UV Irradiation and Blood Pressure — the Role of Vitamin D in Essential Hypertension

Krause, Rolfdieter; Bühring, M.; Sharma, Arya M.; Hopfenmüller, Werner; Chen, T. C.; Holick, Michael F.

doi:10.1007/978-1-4615-5051-8_42

Cited by 3 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A dose–response relationship is suggested with increasing serum 25(OH)D from the deficient range to the physiological range (>100 nmol/L) and associated with significant reductions in systolic (−7.5 mmHg), diastolic (−4.4 mmHg) and MAP (−5.3 mmHg). As discussed above, the results of the present study are consistent with others investigating benefit of vitamin D supplementation for hypertension [ 7 , 20 , 41 , 43 , 55 , 56 , 57 ] and provide support for the reasoning for discrepant results [ 46 ]. Specificity and temporality are suggested by observational data and the current study lends support, but definitive evidence is still lacking.…”

Section: Discussionsupporting

confidence: 92%

“…In addition to the present study, others have shown vitamin D supplementation provides a blood pressure lowering effect in specific subpopulations, including patients with hypertension, low serum vitamin D status or cardiometabolic diseases in other studies [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. A recent randomized controlled trial sub-study found lower blood pressure in vitamin D deficient individuals when treated with high-dose vitamin D supplementation long-term to maintain serum 25(OH)D above 100 nmol/L [ 43 ].…”

Section: Discussionsupporting

confidence: 58%

See 1 more Smart Citation

The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

2017

View full text Add to dashboard Cite

Background: Vitamin D deficiency is a risk factor for hypertension. Methods: We assessed 8155 participants in a community-based program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after program entry. Results: At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = −0.07, p < 0.001; diastolic BP: coefficient = −0.1, p < 0.001). Reduced mean systolic (−18 vs. −14 mmHg) and diastolic (−12 vs. −12 mmHg) BP, pulse pressure (−5 vs. −1 mmHg) and mean arterial pressure (−14 vs. −13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication. Conclusion: Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 58%

The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

2017

View full text Add to dashboard Cite

show abstract

“…The prevalence of vitamin D deficiency is directly related to higher latitudes due to less intense UVB radiation, colder climates due to less skin exposure, and darker skin as it interferes with UVB penetration and decreases vitamin D production [13]. The fact that a higher EH frequency is observed in winter in people living at higher latitudes and in people with deep skin pigmentation living far from the equator suggests that vitamin D deficiency may contribute to an increased prevalence of arterial [14] used ultraviolet radiation to treat patients with untreated mild arterial hypertension (AH) and vitamin D deficiency. These researchers found that UV radiation increased 25 (OH) D levels and lowered blood pressure in patients with vitamin D deficiency with AH.…”

Section: Role Of Vitamin D In Pathophysiology and Development Of Hype...mentioning

confidence: 99%

Mechanism of Development of Arterial Hypertension Associated with the Exchange of Level Vitamin D

Gahramanova¹

2022

Hypertension - An Update

View full text Add to dashboard Cite

Arterial hypertension (AH) is one of the most chronic and fatal disorders in the world, the main risk factors for which are age, hereditary predisposition, race, tobacco use, high salt intake, etc., as well as low vitamin D. In the last 10 years, there has been an increasing interest in the extraosseous effects of vitamin D. Being a hormone-like vitamin, it participates in many vital processes of the body. Its level is closely related to various metabolic disorders, diseases of the cardiovascular system (CVS), arterial hypertension (AH), diabetes mellitus, the immune system, cancer, etc. Vitamin D improves vascular endothelial function, due to which it has a vasoprotective effect, improves blood pressure, reduces vascular and myocardial remodeling, reduces the risk of left ventricular hypertrophy, slows down fibrosis, reduces the risk of atherosclerosis, reduces insulin resistance and inflammation, and improves immunity. It has been proven that vitamin D has an inverse relationship with renin, it reduces the expression of the renin gene. At a normal level of vitamin D, the concentration of renin and aldosterone II decreases, which has a positive effect on the course of hypertension.

show abstract

“…According to a recently published report, approximately 40.7% of adult people suffer from hypertension in Bangladesh [4]. To date, vitamin D deficiency is abundant in the Bangladeshi population, and preceding study has revealed that low vitamin D levels augment the risk of hypertension [5].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and the vitamin D receptor (VDR) gene polymorphism rs2228570 (FokI) are associated with an increased susceptibility to hypertension among the Bangladeshi population

Nabil,

Mahmud,

Tamanna

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Vitamin D receptor (VDR) gene is implicated in hypertension vulnerability due to its role in regulating the renin-angiotensin system (RAS) and blood pressure. In this case-control study, a carefully selected cohort of 111 hypertensive individuals and 100 healthy controls underwent serum analysis using HPLC to measure 25-hydroxy vitamin D levels. Polymorphic variations in the VDR gene were detected and characterized using the PCR-RFLP method. At first, lower 25-hydroxy vitamin D levels were observed in hypertensive individuals compared to controls (p<0.001). The genotype frequency of the VDR gene TaqI showed no significant difference between cases and controls (p>0.05). Similarly, no significant difference was found in the VDR gene BsmI genotype frequency between hypertensive patients and controls (p>0.05). However, a statistically significant distinction was observed in the VDR gene FokI genotype frequency between cases and controls (p<0.01). The odds ratios for FokI genotypes (CC, CT, TT, and CT+TT) were 1.0, 0.590, 1.566, and 0.963, respectively. Furthermore, serum 25-hydroxy vitamin D levels were significantly higher in control subjects compared to hypertensive patients across all genotypes of VDR (p<0.001). Hypertensive patients, excluding those with the FokI VDR gene CC genotype, exhibited significantly higher systolic blood pressure levels compared to the control group (p<0.05). Similarly, hypertensive subjects displayed elevated diastolic blood pressure levels compared to the control group (p<0.001). Overall, the results suggest the presence of a potential inverse correlation between serum 25-hydroxy vitamin D levels and hypertension. The association analysis conducted indicated that there is no significant association between TaqI and bsmI genotypic variants and the risk of developing hypertension. However, it was observed that VDR gene polymorphisms do have a clear association with hypertension susceptibility, as evidenced by the significantly higher occurrence of FokI genotypic variants in hypertensive patients. Our study therefore introduces the possibility of utilizing 25-hydroxy vitamin D deficiency and VDR gene polymorphisms as a biomarker for hypertension.

show abstract

UV Irradiation and Blood Pressure — the Role of Vitamin D in Essential Hypertension

Cited by 3 publications

References 26 publications

The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements

Mechanism of Development of Arterial Hypertension Associated with the Exchange of Level Vitamin D

Vitamin D deficiency and the vitamin D receptor (VDR) gene polymorphism rs2228570 (FokI) are associated with an increased susceptibility to hypertension among the Bangladeshi population

Contact Info

Product

Resources

About