a rate of 95%, followed by intestinal-type adenocarcinomas (IAs) with a rate of 85% whereas only 27% of 56 usual endocervical-type adenocarcinomas (UEAs) were positive. MUC2, a goblet cell marker, was positive in 85% and 25% of IAs and MDAs, respectively, while in only 14% of UEAs. CD10 was positive in 15% of IAs, indicating incomplete intestinal differentiation without a brush border in most of the cases. CGA-positive cells were frequently seen in MDAs and IAs with rates of 60% and 62%, respectively. Nuclear and cytoplasmic p16 INK4 positivity was identified in 93% of UEAs, whereas 30% of MDAs were positive for p16 INK4 . Results in AISs were comparable to their invasive counterparts, but morphologically usual-type AISs identified in eight cases of MDA were frequently positive for HIK1083 (75%) and MUC6 (63%), and p16 INK4 . Of note was the existence of lobular endocervical glandular hyperplasia (LEGH) with atypical features including cytologic abnormalities, and/or papillary projection, which were identified in this study in pure form (n ¼ 3) or in association with MDAs (n ¼ 6), but not in cases of other types of adenocarcinomas. These observations indicate that gastrointestinal phenotype is frequently expressed in MDAs and IAs, and there seems to be a possible link between MDA, and LEGH and morphologically usual-type AIS with gastric immunophenotype in histogenesis. Frequent absence of p16 INK4 expression in MDAs suggests a possibility that high-risk HPV does not play a crucial role in development of MDAs, in contrast to the majority of endocervical adenocarcinomas. p16 INK4 immunohisto-

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“…Steeper and Wick (1986) reported that positive staining for CEA was helpful in supporting the diagnosis of MDA, but others have shown CEA reactivity only focally in MDA (Gilks et al, 1989;Toki et al, 1997). Ishii et al (1998Ishii et al ( , 1999 and Utsugi et al (1999) demonstrated by using the monoclonal antibody HIK1083 that gastric mucin was present in 90% of MDAs and in 30% to 57% of mucinous adenocarcinomas but not in normal endocervical glands. Gastric mucins have been demonstrated not only in the cytoplasm of the MDA tumor cells but also in cervical glands showing a metaplastic change to a pyloric gland morphology, which would make distinguishing pyloric gland metaplasia from an early stage of MDA very difficult (Mikami et al, 1999).…”

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confidence: 99%

Mutations in the STK11 Gene Characterize Minimal Deviation Adenocarcinoma of the Uterine Cervix

Kuragaki

Enomoto

Ueno

et al. 2003

Laboratory Investigation

107

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Utility of the Monoclonal Antibody HIK1083 in the Diagnosis of Adenoma Malignum of the Uterine Cervix

Cited by 56 publications

References 6 publications

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

Gastrointestinal immunophenotype in adenocarcinomas of the uterine cervix and related glandular lesions: a possible link between lobular endocervical glandular hyperplasia/pyloric gland metaplasia and ‘adenoma malignum‘

Mutations in the STK11 Gene Characterize Minimal Deviation Adenocarcinoma of the Uterine Cervix

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