Utilization ofrGO‐PEI‐supportedAgNPsfor sensitive recognition of deltamethrin in human plasma samples: A new platform for the biomedical analysis of pesticides in human biofluids

Abstract

In this study, the rGO-PEI-AgNPs sensor was designed as a new effective platform to sensitive monitoring of deltamethrin in human plasma samples. For this purpose, reduced graphene oxide (rGO)-supported polyethylenimine (PEI) was used as a suitable substrate for dispersion of silver nanoparticles (AgNPs) as amplification and catalytic element. Therefore, a novel interface (rGO-PEI-AgNPs) was prepared by the fully electrochemical method on the surface of glassy carbon electrodes. The engineered nano-sensor showed a wide dynamic range of 10 nM to 1 mM and low limit of quantification (LLOQ) as 10 nM in human plasma sample, which revealed excellent analytical performance for the recognition of deltamethrin with high sensitivity and reproducibility through differential pulse voltammetry and square wave voltammetry techniques. The results confirm that rGO-PEI-AgNPs as a novel biocompatible interface can provide appropriate, reliable, affordable, rapid, and user-friendly diagnostic tools in the detection of deltamethrin in human real samples.

Aptasensing of ciprofloxacin residue using graphene oxide modified with gold nanoparticles and branched polyethyleneimine

“…19 Likewise, owing to the incorporating of PEI polymer with various inorganic NPs, the therapeutic potential of nanosystems for biological activities can be meaningfully enhanced through their physical characteristics. [20][21][22] In sum, the application of gold nanoparticle (AuNPs) and PEIs can enhance the signal rate, which lead to increases of intensity and prompting us to investigate the signicant role of the dendrimer building of PEIs, AuNPs and GO as the suggested matrix for electro-oxidation of CFX. Given the properties of the nanostructures applied in the proposed polymer substrate, it is estimated that the interaction area of the target with the modied electrode will be signicantly amplied.…”

An Electrochemical Immunosensor Based on SPA and rGO-PEI-Ag-Nf for the Detection of Arsanilic Acid

“…Polyethyleneimine (PEI), with the large amount amine groups, can reduce and simultaneously functionalize GO under alkaline conditions and mild temperatures [ 28 ]. The conductivity of reduced graphene oxide (rGO) is eight times higher than that of GO [ 29 ], and its carboxyl group can be covalently bonded to PEI with highly active primary amino sites. Synthesized rGO-PEI has a larger specific surface and a bigger space charge layer than a two-dimensional sheet of graphene, so it exhibits excellent electrochemical activity [ 30 ].…”