Utilización de aprotinina como agente hemostático en la prótesis total de cadera

Study of the Influence of Bone Cement Type and Mixing Method on the Bioactivity and the Elution Kinetics of Ciprofloxacin

“…Simulations were performed for the three days post-surgery, using the clearance of synovial liquid values previously reported (20.42 ± 11.3 mL/h for the first day; 9.33 ± 11.02 mL/h for the second day and 4.11 ± 2.95 mL/h for the third day) [28] and considering that the distribution of the antibiotic from the location of the implant to the systemic circulation is negligible. Bioactivity was evaluated using MIC distributions for Pseudomonas aeruginosa (MIC = 0.25-1 μg/mL), S. aureus (MIC = 0.12-0.5 μg/mL) and Escherichia coli (MIC = 0.016-0.004 μg/mL) [29] and calculating the percentage of patients whose levels of antibiotic at the site of the implant would be higher than the MIC.…”