Utilization of Glucose-6-Phosphate Dehydrogenase Test and the Prevalence of Enzyme Deficiency in Korea

Choi, Rihwa; Park, Wonseo; Chun, Gayoung; Lee, Sang Gon; Lee, Eun Hee

doi:10.3390/jcm12093179

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…The study focused on women of reproductive age, categorized into the following age groups: 20–24, 25–29, 30–34, 35–39, 40–44, and 45–49 years. Geographical regions were classified into six groups based on administrative districts and their proximity [ 36 ]. The groups were: (1) Seoul, Incheon, and Gyeonggi-do, (2) Gangwon-do, (3) Chungcheong province, (4) Jeolla province, (5) Gyeongsang province, and (6) Jeju Island [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

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The Utilization of Serum Folate and Homocysteine Tests and the Prevalence of Folate Deficiency in Reproductive-Age Korean Women during the COVID-19 Pandemic

et al. 2023

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We investigated the prevalence of folate deficiency and associated factors in a large population of Korean women of reproductive age during the COVID-19 pandemic. We utilized different cut-offs and evaluated age, year of testing, geographical region, and the utilization of serum homocysteine levels. Out of the 27,758 women evaluated, the overall prevalence of folate deficiency was 12.5% (<4 ng/mL, metabolic indicator) and 5.4% (<3 ng/mL, hematologic indicator). Homocysteine testing was observed in 8.4% of women, with 2.7% having elevated homocysteine levels (>15.4 µmol/L). According to our multiple logistic regression analysis, younger women, particularly those aged 20 to 24 years, tested in 2020, and from Jeolla province, Gyeongsang province, and Jeju Island, were identified as being more prone to folate deficiency. Receiver operating characteristic curve analysis demonstrated that a cut-off of >8.4 µmol/L provided the most accurate definition of folate deficiency with serum folate levels <4 ng/mL, while a cut-off of >8.8 µmol/L best defined folate deficiency with serum folate levels <3 ng/mL, with both cut-offs being lower than 15.4 µmol/L. Our study emphasizes the prevalence of folate deficiency, associated factors, and the role of homocysteine in planning nutritional support programs in Korea.

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Section: Methodsmentioning

confidence: 99%

“…Geographical regions were classified into six groups based on administrative districts and their proximity [ 36 ]. The groups were: (1) Seoul, Incheon, and Gyeonggi-do, (2) Gangwon-do, (3) Chungcheong province, (4) Jeolla province, (5) Gyeongsang province, and (6) Jeju Island [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

The Utilization of Serum Folate and Homocysteine Tests and the Prevalence of Folate Deficiency in Reproductive-Age Korean Women during the COVID-19 Pandemic

et al. 2023

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“…To create maps of the prevalence of diminished ovarian reserve by geographic region, we grouped the administrative districts of Korea into six categories based on geographic proximity and regional codes available in the laboratory information system [19]. The number of total Korean women by geographic region was collected from a public database of the Korean Statistical Information Service (KOSIS) for the resident registry population (https://kosis.kr/index/index.do; accessed on 10 April 2023) [20].…”

Section: Definitionsmentioning

confidence: 99%

Investigation of the Prevalence of Diminished Ovarian Reserve in Korean Women of Reproductive Age

Choi

Park

Chun

et al. 2023

JCM

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Diminished ovarian reserve can be assessed biochemically using serum anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) tests. This study aimed to evaluate the prevalence of diminished ovarian reserve in a large population of reproductive-aged women by age and geographic region in Korea using different cutoffs of serum AMH and FSH levels. In 2022, 13,351 women underwent both AMH and FSH tests. The prevalence of diminished ovarian reserve increased markedly with age. Although cutoffs for AMH and FSH levels are different in USA and Korean guidelines, the overall prevalence of diminished ovarian reserve was comparable. The maximum prevalence was 3.8%, 6.0%, 11.0%, 28.6%, 69.3%, and 95.0% in women aged 20–24, 25–29, 30–34, 35–39, 40–44, and 45–49 years, respectively. The overall prevalence and age-adjusted prevalence of diminished ovarian reserve were 37.2% and 38.4%, respectively. Women who had only increased serum FSH without decreased AMH represented 1.1% (by Korean guidelines) and 2.5% (by USA guidelines) of all women. Serum AMH and FSH tests were underutilized on Jeju Island. The results of this study provide basic knowledge about diminished ovarian reserve for use in infertility support programs and the field of maternal aging.

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Optimizing Testing Time for Methaemoglobin Reduction Test in G6PD Screening: A Comparative Experimental Study between the Monica Cheesbrough Protocol and the Asutifi North District Hospital Protocol at Asutifi North District Hospital, Ghana.

Duneeh,

Appiah-Intsiful,

Bedzina

et al. 2024

Preprint

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Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder caused by a genetic defect in the red blood cell enzyme G6PD, affecting around 500 million people worldwide. The study investigated the optimum methaemoglobin reduction test (MRT) reaction time for diagnosing G6PD deficiency among patients at Asutifi North District Hospital using Monica Cheesbrough protocol and Asutifi North District Hospital Protocol. Methodology: The study was an experimental study conducted with 643 participants from April, 2024 to July, 2024. The Monica Cheesbrough MRT and the Asutifi North Hospital MRT protocols, were compared at various time points (T90, T120, T150, and T180 minutes). Intraclass Correlation Coefficient (ICC) and Kappa statistics were used to assess reliability and agreement between the results from the two protocols. McNemar's test was utilized to analyse G6PD status differences between the protocols. The prevalence of G6PD deficiency was also determined. Data analysis was done using IBM Statistical Package for the Social Sciences version 26.0 (2019. Armonk, NY: IBM Corp). P-value less than 0.05 was considered statistically significant for all analysis. Results: T90 ICC values were very low (0.005-0.007), indicating poor agreement. From T120 onwards, ICC values were high (0.967-0.996, p<0.001), demonstrating excellent reliability. Significant differences in G6PD status were found at T90 (p<0.001), with diminishing differences at later time points. Kappa values indicated slight agreement at T90 (K=0.164, p<0.001) and perfect agreement from T120 onwards (K=1.000, p<0.001). The majority of participants 606 (94.2%) had normal G6PD status, 29 (4.5%) had a fully defective enzyme, and 8 (1.2%) had a partially defective enzyme activity. Conclusion: The study found the optimum MRT reaction to be 120 minutes. The study also emphasized lesser volumes of blood samples and reagent give accurate results in the optimum time established. These insights can help in both sample and reagent management especially amongst paediatric patients where it is difficult taking very large volumes of blood for testing.

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Utilization of Glucose-6-Phosphate Dehydrogenase Test and the Prevalence of Enzyme Deficiency in Korea

Cited by 4 publications

References 16 publications

The Utilization of Serum Folate and Homocysteine Tests and the Prevalence of Folate Deficiency in Reproductive-Age Korean Women during the COVID-19 Pandemic

The Utilization of Serum Folate and Homocysteine Tests and the Prevalence of Folate Deficiency in Reproductive-Age Korean Women during the COVID-19 Pandemic

Investigation of the Prevalence of Diminished Ovarian Reserve in Korean Women of Reproductive Age

Optimizing Testing Time for Methaemoglobin Reduction Test in G6PD Screening: A Comparative Experimental Study between the Monica Cheesbrough Protocol and the Asutifi North District Hospital Protocol at Asutifi North District Hospital, Ghana.

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