2012
DOI: 10.1016/j.theriogenology.2011.12.008
|View full text |Cite
|
Sign up to set email alerts
|

Utilization of endogenous fatty acid stores for energy production in bovine preimplantation embryos

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

6
81
0
9

Year Published

2012
2012
2018
2018

Publication Types

Select...
7
1

Relationship

1
7

Authors

Journals

citations
Cited by 104 publications
(96 citation statements)
references
References 32 publications
6
81
0
9
Order By: Relevance
“…The absence of exogenous carnitine may lead to developmental anomalies in the early human embryo, which may be linked to deficiencies in lipid metabolism: this aspect can be relevant especially in women over 37. A lower level of glucose metabolism, associated with mitochondria aging [18][19][20][21] and an absence of lipid metabolism may lead to a lack of ATP and developmental arrest before blastocyst formation, as mitochondria replication only starts at this stage. Preliminary experiments have shown that in mouse, addition of carnitine can improve blastocyst development in vitro [22]: a high concentration does not seem important but its "catalytical" role seems relevant.…”
Section: Discussionmentioning
confidence: 99%
“…The absence of exogenous carnitine may lead to developmental anomalies in the early human embryo, which may be linked to deficiencies in lipid metabolism: this aspect can be relevant especially in women over 37. A lower level of glucose metabolism, associated with mitochondria aging [18][19][20][21] and an absence of lipid metabolism may lead to a lack of ATP and developmental arrest before blastocyst formation, as mitochondria replication only starts at this stage. Preliminary experiments have shown that in mouse, addition of carnitine can improve blastocyst development in vitro [22]: a high concentration does not seem important but its "catalytical" role seems relevant.…”
Section: Discussionmentioning
confidence: 99%
“…Esta maior exposição ao oxigênio faz com que ocorra uma produção de radicais livres. Altos níveis de radicais livres causam danos celulares, levando à perda de suas funções (Yang et al, 1998). Os radicais livres gerados in vitro, como o superóxido, o peróxido de hidrogênio e a hidroxila, reagem com as proteínas celulares, os lipídeos e o DNA, resultando na inativação enzimática, na peroxidação lipídica da membrana e em alterações do DNA (Andrade et al, 2010;Silva et al, 2011).…”
Section: Discussionunclassified
“…A MIV é influenciada por diferentes fatores, como atmosfera gasosa, meio de cultivo, temperatura, suplementação proteica e fatores de crescimento (Santos et al, 2002;Sutton-McDowall et al, 2012). Avanços significantes foram obtidos modificando-se os meios de cultivo embrionários, o que resultou no aumento da taxa na produção in vitro (PIV) de embriões.…”
Section: Introductionunclassified
See 1 more Smart Citation
“…There is a growing body of literature describing the importance of fatty acid beta-oxidation as a source of energy during oocyte IVM (Ferguson and Leese, 2006;Sturmey et al, 2006;Downs et al, 2009;Dunning et al, 2010;Dunning and Robker, 2012;Valsangkar and Downs, 2013;Dunning et al, 2014b;Paczkowski et al, 2014). This is not surprising when one considers the energy dense nature of fatty acids with the potential to produce 106 ATP molecules from a single fatty acid, greater than 3.5-fold the capacity of a single glucose molecule.…”
Section: Importance Of Beta-oxidation and Its Modulation By L-carnitimentioning
confidence: 99%