Utilization of Pelvic Ultrasonography and CA125 Level to Diagnose Uterine Myoma and Adenomyosis

Elela, Nadia Khairy Fathi Abou; Suliman, Mohamed Mohamed Abd Alsalam; Soliman, Dina Mohamed Gamal Eldin; Zaki, Sara Atef; Ibrahim, Ragab Alsayed Amin; Mohammed, Mostafa Gamal Abdelhaleem

doi:10.21608/ejhm.2022.246932

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Our radiologic findings, when paired with biochemical analyses performed shortly after surgery, can provide insight into the uterine complexity encountered in our patient. The elevated CA 125 and CA 153 levels lie far beyond the typical level of uterine leiomyoma for a given uterine size and are still lower than the typical expression levels used to indicate malignancy [ 16 ]. Notably, the patient's uterine mass was visualized using [ 18 F]FDG PET/CT, which revealed intense [ 18 F]FDG uptake with a maximum standardized uptake value (SUVmax) of 26.3.…”

Section: Discussionmentioning

confidence: 99%

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Al-Ibraheem,

Abdulrahman,

Abdlkadir

et al. 2023

Cureus

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Over the past decade, a series of rare and extraordinary uterine tumors have been discovered, with some featuring exceptionally uncommon tumor types. This highlights the growing recognition of these rare tumors due to evolutionary radiologic advancements. However, evaluating these patients requires adequate understanding to avoid misinterpretation and potential confusion with alternative differential diagnoses. This case is the first documented instance of two coexistent uterine benign tumors in a 45-year-old unmarried female patient. The patient's medical, gynecological, and surgical histories were unremarkable. Conventional abdominopelvic imaging via computed tomography (CT) and magnetic resonance imaging (MRI) revealed significant uterine expansion, indicating an atypical leiomyomatous or potentially leiomyosarcomatous mass. Subsequently, [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) positron emission tomography (PET)/CT revealed hypermetabolic uterine enlargement, suggesting further evaluation. The patient underwent radical hysterectomy, and histopathological analysis revealed multiple uterine fibroids concurrently existing against the uterine angiomatosis. This case is the first documented instance of intricate pathological interplay within the uterus.

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Section: Discussionmentioning

confidence: 99%

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Al-Ibraheem,

Abdulrahman,

Abdlkadir

et al. 2023

Cureus

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Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis

Huang,

Zhou,

Chen

et al. 2024

Open Medicine

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This study aimed to investigate the changes of serum carbohydrate antigen 125 (CA125) and prostaglandin E2 (PGE2) in patients with adenomyosis before and after treatment with high-intensity focused ultrasound (HIFU) combined with gonadotropin-releasing hormone agonist (GnRH-a). One hundred and sixty-five patients with adenomyosis who received HIFU combined with GnRH-a were selected as case group. Sixty-five healthy women who underwent physical examination at the same time were taken as normal control group. At the end of follow-up 6 months after treatment, the case group were divided into effective subgroup and ineffective subgroup according to clinical efficacy. Changes of serum CA125 and PGE2 were analyzed. Serum CA125 and PGE2 levels in the case group were higher than those in the normal control group before treatment (both P < 0.001). Serum CA125 and PGE2 levels in the case group 6 months after treatment were lower than those before treatment (both P < 0.001). There was no difference in serum CA125 and PGE2 levels between effective subgroup and ineffective subgroup before treatment (P = 0.351, 0.284, respectively). Serum CA125 and PGE2 levels in the effective subgroup were lower than those in the ineffective subgroup 6 months after treatment (both P < 0.001). Serum CA125 and PGE2 may be involved in the development of adenomyosis, and their expression levels may be related to the prognosis of patients. Levels of serum CA125 and PGE2 in patients with adenomyosis decrease after treatment with HIFU combined with GnRH-a. The detection of serum CA125 and PGE2 may be used as an index to diagnose adenomyosis and evaluate the therapeutic effect of HIFU combined with GnRH-a.

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Utilization of Pelvic Ultrasonography and CA125 Level to Diagnose Uterine Myoma and Adenomyosis

Cited by 2 publications

References 9 publications

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Changes of serum CA125 and PGE2 before and after high-intensity focused ultrasound combined with GnRH-a in treatment of patients with adenomyosis

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