UV curable polyester polyol acrylate/bentonite nanocomposites: Synthesis, characterization, and drug release

Abstract

Polyesterpolyolacrylate/bentonite nanocomposites, capable of in situ photo polymerization, were synthesized and characterized. The organically modified bentonite clay was prepared by an ion exchange process, in which sodium ions were replaced by alkyl ammonium ions. Organo modification of bentonite was confirmed from X-ray diffraction and fourier transform-infrared data. Microstructures were characterized by XRD data and transmission electron microscopy (TEM). Both XRD data and TEM images of polyester polyol acrylate/organo modified bentonite nanocomposites indicated that most of silicate layers were intercalated into the acrylate matrix. The resulting nanocomposites were characterized by gel content, water equilibrium swell, tensile strength, and in vitro degradation. The results showed that water equilibrium swell and in vitro degradation of these nanocomposites decreased with increase in the clay content. The tensile strength of these nanocomposites also increased with increase in the clay content. Release of two model drugs namely sulfamethoxazole and diclofenac sodium (DS) from these nanocomposites was studied in phosphate buffer saline pH = 7.4 at 37 degrees C. The drug release studies showed that sulfamethoxazole released slower than DS from polyester polyol acrylate nanocomposites. Therefore, these materials may be useful for mucoadhesive drug carriers and other biomedical applications.

Copolymer/Clay Nanocomposites for Biomedical Applications

“…There are other reports, which provided insight into the improvement of biodegradability, cell metabolic activity, release characteristics, microbial protection, equilibrium swelling, in vivo biocompatibility with minimal inflammation, and mechanical properties of various copolymer/nanoclay composite films. Examples are chlorhexidine acetate loaded PU/MMT films, [ 81b ] laponite/mafenide/alginate films, [ 90 ] sulfamethoxazole and diclofenac sodium embedded polyester polyol acrylate/bentonite nanocomposite films [ 91 ] and soy protein/MMT films for ofloxacin drug release. [ 92 ] The above‐mentioned findings suggested that the intercalated nanoclay morphology is capable of loading high amounts of drug and yielding a more prolonged release compared to that of the exfoliated structure.…”

Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems

“…Montmorillonite has been applied with acrylic acid and its derivatives to design a newly structured drug carrier system (Lee and Chen 2004;Thatiparti et al 2010;Bhattacharya et al 2011;Hosseinzadeh et al 2011). One interesting approach is to polymerize acrylic acid monomers in a montmorillonite suspension, rather than mixing poly(acrylic acid) with montmorillonite ( Fig.…”

“…They reported that gel strength of the prepared hydrogel increased and release of a cationic drug decreased. Moreover, similar to alginate film, incorporating montmorillonite increased tensile strength and decreased degradation and drug release rates of a polyester polyol acrylate-based film (Thatiparti et al 2010). Polyamide and polyacrylamide have also been studied as montmorillonite-mixed formulations (Kevadiya et al 2013;Salahuddin et al 2014).…”

“…This modified montmorillonite is well exfoliated by efficient crosslinking with other acrylate monomers, and the exfoliation contributes to increase montmorillonite surface area and enhance interactions with the gel matrix. In another study, dodecylamine was intercalated to increase hydrophobicity of the montmorillonite interlayer (Thatiparti et al 2010). Then, the hydrophobic monomer infiltrated well into this organo-modified clay, resulting in well-mixed composite (Table 1).…”

Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose‐g‐poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac

“…In order to resolve the above shortcomings of pure polymer or clays in drug delivery system, new strategies are reported that clays have been introduced into polymer by different methods 10–12. It was found that the introduction of versatile inorganic materials could not only remedy some flaws of the neat polymers but also often endow them with novel properties 13, 14.…”