Utilization of nonsteroidal antiinflammatory drugs

Abstract

Information derived from pharmaceutical marketing databases on the use of 12 nonsteroidal antiinflammatory drugs in 1983 is presented. Estimates of population exposure, regularity of treatment, average daily dose, age and sex distributions of users, concomitant use of other drugs, associated diagnoses, and trends in use are provided. Utilization patterns were similar for 8 of the nonsteroidal antiinflammatory drugs, with differing patterns seen for mefenamic acid, oxyphenbutazone, phenylbutazone, and zomepirac.

Early aseptic loosening of cemented total hip arthroplasty: the influence of non-steroidal anti-inflammatory drugs and smoking

“…NSAIDS are the most commonly prescribed drug class in the world [1]. They have been found to adversely affect prostaglandin-mediated bone remodelling in vitro and in animals in a dose-dependent fashion [8].…”

Heterotopic ossification prophylaxis with indomethacin increases the risk of long-bone nonunion

“…Nonunion was classified as atrophic, hypertrophic or oligotrophic. 28 The records and radiographs were reviewed by observers who were not involved in the care of the patients or in determining the method of prophylaxis or in the decision as to whether or not the fracture should be considered as a nonunion. Statistical analysis.…”

Informed consent and the prescription of nonsteroidal antiinflammatory drugs

“…Fifty-five percent of visits to physicians for arthritis result in the prescription of an NSAID (8). Although NSAIDs are generally well tolerated, they may have substantial toxicity.…”