Utilization of Alkaline Phosphatase Measurements in Veterinary Practice

McComb, Robert B.; Bowers, George N.; Posen, Solomon

doi:10.1007/978-1-4613-2970-1_10

Cited by 1 publication

(1 citation statement)

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“…However, measurement of total ALP activity in cattle is of limited diagnostic value, even for hepatic disease, due to the broad range of reference values (0-500 U/L; Jackson and Cockcroft 2002). Some variability in cattle can be attributed to breed differences, with Bos indicus breeds having higher concentrations than Bos taurus breeds within age groups (Kunkel et al 1953;Gahne 1967;McComb et al 1979). It is possible to increase the specificity of total ALP tests for the bone-specific isoform by using lectin precipitation and heat inactivation before testing, and, in general, this has yielded more definitive results.…”

Section: Balp As a Marker Of Bone Mineralisationmentioning

confidence: 99%

New candidate markers of phosphorus status in beef breeder cows

et al. 2017

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Determining the phosphorus (P) status of cattle grazing P-deficient rangelands in northern Australia is important for improving animal production in these areas. Plasma inorganic P concentration is currently the best diagnostic marker of dietary P deficiency in growing cattle but is not suitable for assessing the P status of breeder cows, which often mobilise substantial bone and soft tissue reserves in late pregnancy and lactation. Markers of bone turnover offer potential as markers of P status in cattle, as they reflect bone mobilisation or bone formation. Recent experiments investigating the physiology of beef breeder cows during diet P deficiency have indicated that the ratio of plasma total calcium concentration to plasma inorganic P concentration might be suitable as a simple index of P deficiency. However, a more specific measure of increased bone mobilisation in P-deficient breeders is plasma concentration of C-terminal telopeptide of Type 1 collagen. Also, plasma concentration of bone alkaline phosphatase is a marker of defective bone mineralisation in dietary P deficiency. These candidate markers warrant further investigation to determine their predictive value for P deficiency in cattle.

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Section: Balp As a Marker Of Bone Mineralisationmentioning

confidence: 99%