UV-initiated crosslinking of electrospun chitosan/poly(ethylene oxide) nanofibers doped with ZnO-nanoparticles: development of antibacterial nanofibrous hydrogel

Estrada-Villegas, G. M.; Vicente, John; Argueta-Figueroa, Liliana; González-Pérez, Giovanni

doi:10.1557/mrc.2020.74

Cited by 10 publications

(8 citation statements)

References 31 publications

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“…Moreover, PEO is employed in combination with chitosan to form uniform nanofibers with suitable mechanical properties for wound healing and tissue engineering applications. 23 , 24 …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, PEO is employed in combination with chitosan to form uniform nanofibers with suitable mechanical properties for wound healing and tissue engineering applications. 23,24 Silver nanoparticles are the most prevalent nanostructures for antimicrobial therapy due to their potent microbicide properties. 25 Ag nanoparticles have been employed in numerous approaches for wound treatment, such as impregnation of silver nanoparticles in polymeric bandages for upgrading of the existing polymer-based moist wound dressings or adding of silver ions in hydrocolloids, foams (PolyMem Silver), hydrogel (SilvaSorb gel), alginate dressings and silver sulfadiazine (SSD) creams and gauze dressings (Urgotul ® SSD, Askina Calgitrol Ag [silver alginate], Acticoat™).…”

mentioning

confidence: 99%

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Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

Bagheri

Validi

Gholipour

et al. 2021

Bioengineering & Transla Med

165

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Bacterial wound infection is one of the most common nosocomial infections.The unnecessary employment of antibiotics led to raising the growth of antibioticresistant bacteria. Accordingly, alternative armaments capable of accelerating wound healing along with bactericidal effects are urgently needed. Considering this, we fabricated chitosan (CS)/polyethylene oxide (PEO) nanofibers armed with antibacterial silver and zinc oxide nanoparticles. The nanocomposites exhibited a high antioxidant effect and antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Besides, based on the results of the cell viability assays, the optimum concentration of ZnONPs and AgNPs in the nanofibrous mats is 0.2% w/v and 0.08% w/v respectively and had no cytotoxicity on fibroblast cells. The scaffold also showed good blood compatibility according to the effects of coagulation time. As well as significant fibroblast migration and proliferation on the wound margin, according to wound-healing assay. All in all, the developed biocompatible, antioxidant, and antibacterial Ag-ZnO NPs incorporated CS/PEO nanofibrous mats showed their potential as an effective wound dressing.antibacterial, antioxidant, chitosan/polyethylene oxide nanofibers, electrospun, silver nanoparticles, wound healing, zinc oxide nanoparticles | INTRODUCTIONWound infection is a common and unsolved issue in preventing wound healing. Any kind of wound on the skin is susceptible to the accumulation of infectious bacteria. 1 With the spread of antibiotic-resistant bacteria, employing antibiotics to prevent and treat wound infections is inefficient.In addition, it imposes extra costs on the patient and society. Consequently, alternative materials are pivotal to combat pathogens. 2,3

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“…Moreover, PEO is employed in combination with chitosan to form uniform nanofibers with suitable mechanical properties for wound healing and tissue engineering applications. 23 , 24 …”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

Bagheri

Validi

Gholipour

et al. 2021

Bioengineering & Transla Med

165

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“…Nanotechnology has been used as a novel approach to improve bioactive dental materials [ 41 , 42 ]. Micro-nano materials with regenerative dentin properties have also been developed for dental pulp capping [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy of Biomimetic Bioactive Biomaterials for Dental Pulp Capping: A Systematic Review and Meta-Analysis

et al. 2022

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Recently, biomimetic bioactive biomaterials have been introduced to the market for dental pulp capping. This systematic review and meta-analysis aimed to determine any variation between the effect of using TheraCal LC and other bioactive biomaterials for pulp capping is different, as measured by dentin increment and clinical success. The risk of bias was assessed using the Risk of Bias 2 and Newcastle–Ottawa tools for randomized clinical trials and observational studies. A search for relevant articles was performed on five databases. Additionally, the quality of the included studies was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. A summary of individual studies and a meta-analysis were performed. The odds ratio of data from clinical success was combined using a random-effects meta-analysis. The meta-analysis results showed homogeneity between the studies (I2 = 0%). They revealed that the clinical success showed no differences between the patients who received TheraCal LC, light-cured calcium silicate-based biomimetic biomaterial, for dental pulp capping or the comparator biomaterials (p > 0.5). However, the certainty of the evidence was low to moderate due to the risk of bias in the included studies.

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“…This increase in the amount of charges allowed for additional elongation and stretching of the solution jet during electrospinning, resulting in a reduction in the fiber diameter. 42 Electrospinning solutions that exceed critical and optimum parameter values result in the formation of beads and fibers with beads. The formation of these beads can be attributed to a reduction in the Taylor cone size and an increase in the jet velocity.…”

Section: Characterization Of Biosynthesized Ch-cuomentioning

confidence: 99%

Chitosan-Stabilized CuO Nanostructure-Functionalized UV-Crosslinked PVA/Chitosan Electrospun Membrane as Enhanced Wound Dressing

Khan,

Arafat,

Rashid

et al. 2024

ACS Appl. Bio Mater.

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Electrospun nanofibrous membranes are of great interest for tissue engineering, active material delivery, and wound dressing. These nanofibers possess unique three-dimensional (3D) interconnected porous structures that result in a higher surface-area-to-volume ratio and porosity. This study was carried out to prepare nanofibrous membranes by electrospinning a blend of PVA/chitosan polymeric solution functionalized with different ratios of copper oxide. Chitosan-stabilized CuO nanoparticles (CH-CuO NPs) were biosynthesized successfully utilizing chitosan as the capping and reducing agent. XRD analysis confirmed the monoclinic structure of CH-CuO NPs. In addition, the electrospun nanofibrous membranes were UV-crosslinked for a definite time. The membranes containing CH-CuO NPs were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, ultraviolet−visible (UV−vis) spectrophotometry, and dynamic light scattering (DLS). SEM results showed the nanosize of the fiber diameter in the range of 147−207 nm. The FTIR spectroscopy results indicated the successful incorporation of CH-CuO NPs into the PVA/chitosan nanofibrous membranes. DSC analysis proved the enhanced thermal stability of the nanofibrous membranes due to UV-crosslinking. Swelling and degradation tests were carried out to ensure membrane stability. Greater antimicrobial activity was observed in the nanoparticle-loaded membrane. An in vitro release study of Cu 2+ ions from the membrane was carried out for 24 h. The cytotoxicity of CH-CuO NP-incorporated membranes was investigated to estimate the safe dose of nanoparticles. An in vivo test using the CH-CuO NP-loaded PVA/chitosan membrane was conducted on a mice model, in which wound healing occurred in approximately 12 days. These results confirmed that the biocompatible, nontoxic nanofibrous membranes are ideal for wounddressing applications.

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UV-initiated crosslinking of electrospun chitosan/poly(ethylene oxide) nanofibers doped with ZnO-nanoparticles: development of antibacterial nanofibrous hydrogel

Cited by 10 publications

References 31 publications

Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect

Clinical Efficacy of Biomimetic Bioactive Biomaterials for Dental Pulp Capping: A Systematic Review and Meta-Analysis

Chitosan-Stabilized CuO Nanostructure-Functionalized UV-Crosslinked PVA/Chitosan Electrospun Membrane as Enhanced Wound Dressing

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