Utilization of the high spatial-frequency component in adaptive beam shaping by using a virtual diagonal phase grating

Nakata, Yoshiki; Osawa, Kazuhito; Miyanaga, Noriaki

doi:10.1038/s41598-019-40829-7

Cited by 18 publications

(13 citation statements)

References 27 publications

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“…[68][69][70] However, in the current study, a square gradient beam profile was chosen as appropriate for a dual laser in order to simplify the experimental procedures. We used a square-core fiber to create a square beam profile because the use of the fiber is easier and more affordable than the phase gating 71 or a micromirror device. 72 Such a system is useful to study the biological effect of NIR light.…”

Section: Discussionmentioning

confidence: 99%

High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells

et al. 2020

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Significance: Photobiomodulation is a well-established therapeutic modality. However, the mechanism of action is poorly understood, due to lack of research in the causal relationship between the near-infrared (NIR) light irradiation and its specific biological effects, hindering broader applications of this technology. Aim: Since biological chromophores typically show several absorption peaks, we determined whether specific effects of photobiomodulation are induced with a combination of two wavelengths at a certain range of irradiance only, rather than a single wavelength of NIR light. Approach: In order to analyze a wide array of combinations of multispectral NIR light at various irradiances efficiently, we developed a new optical platform equipped with two distinct wavelengths of NIR lasers by high-throughput multiple dosing for single-cell live imaging. Two wavelengths of 1064 and 1270 nm were selected based on their photobiomodulatory effects reported in the literature. Results: A specific combination of wavelengths at low irradiances (250 to 400 mW∕cm 2 for 1064 nm and 55 to 65 mW∕cm 2 for 1270 nm) modulates mitochondrial retrograde signaling, including intracellular calcium and reactive oxygen species in T cells. The time-dependent density functional theory computation of binding of nitric oxide (NO) to cytochrome c oxidase indicates that the illumination with NIR light could result in the NO release, which might be involved in these changes. Conclusions: This optical platform is a powerful tool to study causal relationship between a specific parameter of NIR light and its biological effects. Such a platform is useful for a further mechanistic study on not only photobiomodulation but also other modalities in photomedicine.

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Section: Discussionmentioning

confidence: 99%

High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells

et al. 2020

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“…Also, as discussed in the above, the pulse energy fluctuation and the spatial intensity non-uniformity of the laser beam have to be well controlled to reduce the nonlinear phase variation induced in the post-compression. In order to achieve a flattop signal beam in OPCPA and/or WNOPCPA, the beam smoothing technologies should be considered in the pump beam in the future 64 . www.nature.com/scientificreports/ There are other potential problems to realize a sub-optical-cycle EW-class laser.…”

Section: Discussionmentioning

confidence: 99%

Simulating an ultra-broadband concept for Exawatt-class lasers

Kato

Kawanaka

2021

Sci Rep

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The rapid development of the optical-cycle-level ultra-fast laser technologies may break through the bottleneck of the traditional ultra-intense laser [i.e., Petawatt (PW, 1015 W) laser currently] and enable the generation of even higher peak-power/intensity lasers. Herein, we simulate an ultra-broadband concept for the realization of an Exawatt-class (EW, 1018 W) high peak-power laser, where the wide-angle non-collinear optical parametric chirped-pulse amplification (WNOPCPA) is combined with the thin-plate post-compression. A frequency-chirped carrier-envelope-phase stable super-continuum laser is amplified to high-energy in WNOPCPA by pumping with two pump-beamlets and injected into the thin-plate post-compression to generate a sub-optical-cycle high-energy laser pulse. The numerical simulation shows this hybrid concept significantly enhances the gain bandwidth in the high-energy amplifier and the spectral broadening in the post-compression. By using this concept, a study of a prototype design of a 0.5 EW system is presented, and several key challenges are also examined.

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“…However, in this method, it was necessary to cut the high spatial-frequency (HSF) component from the extracted component due to the overlapping between the extracted and residual components in the Fourier plane, which limits the flatness and the edge steepness of the resultant beam shape. Recently, a novel beam shaping technique with high accuracy has been proposed by optimizing virtual phase grating (Nakata et al 2019). As illustrated in Fig.…”

Section: Parallel Ultrashort Pulse Laser Processing Systemsmentioning

confidence: 99%

mentioning

confidence: 99%

Basic Optics and Diagnostics Apparatus for Ultrashort Pulse Laser Micro-/Nanoprocessing

Xu¹,

Cheng²,

Sugioka³

2020

Handbook of Laser Micro- And Nano-Engineering

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With a significantly improved processing precision, quality, and flexibility in 3D space, ultrashort pulse laser processing at the micro-and nanoscales has exhibited superior performances in the fields of fundamental research and industrial manufacturing as compared with traditional long-pulse and continuous laser processing in the past decades. In this chapter, basic optics for ultrashort pulse laser micro-/nanoprocessing are introduced. Specifically, basic optical setups of two representative processing systems (3D ultrashort laser direct writing systems and laser parallel processing systems) are described as well as their crucial optical components. Recent advances of ultrashort laser micro-/nanoprocessing such as spatiotemporal beam shaping and homogenization of femtosecond laser pulses are presented. Moreover, typical diagnosis systems for ultrashort pulse laser processing such as basic optical setups for measurement of pulse durations and transient pump-probe imaging are briefly summarized.

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Utilization of the high spatial-frequency component in adaptive beam shaping by using a virtual diagonal phase grating

Cited by 18 publications

References 27 publications

High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells

High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells

Simulating an ultra-broadband concept for Exawatt-class lasers

Basic Optics and Diagnostics Apparatus for Ultrashort Pulse Laser Micro-/Nanoprocessing

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